GNE-7883 is a potent, allosteric TEAD inhibitor. It affects the Hippo/YAP/TAZ signaling pathway by binding to the TEAD lipid pocket to block YAP/TAZ interaction, effectively inhibiting cancer cell proliferation and colony formation.
GNE-7883 Mechanism of Action: TEAD Inhibition in Cancer Cell Research
GNE-7883 MOA：Targeting TEAD/Hippo Pathway for Targeted Therapy Resistance