GNE-7883 is a potent, allosteric TEAD inhibitor. It affects the Hippo/YAP/TAZ signaling pathway by binding to the TEAD lipid pocket to block YAP/TAZ interaction, effectively inhibiting cancer cell proliferation and colony formation.
GNE-7883 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for GNE-7883 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.