Etoricoxib Clinical Trials

Size	Price	Qty
20mg	USD 147
100mg	USD 370

Clinical Trials

Numerous clinical trials evaluate etoricoxib across diverse therapeutic areas, focusing primarily on pain management and musculoskeletal conditions such as postoperative pain, osteoarthritis, headaches, and adjunct therapy for tuberculosis. Spanning Early Phase 1 through Phase 4, these studies are supported by academic institutions, university hospitals, and pharmaceutical sponsors. Although many trials investigating central nervous penetration and anti-inflammatory efficacy have reached completion, the broader clinical body includes active recruiting, terminated, withdrawn, and unknown recruitment statuses.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07370532	RECRUITING	Parkinson Disease	Ihab Elsayed Hassan	2026-01-30	PHASE2
NCT05683574	WITHDRAWN	Third Molar Extraction	Eurofarma Laboratorios S.A.	2026-05-30	PHASE3
NCT07661030	NOT_YET_RECRUITING	Gout	First Affiliated Hospital of Wenzhou Medical University	2026-07-30	PHASE4
NCT06863701	RECRUITING	Gout Arthritis; Gout Attack	Laboratorios Silanes S.A. de C.V.	2025-01-27	PHASE3
NCT06863662	COMPLETED	Acute Low-back Pain; Muscle Spasm; Back Pain	Laboratorios Silanes S.A. de C.V.	2024-09-18	PHASE3
NCT07328022	COMPLETED	Bursitis; Tendinitis; Synovitis	Laboratorios Silanes S.A. de C.V.	2025-05-14	PHASE3
NCT07559682	ACTIVE_NOT_RECRUITING	Orthodontic Pain (D013850)	Sharif Medical Research Center	2025-05-08	PHASE1
NCT07549386	COMPLETED	Pain Management; Osteoarthritis	Laboratorios Liomont	2024-05-24	PHASE3
NCT06401499	UNKNOWN	Back Pain Lower Back Chronic	Muhammad Ilyas	2024-06-01	PHASE4
NCT06517823	COMPLETED	Acute Low-back Pain	Laboratorios Silanes S.A. de C.V.	2024-04-26	PHASE3
NCT05256342	COMPLETED	Knee, Osteoarthritis (OA); Biomarkers for Prediction of OA Treatment Efficacy	Rambam Health Care Campus	2021-12-30
NCT06001112	COMPLETED	Acute Gout Arthritis; Acupuncture; Acute Pain	Guangdong Provincial Hospital of Traditional Chinese Medicine	2023-09-01
NCT04462666	UNKNOWN	Gouty Arthritis	Shanghai Yueyang Integrated Medicine Hospital	2020-07-01	PHASE2
NCT05791721	COMPLETED	Surgical Wound; Post Operative Pain	University of Belgrade	2021-10-11	PHASE4
NCT07454369	COMPLETED	Healthy	Laboratorios Silanes S.A. de C.V.	2022-10-24	PHASE1
NCT05995912	COMPLETED	Acute Pain; Postoperative Pain	Laboratorios Liomont	2021-09-29	PHASE2
NCT05142098	UNKNOWN	Effect of Drug	Dow University of Health Sciences	2022-01-01	EARLY_PHASE1
NCT04968158	COMPLETED	Acute Low Back Pain	Laboratorios Silanes S.A. de C.V.	2021-11-29	PHASE3
NCT05142098	Unknown status	Effect of Drug	Dow University of Health Sciences	2022-01-01	Early Phase 1
NCT05791721	Completed	Surgical Wound\|Post Operative Pain	University of Belgrade	2021-10-11	Phase 4
NCT04830579	UNKNOWN	Bioequivalence	Pharmtechnology LLC	2021-04-10	PHASE1
NCT04565600	COMPLETED	Pain Syndrome	Guangdong Provincial People's Hospital	2020-03-01	PHASE2
NCT05014490	COMPLETED	Bioequivalence; Healthy Subjects	Darnitsa Pharmaceutical Company	2021-02-24	PHASE1
NCT05532280	COMPLETED	Healthy Subjects	Future University in Egypt	2020-12-28	PHASE1
NCT05533073	COMPLETED	Healthy	Laboratorios Silanes S.A. de C.V.	2020-08-03	PHASE1
NCT02503839	COMPLETED	Tuberculosis	Anne Margarita Dyrhol Riise	2015-11	PHASE1
NCT03542955	COMPLETED	Cervical Osteoarthritis	BioElectronics Corporation	2018-05-01
NCT03011905	COMPLETED	Brachial Plexus Block; Pain, Postoperative	Oslo University Hospital	2017-01	PHASE3
NCT03697733	COMPLETED	Abnormal Uterine Bleeding	Department of Medical Services Ministry of Public Health of Thailand	2018-11-01
NCT02954484	COMPLETED	Pain, Postoperative	National University Hospital, Singapore	2015-04	PHASE3
NCT03582332	COMPLETED	Axial Spondyloarthritis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2016-01-02	PHASE4
NCT03422575	COMPLETED	Healthy	Dexa Medica Group	2015-12
NCT02503839	Completed	Tuberculosis	Anne Margarita Dyrhol Riise\|University of Oslo\|Statens Serum Institut\|Haukeland University Hospital\|Oslo University Hospital	2015-11	Phase 1
NCT00427999	COMPLETED	Prostate Cancer	Novartis Pharmaceuticals	2007-02	PHASE2
NCT02884986	COMPLETED	Adverse Anesthesia Outcome	Bnai Zion Medical Center	2015-01
NCT02750917	COMPLETED	Postoperative Pain	Foisor Orthopedics Clinical Hospital	2014-09	PHASE3
NCT02568735	COMPLETED	Pain, Postoperative	Kuopio University Hospital	2013-01	PHASE4
NCT01980940	COMPLETED	Osteoarthritis Pain	Organon and Co	2013-12-23	PHASE1; PHASE2
NCT01208207	COMPLETED	Spondylitis, Ankylosing	Organon and Co	2010-09-27	PHASE3
NCT01269515	COMPLETED	HIV	Dag Kvale	2010-10	PHASE2
NCT01229774	COMPLETED	Coxarthrosis; Arthroplasties Hip Replacement; Perioperative Blood Loss	University of Regensburg	2011-02	PHASE3
NCT02534610	COMPLETED	Postoperative Pain	Foisor Orthopedics Clinical Hospital	2014-01
NCT01208181	COMPLETED	Arthritis, Rheumatoid	Organon and Co	2010-09-27	PHASE3
NCT01614301	UNKNOWN	Advanced Melanoma	University of Regensburg	2012-05	PHASE1; PHASE2
NCT01979510	WITHDRAWN	Low Back Pain	Merck Sharp & Dohme LLC	2013-11	PHASE3
NCT01259830	TERMINATED	Post-operative Pain	Claudia Spies	2011-03	PHASE4
NCT01246362	COMPLETED	Knee Osteoarthritis	Singapore General Hospital	2011-07	PHASE2
NCT01619150	COMPLETED	Osteoarthritis	C4Pain	2012-07	PHASE2
NCT02149758	COMPLETED	Cyclooxygenase Two Inhibitors; Etoricoxib; Periodontitis; Superoxide Dismutase; Saliva	Tatyasaheb Kore Dental College	2013-01	PHASE4
NCT01091675	COMPLETED	Ankylosing Spondylitis	Spanish Foundation of Rheumatology	2010-09	PHASE3
NCT01554163	COMPLETED	Osteoarthritis of the Knee	Organon and Co	2012-03	PHASE3
NCT02568735	Completed	Pain Postoperative	Kuopio University Hospital	2013-01	Phase 4
NCT01088256	TERMINATED	Causalgia; Polyneuropathy; Postherpetic Neuralgia; Peripheral Nerve Injury; Radiculopathy	Ruhr University of Bochum	2011-02	PHASE2
NCT01429168	WITHDRAWN	Osteoarthritis	Organon and Co	2011-10	PHASE4
NCT01572675	Completed	Osteoarthritis	Organon and Co	2012-06	--
NCT01462370	COMPLETED	Dysmenorrhea	Organon and Co	2011-11	PHASE3
NCT01002690	COMPLETED	Asthma	Barbro Dahlen	2009-10
NCT00792376	COMPLETED	Achilles Tendinopathy	Argentine Tennis Association	2009-08	PHASE4
NCT00927004	COMPLETED	Osteoarthritis; Pain	Curtin University	2010-08	PHASE4
NCT00763685	TERMINATED	Pain	East Tallinn Central Hospital	2010-06	PHASE4
NCT01271348	COMPLETED	Muscle Pain	X-pert Med GmbH	2011-01	PHASE1
NCT01022190	COMPLETED	Ossification, Heterotopic	Radboud University Medical Center	2009-12	PHASE4
NCT01300780	COMPLETED	Color Changes During Tooth Formation	Eloisa Andrade de Paula	2010-04
NCT01264237	UNKNOWN	Postherpetic Neuralgia; Neuralgia	Analgesic Solutions	2011-03	PHASE4
NCT01304069	COMPLETED	Healthy	Turku University Hospital	2011-01	PHASE1
NCT01344720	UNKNOWN	Low Back Pain	Azienda Sanitaria Locale 4, Teramo	2011-05	PHASE4
NCT00820027	COMPLETED	Pain, Postoperative	Organon and Co	2008-12-15	PHASE3
NCT01190722	WITHDRAWN	Hallux Valgus; Postoperative Pain	Karolinska Institutet	2010-11-10	PHASE4
NCT00954785	WITHDRAWN	Sprain	University of Cape Town	2009-11	PHASE4
NCT00876317	TERMINATED	Soft Tissue Injuries of the Shoulder; Tenosynovitis and Bursitis Affecting the Shoulder	Clinica Virgen Milagrosa	2009-11	PHASE3
NCT01067430	WITHDRAWN	Rheumatoid Arthritis	Northumbria Healthcare NHS Foundation Trust	2010-04	PHASE4
NCT00755521	UNKNOWN	Fibromyalgia	Meir Medical Center	2008-09	PHASE4
NCT00935116	UNKNOWN	Acute Pain	Hospital Padre Hurtado	2009-07	PHASE4
NCT01148303	COMPLETED	Headache; Fasting; Fasting Headache; Ramadan Headache	Hartford Hospital	2010-07	PHASE4
NCT00788710	COMPLETED	Acute Pain Following a Total Abdominal Hysterectomy	Organon and Co	2008-10	PHASE3
NCT00554346	COMPLETED	Post-operational Pain	National Taiwan University Hospital	2008-05	PHASE4
NCT00855777	UNKNOWN	Dental Extraction	Universita di Verona	2009-04	PHASE4
NCT00793052	UNKNOWN	Trismus; Edema; Pain	Tel-Aviv Sourasky Medical Center	2008-11
NCT01361789	COMPLETED	Rupture of Anterior Cruciate Ligament	Asker & Baerum Hospital	2004-01	PHASE4
NCT00756873	UNKNOWN	Tonsillectomy	University of Regensburg	2008-10	PHASE3
NCT00970112	COMPLETED	Pain Control	Universidade Estadual de Ponta Grossa	2008-11	PHASE2; PHASE3
NCT00525993	UNKNOWN	Sprains and Strains; Contusions	Núcleo de Estudos em Esportes e Ortopedia, Brazil	2008-12	PHASE4
NCT00746720	TERMINATED	Pain; Osteoarthritis, Hip; Postoperative Pain	University of Erlangen-Nürnberg Medical School	2006-05	PHASE2
NCT00733421	COMPLETED	Postoperative Pain	Karolinska Institutet	2008-10	PHASE4
NCT01017380	COMPLETED	Anterior Cruciate Ligament Injury	Prince of Songkla University	2008-01	PHASE3
NCT00757627	COMPLETED	Pain	Organon and Co	2007-12	PHASE4
NCT00694369	COMPLETED	Postoperative Dental Pain	Organon and Co	2008-06	PHASE3
NCT00752921	UNKNOWN	Headache	Shaare Zedek Medical Center	2008-09	PHASE4
NCT00264147	COMPLETED	Rheumatoid Arthritis	Organon and Co	2006-01	PHASE2
NCT00440739	COMPLETED	Pain	Mahidol University	2005-09	PHASE4
NCT04144101	COMPLETED	Rheumatoid Arthritis	Chung Shan Medical University	2007-03-01	PHASE4
NCT00799149	COMPLETED	Knee Arthroscopy	Meir Medical Center	2006-06	PHASE4
NCT00250445	COMPLETED	Rheumatoid Arthritis,Osteoarthritis	Organon and Co	2003-01	PHASE3
NCT00380627	COMPLETED	Pain	Organon and Co	2005-09-01	PHASE4
NCT00092742	COMPLETED	Rheumatoid Arthritis	Organon and Co	2003-02	PHASE3
NCT00140972	COMPLETED	Osteoarthritis	Organon and Co	2004-12-03	PHASE4
NCT00142558	COMPLETED	Acute Gout	Organon and Co	2005-01-01	PHASE4
NCT00380523	COMPLETED	Pain	Organon and Co	2005-04	PHASE4
NCT00090181	COMPLETED	Chronic Low Back Pain	Organon and Co	2004-06	PHASE4
NCT00092781	COMPLETED	Osteoarthritis	Organon and Co	2004-03-01	PHASE3
NCT00092768	COMPLETED	Osteoarthritis	Organon and Co	2004-03-01	PHASE3
NCT00092755	COMPLETED	Osteoarthritis	Organon and Co	2003-04-09	PHASE3
NCT00269191	COMPLETED	Osteoarthritis	Organon and Co	2003-02-05	PHASE3
NCT00092703	COMPLETED	Osteoarthritis	Organon and Co	2002-06-27	PHASE3
NCT00542087	COMPLETED	Osteoarthritis	Organon and Co	2002-03-22	PHASE3
NCT00092729	COMPLETED	Dysmenorrhea	Organon and Co	2002-06-07	PHASE3
NCT00945035	COMPLETED	Pain	Organon and Co	2002-11	PHASE1
NCT00393211	COMPLETED	Recurrent Low Back Pain	Organon and Co	2000-04	PHASE3
NCT00393354	COMPLETED	Recurrent Low Back Pain	Organon and Co	2000-04	PHASE3
NCT00242489	COMPLETED	Osteoarthritis	Organon and Co	1998-06	PHASE2
NCT00565682	COMPLETED	Laparoscopic Surgery for Appendicitis; Laparoscopic Surgery for Cholecystitis; Laparoscopic Surgery for Ovarian Cysts	Hospital Vozandez	2006-04	PHASE4
NCT00149253	COMPLETED	a Single-Dose of Etoricoxib; Post-Operative Morphine Consumption; Total Pain Relief Over 8 Hr(TOPAR8); Post Transabdominal Hysterectomy	Khon Kaen University	2004-12	PHASE3
NCT00095017	WITHDRAWN	Bone Neoplasms	Organon and Co	2004-11	PHASE2
NCT00529594	COMPLETED	Proliferative Diabetic Retinopathy	University of Sao Paulo	2006-08
NCT00373464	COMPLETED	Hysterectomy; Tubal Excision; Ovariectomy; Postoperative Pain	Ullevaal University Hospital	2006-03	PHASE3

(data from https://clinicaltrials.gov, updated on 2026-04-08)

Check the Etoricoxib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Etoricoxib selectively binds to and inhibits cyclooxygenase-2 (COX-2), thereby blocking the enzymatic conversion of arachidonic acid into pro-inflammatory prostaglandins such as PGE2. This selective blockade suppresses downstream inflammatory cascades, reduces vascular permeability, and diminishes peripheral nociceptive sensitization, providing clinically relevant pain relief and anti-inflammatory activity in conditions such as osteoarthritis and postoperative surgical pain.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).