Clinical Trials

Numerous clinical trials evaluate conditions ranging from neurological disorders such as amyotrophic lateral sclerosis, stroke, and spinal cord injury to oncology indications including breast cancer and pelvic bone metastasis. Spanning Phase 1 through Phase 4 interventions alongside procedural and non-applicable study designs, these trials are supported by governmental, academic, and corporate sponsors, including the VA Office of Research and Development, Assiut University, and Synchron, Inc. Recruitment statuses across the dataset vary, encompassing completed, actively recruiting, terminated, withdrawn, and not yet recruiting trials.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02550522 RECRUITING
Traumatic Tetraplegia with Cervical Cord Injury
University Hospital, Grenoble
 2015-09
NCT07698496 NOT_YET_RECRUITING
Locked in Syndrome; ALS (Amyotrophic Lateral Sclerosis)
University Hospital, Grenoble
 2026-10-10
NCT07225582 RECRUITING
Spinal Cord Injury Cervical; Spinal Cord Injuries (Complete and Incomplete)
Case Western Reserve University
 2026-01-13
NCT03898804 RECRUITING
Tetraplegia
University Hospitals Cleveland Medical Center
 2019-04-09
NCT07477613 RECRUITING
Stroke
University Hospital, Grenoble
 2026-04-08
NCT07457645 NOT_YET_RECRUITING
Tetraplegic Motor Dysfunction Following Brainstem or Spinal Cord Injury
Shanghai Zhongshan Hospital
 2026-05-15
NCT06818877 RECRUITING
Healthy Children; CP (Cerebral Palsy); CP; Cerebral Palsy
University of Nebraska
 2025-07-30
NCT06212219 RECRUITING
Cerebrovascular Accident
University Hospital, Toulouse
 2024-01-08
NCT06930313 NOT_YET_RECRUITING
Compassion
Taipei Medical University
 2026-03-01
NCT07327710 ENROLLING_BY_INVITATION
Peripheral Facial Palsy; Pulsed Radiofrequency; Brain-Computer Interface; Transcranial Direct Current Stimulation
Nanjing Medical University
 2025-11-30
NCT07269353 RECRUITING
Hemiparetic Cerebral Palsy
University of Alberta
 2026-02-05
NCT04421365 RECRUITING
Laryngeal Dystonia
Kristina Simonyan
 2022-04-18
NCT07073378 RECRUITING
Cerebral Palsy; Pediatric Stroke; Genetic Condition; Acquired Brain Injury (Including Stroke)
University of Calgary
 2025-11-01
NCT06417437 RECRUITING
Depression; Major Depressive Disorder; Bipolar Depression
Shanghai Mental Health Center
 2023-07-01 PHASE4
NCT07543185 NOT_YET_RECRUITING
Chronic Coronary Syndrome; Anxiety Disorder; High Ischemic Risk
Shenyang Medical College
 2026-04-19
NCT02098265 RECRUITING
Stroke
University of Wisconsin, Madison
 2010-06
NCT07784088 RECRUITING
Spinal Cord Injury Cervical; Tetraplegia/Tetraparesis; Spinal Cord Injuries (SCI)
BCIFlex Medical Technology Co., Ltd.
 2026-07-15
NCT07357428 RECRUITING
Amyotrophic Lateral Sclerosis; Neuromuscular Disease; Stroke; Tetraplegia/Tetraparesis; Cervical Spinal Cord Injury; Dysarthria
Paradromics
 2026-03-31
NCT07585058 NOT_YET_RECRUITING
Acute Ischemic Stroke
Shandong Provincial Hospital
 2026-04
NCT07374276 RECRUITING
Stroke
Technical University of Lisbon
 2026-01-05
NCT07533903 RECRUITING
Neurologic Disorder; Neurologic Diseases; MND (Motor Neurone DIsease); Motor Neuron Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Paralysis Arm; Paralysis
Synchron, Inc.
 2026-05-22
NCT06538506 NOT_YET_RECRUITING
Chronic Stroke
University of Calgary
 2024-08 PHASE2
NCT07720882 RECRUITING
Spinal Cord Injury
NeuroXess Technology (shanghai) Co.,Ltd.
 2026-07-07
NCT06406855 RECRUITING
Spinal Cord Injuries
University of Miami
 2024-05-07
NCT07446114 RECRUITING
Neurologic Disorder; ALS; Motor Neuron Disease
Synchron, Inc.
 2026-03-18
NCT07325370 RECRUITING
Recurrent Pregnancy Loss; Anxiety
Shenyang Medical College
 2025-12-29
NCT07081308 RECRUITING
Stroke
Research Center of Neurology, Russia
 2024-10-05
NCT03827187 RECRUITING
Disorder of Consciousness; Paralysis; Motor Neuron Disease; Stroke; Physical Disability
University of Ulster
 2022-02-08
NCT06940635 RECRUITING
Ischaemic Stroke; Hemorrhagic Stroke
VASCage GmbH
 2025-06-04
NCT06939660 RECRUITING
Spinal Cord Injuries (SCI); Spinal Cord Injury, Chronic; Spinal Cord Injury; Spinal Cord Injury Cervical; Spinal Cord Injury Thoracic; Spinal Cord Injury (Quadraplegia); Motor Impairment; Motor Deficits; Gait Training; Gait Impairment
Xuanwu Hospital, Beijing
 2025-04-23
NCT06521736 COMPLETED
Non-Verbal Communication; Degenerative Neurologic Disease
Kendrea Garand
 2024-09-13
NCT06940089 WITHDRAWN
Epilepsy in Children; Epilepsy
University of Texas at Austin
 2025-05-01
NCT06076928 RECRUITING
Stroke
Tan Tock Seng Hospital
 2024-08-01
NCT07760116 COMPLETED
Stroke; Hemiparesis; Gait Disorders, Neurologic
Taichung Veterans General Hospital
 2025-01-01
NCT06990412 COMPLETED
Tetraplegia; Spinal Cord Injuries (SCI)
Neuracle Medical Technology(Shanghai) Co.,Ltd.
 2025-05-28
NCT05965713 COMPLETED
Stroke; Hemiparesis; Spasticity as Sequela of Stroke; Brain Computer Interface; Chronic Stroke Survivors With Plegic Hand
Neurolutions, Inc.
 2023-10-01
NCT06810219 RECRUITING
ALS (Amyotrophic Lateral Sclerosis)
Cognixion
 2025-01-20
NCT05152108 ACTIVE_NOT_RECRUITING
Stroke
University of Belgrade
 2022-04-01
NCT04847089 COMPLETED
Stroke; Hemiparesis
Mälardalen University
 2022-04-14
NCT06753006 RECRUITING
Stroke; Stroke Acute; Stroke with Hemiparesis; Stroke, Acute; Stroke, Acute, Ischemic; Stroke, Ischemic
Neurotechnika
 2024-08-27
NCT05637775 COMPLETED
Spinal Cord Injuries; Motor Disorders
I.R.C.C.S. Fondazione Santa Lucia
 2022-11-15
NCT04468919 COMPLETED
Amyotrophic Lateral Sclerosis; Brainstem Stroke; Muscular Dystrophies; Parkinson's Disease and Parkinsonism; Multiple System Atrophy; Brain Tumor Adult; Spinal Cord Injuries; Locked-in Syndrome
Oregon Health and Science University
 2022-07-15
NCT07133347 COMPLETED
Perinatal Stroke; Hemiparetic Cerebral Palsy
University of Calgary
 2024-11-25 PHASE1
NCT04141774 COMPLETED
Stroke
University of Wisconsin, Madison
 2018-09-27
NCT05511207 COMPLETED
Stroke Sequelae; Motor Disorders
Donatella Mattia
 2023-03-01
NCT04279067 COMPLETED
Ischemic Stroke; Hemorrhagic Stroke
University of California, Irvine
 2020-05-15
NCT05470478 Not yet recruiting
Spinal Cord Injury|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked-in Syndrome|Muscular Dystrophy
VA Office of Research and Development
 2024-09-01 Not Applicable
NCT06513988 COMPLETED
Anterior Cruciate Ligament Injuries
Air Force Military Medical University, China
 2024-05-06
NCT05951556 UNKNOWN
Amyotrophic Lateral Sclerosis; Stroke
Shirley Ryan AbilityLab
 2021-09-30
NCT05908253 COMPLETED
Neurofeedback
University of Rhode Island
 2023-12-16
NCT03379532 COMPLETED
Stroke
University Hospital, Geneva
 2018-01-26
NCT06231628 Not yet recruiting
Imaging Guided|Percutaneous Cementoplasty|Pelvic Bone Metstasis
Assiut University
 2024-02 Not Applicable
NCT04376138 COMPLETED
Stroke
Universidade da Madeira
 2019-08-17
NCT04353297 COMPLETED
Stroke; Motor Disorders
I.R.C.C.S. Fondazione Santa Lucia
 2021-01-28
NCT05642299 UNKNOWN
Stroke
Tan Tock Seng Hospital
 2022-12-01
NCT05778448 COMPLETED
Stroke; Brain Computer Interface
The Hong Kong Polytechnic University
 2021-08-11
NCT05634616 UNKNOWN
Stroke; Neurorehabilitation; Motor Imagery; Motor Execution; Brain-computer Interface
First Affiliated Hospital Xi'an Jiaotong University
 2022-11-24
NCT04815486 COMPLETED
Stroke
Universidad Francisco de Vitoria
 2021-05-01
NCT03318549 COMPLETED
Glaucoma; Macular Degeneration; Glaucoma Suspect; Optic Neuropathy; Retinal Degeneration; Visual Pathway Disorder
University of Miami
 2018-10-29
NCT05215522 COMPLETED
Stroke
University of Sheffield
 2022-06-15
NCT03900247 UNKNOWN
Amyotrophic Lateral Sclerosis
University of Aarhus
 2019-03-18
NCT04704427 UNKNOWN
Stroke, Acute
Xuanwu Hospital, Beijing
 2021-01-16
NCT04651478 UNKNOWN
Parkinson Disease; Pain
Universidad Francisco de Vitoria
 2021-05-03
NCT04995367 COMPLETED
Stroke
Corporación de Rehabilitación Club de Leones Cruz del Sur
 2021-03-15
NCT03889353 COMPLETED
Neuropathic Pain
Nantes University Hospital
 2019-05-09
NCT05455073 COMPLETED
Anemia; Menstrual Hygiene Management; Improved Water, Sanitation and Hygiene (WASH)
Nutrition International
 2019-07-31
NCT02574026 COMPLETED
Functional Brain Mapping
University Hospital, Grenoble
 2010-08 PHASE1
NCT03611855 TERMINATED
Chronic Stroke; Hemiparesis
Washington University School of Medicine
 2018-04-26
NCT04188132 UNKNOWN
Stroke Sequelae; Brain Ischemia
University of Houston
 2019-11-05
NCT03289793 COMPLETED
Attention Deficit Disorder With Hyperactivity
Hospices Civils de Lyon
 2017-02-02
NCT03277508 COMPLETED
Stroke
National University Hospital, Singapore
 2018-03-02
NCT03032497 COMPLETED
Pain, Chronic
Tan Tock Seng Hospital
 2017-06-05
NCT03257982 COMPLETED
Spinal Cord Injuries
NHS Greater Glasgow and Clyde
 2018-01-25
NCT01852279 COMPLETED
Spinal Cord Injury
NHS Greater Glasgow and Clyde
 2013-05-08
NCT04439591 COMPLETED
Cognition
Geriatric Education and Research Institute
 2017-08-01
NCT03696667 COMPLETED
Emotion Regulation
Institute of Mental Health, Singapore
 2018-03-08
NCT01880268 UNKNOWN
Cerebrovascular Accident
China Medical University Hospital
 2013-07
NCT03098927 WITHDRAWN
Spinal Cord Injuries
The Cleveland Clinic
 2014-09-01
NCT02445625 COMPLETED
Autism Spectrum Disorder
University of Coimbra
 2016-02
NCT02507895 COMPLETED
Stroke
National University Hospital, Singapore
 2013-10
NCT02440451 COMPLETED
Autism Spectrum Disorder
University of Coimbra
 2016-02
NCT02325947 COMPLETED
Poststroke/CVA Paresis
Russian Academy of Medical Sciences
 2015-01
NCT02791425 TERMINATED
Mechanical Ventilation; Nonverbal Communication; Intratracheal Intubation; Critical Illness
University of Michigan
 2017-03-01
NCT02323061 COMPLETED
Stroke
Chinese University of Hong Kong
 2015-05-01
NCT02132520 COMPLETED
Hemiparesis; Stroke
University of Minnesota
 2014-03
NCT03488095 COMPLETED
Oral Cavity Carcinoma
Dow University of Health Sciences
 2016-05-01
NCT00746525 COMPLETED
Stroke
Louis Stokes VA Medical Center
 2008-09
NCT01344044 COMPLETED
Attention Deficit Hyperactivity Disorder
National Healthcare Group, Singapore
 2011-01 PHASE2; PHASE3
NCT02404857 COMPLETED
Poststroke/CVA Hemiparesis; Paralytic Stroke; Hand Flaccid Paralysis
University Hospital, Montpellier
 2015-01
NCT02057029 COMPLETED
Breast Cancer; Early Stage Estrogen Receptor (ER) Positive Breast Cancer
Yale University
 2014-01
NCT02374554 UNKNOWN
Pulmonary Disease
Pneumacare Ltd
 2015-02
NCT01897025 COMPLETED
Stroke
National University Hospital, Singapore
 2011-01 PHASE2
NCT01287975 COMPLETED
Stroke
Tan Tock Seng Hospital
 2011-01
NCT01548703 COMPLETED
Healthy
BrainCells Inc.
 2012-02 PHASE1
NCT00675961 COMPLETED
Tuberculosis; Alcohol Use Disorders
Brigham and Women's Hospital
 2007-01
NCT01123148 COMPLETED
Healthy; Amyotrophic Lateral Sclerosis
University of Michigan
 2010-01
NCT00955838 UNKNOWN
Stroke
National Neuroscience Institute
 2007-04
NCT00006034 COMPLETED
Bladder Cancer
Intracel
 1998-06 PHASE3

(data from https://clinicaltrials.gov, updated on 2024-12-16)

Check the (E/Z)-BCI product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

(E/Z)-BCI selectively inhibits dual specificity phosphatases 1 and 6 (DUSP1/DUSP6), thereby altering downstream mitogen-activated protein kinase signaling to stimulate reactive oxygen species generation and activate the intrinsic mitochondrial apoptotic pathway. This induction of apoptosis suppresses cell viability, offering mechanistic relevance to oncology conditions such as breast cancer and carcinoma evaluated in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.