Cell-free Assays (IC50/Ki) for BI-10773 (Empagliflozin)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| SGLT1 | 8300 nM | Half maximal inhibitory concentration (IC50) measurement | Download PDF |
| SGLT2 | 3.1 nM | Half maximal inhibitory concentration (IC50) measurement | Download PDF |
| hSGLT2 | 3.1 nM | SGLT2 inhibition assay | PMC7554656 |
| mSGLT2 | 1.9 nM | SGLT2 inhibition assay | PMC7554656 |
| SMIT-1 | 8.3 mM | Estimated | Download PDF |
Cell-based Assay (IC50) for BI-10773 (Empagliflozin)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| Human cardiomyocytes | 76.14 nM | ELISA assays for CXCL10 release, followed by dose-response curve analysis. | Download PDF |
| Recombinant human Nav1.5 α-subunit (expressed in HEK293T cells) | 0.79 µmol/L | Whole-cell patch-clamp recordings of peak- and late-INa, H2O2-induced late-INa. | Download PDF |
| SGLT2 | 3.1 nM | SGLT inhibition assay (cited from Grempler et al., 2012) | Download PDF |
| SGLT1 | 8,300 nM | SGLT inhibition assay (cited from Grempler et al., 2012) | Download PDF |
Check the
BI-10773 (Empagliflozin)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- BI-10773 (Empagliflozin) Mechanism of Action: SGLT2 Inhibition in Cardiomyocytes Research
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