Fasudil (HA-1077) Hydrochloride is a potent ROCK inhibitor. It affects RhoA/ROCK, MAPK, and AMPK signaling pathways. By inhibiting ROCK activity and reducing MLC and MYPT1 phosphorylation, it suppresses actin stress fiber formation, cell migration, apoptosis, and fibrosis, while promoting vasodilation and neuroprotection.
Fasudil (HA-1077) Hydrochloride IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Fasudil (HA-1077) Hydrochloride Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.