Tetraethylthiuram disulfide (Disulfiram): Selectivity & Specificity

Tetraethylthiuram disulfide (Disulfiram) is a potent inhibitor of rainbow trout liver S9 fractions (CYP1A-like EROD) (Nominal: 32 ± 8 µM; Unbound: 29 ± 15 µM), rainbow trout liver S9 fractions (CYP3A-like BFCOD) (Nominal: 76 ± 15 µM; Unbound: 69 ± 35 µM), recombinant human ALDH2 protein (1.80 µM), gCK (0.58 µM), SVMP (Echis carinatus venom) (6 µM), Giardia lamblia triosephosphate isomerase C202A mutant (6.6 μM), ALDH1 enzyme (0.15 uM), ALDH2 enzyme (1.45 uM), ALDH1 (about 0.1 μg/mL), MAPK/ERK pathway (62.88 ± 0.01 nmol/L), PI3K/AKT pathway (62.88 ± 0.01 nmol/L), ALDH, DBH, NF-κB, Mitochondrial function, DNA repair pathway, NF-κB (p65), Angiogenesis, MMP, Glutathione, ROS, IL-18, VEGF, TNF, IL-8, MMP-2, MMP-9, Proteasome, SOD, P-glycoprotein, MGMT, DNA methyltransferase, NF-kB, DNA replication, Oxidative stress, Mitochondrial membrane permeabilization, Cancer stem cells, Superoxide dismutase, ICE-1, ALDH1A1, ROS reducing agents, Drug efflux pumps, Cancer stem cell function, Caspase-1, IL-1beta, FDX1, SLC31A1, ATP7B, SDHB, PD-L1, HIF-1A, DLAT, Fe-S cluster proteins, NPL4, MDA, Ubiquitin-proteasome system, Drug resistance, Stemness, Metastasis, Glyceraldehyde-3-phosphate dehydrogenase, Fructose-1,6-diphosphate dehydrogenase, Succinic dehydrogenase, Dopamine-β-hydroxylase, DNA repair pathways, MAPK pathway, ClC-3, 26S proteasome, p97 segregase, ATR kinase, NPL4/p97 complex, RPA-ATRIP-ATR-CHK1 repair pathway, STAT3 signalling pathway, P-gp, Nanog, Oct4, NF-kB signalling, PDL-1, SOD1, GSR, Mitochondrial membrane polarization, Extrinsic apoptosis pathway, GSDMD, POH1, Transcription factors, ATF/CREB, DNA topoisomerases, Type IV collagenase, Proteasome activity, Cell cycle, Tumor metastasis, Immune microenvironment, Cuproplasia, Ubiquitin proteasome activity, NF-kB signaling, Cu2+, ·OH, Copper transport, GPX4, NRF2, ALDH isozymes, JNK, p97 pathway, p97-NPL4-dependent processes, ER stress, HSR, DNA damage, GSCs, CSC, NF-kB-stemness gene pathway, Apoptosis, Autophagy, Cell cycle arrest, ICD, Stem cell properties, CSCs, Hypoxic cells, Stem cell transcription factors, ATP7A, NF-kB pathway, TCR signaling, Bivalent metal ion chelation, Caspase-8, ATOX1, JNK/JUN signaling, CD8+T cells, Gasdermin D, NET formation, NETs, Edema, Innate immune function, IL-1 signaling, PRR signaling, TLR signaling, Cytokine signaling, Viral life cycle, IFN signaling genes, IFN regulatory factors, SARS-CoV-2 infection pathway, Complement cascades, Coagulation cascades, Vasopressin-regulated pathways, Oxytocin pathways, Neutrophil infiltration, Heavily infiltrated lung area, Total number of cells, and Perivascular fibrosis. Tetraethylthiuram disulfide (Disulfiram) exhibits the greatest inhibitory potency toward MAPK/ERK pathway and PI3K/AKT pathway (IC50 = 62.88 nM).