CAS No. 122111-03-9
| IUPAC Name | 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride | |
|---|---|---|
| CAS Number | 122111-03-9 | |
| Molecular Formula |
C9H11F2N3O4.HCI |
|
| Molecular Weight (MW) | 299.66 | |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl | |
| InChIKey | OKKDEIYWILRZIA-OSZBKLCCSA-N |
Gemcitabine hydrochloride is a pyrimidine nucleoside analog and antimetabolite that inhibits DNA synthesis. Upon intracellular conversion to active metabolites, difluorodeoxycytidine diphosphate inhibits ribonucleotide reductase to deplete intracellular deoxynucleotide pools, while difluorodeoxycytidine triphosphate incorporates into DNA. These actions block DNA replication and repair, downstream arresting the cell cycle and inducing autophagy and apoptosis in cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 59 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 59 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 60 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 30 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 19 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Gemcitabine Hydrochloride Mechanism of Action: Ribonucleotide Reductase Inhibition in Pancreatic Tumor Cell Research
- Gemcitabine Hydrochloride Clinical Trials
- Gemcitabine Hydrochloride: Selectivity & Specificity
- Gemcitabine Hydrochloride Working Concentration | Cell Culture | Treatment
- Gemcitabine Hydrochloride Solubility in DMSO
- Gemcitabine Hydrochloride Stock Solution
- Gemcitabine Hydrochloride Storage
- Gemcitabine Hydrochloride Stability
- Gemcitabine Hydrochloride Combination Database
- Gemcitabine Hydrochloride Molecular Weight
- Gemcitabine Hydrochloride SMILES
- Gemcitabine Hydrochloride Chemical Structure (2D and 3D)
- Gemcitabine Hydrochloride IC50 for Cell-based and Cell-free Assays
- Gemcitabine Hydrochloride Sigma (G6423)? Try a better option.
- Gemcitabine Hydrochloride MedChemExpress (HY-B0003)? Try a better option.
- Gemcitabine Hydrochloride Cayman (9003096)? Try a better option.
- Gemcitabine Hydrochloride APExBIO (A1402)? Try a better option.
- Gemcitabine Hydrochloride Tocris (3259)? Try a better option.
- Gemcitabine Hydrochloride SDS｜MSDS