Decitabine is a potent, covalent DNA methyltransferase (DNMT) inhibitor. It affects PI3K/AKT/mTOR and Wnt/β-catenin signaling by incorporating into DNA to induce global hypomethylation, effectively reactivating silenced tumor suppressor genes, promoting apoptosis, and inhibiting cancer cell proliferation.
Decitabine IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Decitabine Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.