Deferasirox (ICL670): Mechanism of Action

Deferasirox (ICL670) MOA:Targeting Free Iron/ROS Signaling Pathway for Iron Overload and Chelation Therapy

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Deferasirox (ICL670) is a potent iron chelator. It affects PI3K/AKT/mTOR and STAT1 signaling pathways by binding to intracellular iron and depleting iron stores, effectively inhibiting cancer cell proliferation, stemness, and inducing apoptosis.

Primary Applications and Mechanism of Action