GNE-7883 IC50 for Cell-based and Cell-free Assays

Cell-free Assays (IC₅₀/K_i) for GNE-7883

Key Target	IC₅₀ (Cell-free)	Description	Reference
TEAD1	34 nM	Lipid HTRF assay	PM34685695
TEAD2	14 nM	Lipid HTRF assay	PM34685695
TEAD3	37 nM	Lipid HTRF assay	PM34685695
TEAD4	13 nM	Lipid HTRF assay	PM34685695
TEAD1 (YAP binding)	0.04 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD2 (YAP binding)	0.01 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD3 (YAP binding)	0.09 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD4 (YAP binding)	0.03 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD1 (TAZ binding)	0.05 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD2 (TAZ binding)	0.01 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD3 (TAZ binding)	0.10 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD4 (TAZ binding)	0.03 µM	TEAD–YAP/TAZ time-resolved fluorescence resonance energy transfer (TR-FRET) assay	PM37277530
TEAD lipid pocket	0.02 µM	Lipid displacement assay	PM37277530

Cell Type	IC₅₀ (Cell-based)	Description	Reference
No published data available.

Check the GNE-7883 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.