CAS No. 2353-33-5
| IUPAC Name | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one | |
|---|---|---|
| CAS Number | 2353-33-5 | |
| Molecular Formula |
C8H12N4O4 |
|
| Molecular Weight (MW) | 228.21 | |
| SMILES | C1C(C(OC1N2C=NC(=NC2=O)N)CO)O | |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
Decitabine is a nucleoside-based DNA methyltransferase (DNMT) inhibitor that incorporates into DNA, leading to DNA hypomethylation and depletion of DNMT activity. Incorporation of decitabine into genomic DNA triggers the formation of covalent protein-DNA adducts, blocking DNA replication and inducing cell cycle arrest during intra-S-phase. These downstream events ultimately trigger apoptosis and suppress the proliferation of various human cancer cell lines. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
45 mg/mL
(197.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 22.5 mg/mL |
| Ethanol | Insoluble |
| DMSO |
45 mg/mL
(197.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 45 mg/mL |
| Ethanol | Insoluble |
| DMSO |
46 mg/mL
(201.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
| DMSO |
46 mg/mL
(201.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | Insoluble |
| DMSO |
46 mg/mL
(201.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 46 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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