CAS No. 184475-35-2
Batch:
Purity:99.97
Chemical Structure
Check the
Gefitinib (ZD1839)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | |
|---|---|---|
| CAS Number | 184475-35-2 | |
| Molecular Formula |
C22H24ClFN4O3 |
|
| Molecular Weight (MW) | 446.90 | |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 | |
| InChIKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
Biological Activity
Gefitinib (ZD1839) is a potent, orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with an IC50 of 0.033 μM. By selective inhibition of EGFR autophosphorylation, gefitinib disrupts downstream intracellular signaling cascades, including the PI3K/AKT/mTOR and MAPK pathways. This blockade effectively suppresses cell proliferation, promotes autophagy, and induces apoptosis in sensitive cancer cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
45 mg/mL
(100.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Gefitinib (ZD1839) Mechanism of Action: EGFR Inhibition in Non-Small Cell Lung Cancer Cells Research
- Gefitinib (ZD1839) Clinical Trials
- Gefitinib (ZD1839) Working Concentration | Cell Culture | Treatment
- Gefitinib (ZD1839) Solubility in DMSO
- Gefitinib (ZD1839) Stock Solution
- Gefitinib (ZD1839) Storage
- Gefitinib (ZD1839) Stability
- Gefitinib (ZD1839) Combination Database
- Gefitinib (ZD1839) Molecular Weight
- Gefitinib (ZD1839) SMILES
- Gefitinib (ZD1839) Chemical Structure (2D and 3D)
- Gefitinib (ZD1839) IC50 for Cell-based and Cell-free Assays
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- Gefitinib (ZD1839) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.