BI-10773 (Empagliflozin): Selectivity & Specificity
BI-10773 (Empagliflozin) is a potent inhibitor of SGLT1 (8300 nM), SGLT2 (3.1 nM), hSGLT2 (3.1 nM), mSGLT2 (1.9 nM), and SMIT-1 (8.3 mM). BI-10773 (Empagliflozin) exhibits the greatest inhibitory potency toward mSGLT2 (IC50 = 1.9 nM).