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Fasudil (HA-1077) Hydrochloride is a potent ROCK inhibitor. It affects RhoA/ROCK, MAPK, and AMPK signaling pathways. By inhibiting ROCK activity and reducing MLC and MYPT1 phosphorylation, it suppresses actin stress fiber formation, cell migration, apoptosis, and fibrosis, while promoting vasodilation and neuroprotection.