Tetraethylthiuram disulfide (Disulfiram) SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Tetraethylthiuram disulfide (Disulfiram)
CAS Number: 97-77-8
PubChem CID: 3117
Molecular formula: C10H20N2S4
Molecular weight: 296.5 g/mol
IUPAC name: diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to t
Skin contact: Rinse skin with plenty of water or shower.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Use water spray, powder, foam, carbon dioxide.
Powder, water spray, foam, carbon dioxide.
Finely dispersed particles form explosive mixtures in air.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles.)
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
For more Preventive Measures (Complete) data for DISULFIRAM (8 total), please visit the HSDB record page.

7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material from exposure to light. Keep it away from oxidizing materials and store it under ambient temperatures. (NTP, 1992)
Separated from strong oxidants.
Commercially available disulfiram tablets should be protected from light and stored in tight, light-resistant containers at a temperature less than 40 °C preferably between 15-30 °C. Oral suspensions of disulfiram have been prepared extemporaneously from commercially available tablets of the drug. A suspension of 1% disulfiram, 1/4% methylcellulose, and 10% Tang /breakfast drink/ in distilled water has been reported to be stable for up to 6 months if refrigerated at 2-8 °C and protected from light.
Separated from strong oxidants.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants.
Commercially available disulfiram tablets should be protected from light and stored in tight, light-resistant containers at a temperature less than 40 °C preferably between 15-30 °C. Oral suspensions of disulfiram have been prepared extemporaneously from commercially available tablets of the drug. A suspension of 1% disulfiram, 1/4% methylcellulose, and 10% Tang /breakfast drink/ in distilled water has been reported to be stable for up to 6 months if refrigerated at 2-8 °C and protected from light.
Separated from strong oxidants.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Tetraethylthiuram disulfide appears as odorless or almost odorless white or almost white to tan powder. Unpleasant taste with metallic or garlic aftertaste. pH of a solution obtained by shaking 1 g with 30 mL of water is 6 to 8. (NTP, 1992)
b) Odor: Slight odor.
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 158 °F (NTP, 1992)
f) Initial boiling point and boiling range: 243 °F at 17 mmHg (NTP, 1992)
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0 mmHg at 68 °F approximately (NTP, 1992)
l) Vapor density: No data available
m) Relative density: 1.27 at 68 °F (NTP, 1992) - Denser than water; will sink
n) Water solubility: less than 0.1 mg/mL at 70 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 3.9
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 121 Ų
Complexity: 201

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
Suspected of causing genetic defects (H341).
Carcinogenicity:
No data available.
Reproductive toxicity:
Suspected of damaging fertility or the unborn child (H361).
Specific target organ toxicity (single exposure):
H370, H372, H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
Disulfiram
Group 3: Not classifiable as to its carcinogenicity to humans
Volume 12: (1976) Some Carbamates, Thiocarbamates and Carbazides
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
1987
1987
Tetraethylthiuram disulfide
TR-166: Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CASRN 97-77-8) (1979 )
12/13/78
No Evidence
No Evidence
No Evidence
No Evidence
It is conclu
Exposure routes:
The substance can be absorbed into the body by inhalation of dust and by ingestion.
inhalation, ingestion, skin and/or eye contact
Inhalation (MSDS, A308); ingestion (MSDS, A308); dermal (MSDS, A308) ; eye contact (MSDS, A308)
Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).
Signs and symptoms of exposure:
Confusion. Headache. Nausea. Vomiting.
irritation eyes, skin, respiratory system; sensitization dermatitis; lassitude (weakness, exhaustion), tremor, restlessness, headache, dizziness; metallic taste; peripheral neuropathy; liver damage
Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LC50 Poecilia reticulata (Guppy) 0.32 mg/L/96 hr /Conditions of bioassay not specified in source examined/
LC50 Daphnia magna 0.12 mg/L/48 hr /Conditions of bioassay not specified in source examined/
LC50 Oncorhynchus mykiss (Rainbow trout, donaldson trout; early life stage (fertilized egg to fry)) 9.0 ug/L/60 days (95% confidence interval: 8.0-10.0 ug/L); renewal /formulated product/
LC50 Brachydanio rerio (Zebrafish) early life stage 2.2 mg/L/7 days (95% confidence interval: 1.0-4.7 mg/L); renewal /formulated product/
EC50 Brachydanio rerio (Zebrafish) early life stage; (embryolethality and malformations) 0.13 mg/L/7 days (95% confidence interval: 0.10 -0.18 mg/L); renewal /formulated product/
The substance is toxic to aquatic organisms.
Disulfiram's production and use as a rubber accelerator and vulcanizer may result in its release to the environment through various waste streams; its use as a seed disinfectant and a fungicide will result in its direct release to the environment. In addition, disulfiram is administered as a pharmaceutical agent for the treatment of alcoholism. If released to air, an estimated vapor pressure of 8.7X10-4 mm Hg at 25 °C indicates disulfiram will exist solely as a vapor in the ambient atmosphere. Vapor-phase disulfiram will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 0.04 days. Disulfiram has a low absorption of light >290 nm, therefore, ph

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): 3.9
Potential for bioaccumulation exists (Log P > 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-
- TSCA Requirements: Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.
Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting
- FDA Requirements: The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl disulfiram, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Tetraethylthiuram disulfide is

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/08
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.