CAS No. 202409-33-4
Batch:
Purity:99.61
Chemical Structure
Check the
Etoricoxib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-chloro-2-(6-methyl-3-pyridinyl)-3-(4-methylsulfonylphenyl)pyridine | |
|---|---|---|
| CAS Number | 202409-33-4 | |
| Molecular Formula |
C18H15ClN2O2S |
|
| Molecular Weight (MW) | 358.84 | |
| SMILES | CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C | |
| InChIKey | MNJVRJDLRVPLFE-UHFFFAOYSA-N |
Etoricoxib is a potent and highly selective inhibitor of cyclooxygenase-2 (COX-2). By inhibiting COX-2, it suppresses the conversion of arachidonic acid into pro-inflammatory prostaglandins, leading to reduced inflammatory responses, pain, and fever. In addition to its anti-inflammatory, analgesic, and antipyretic actions, COX-2 inhibition by etoricoxib modulates downstream cellular pathways to exert potential antineoplastic activities in preclinical cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(197.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 46 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.