Clinical Trials

Decitabine is evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, investigating its utility in myelodysplastic syndromes, acute myeloid leukemia, malignant mesothelioma, and sickle cell disease, alongside safety assessments in healthy volunteers. Supported by major academic and pharmaceutical sponsors including the National Cancer Institute, Novo Nordisk A/S, and AbbVie, these programs span diverse recruitment statuses from actively recruiting to completed studies. Together, these efforts underscore extensive research evaluating decitabine across oncology and hematology.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07437950 RECRUITING
Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2027-04-18 PHASE2
NCT03013998 RECRUITING
Previously Untreated Relapsed Refractory Acute Myeloid Leukemia
Beat AML, LLC
 2016-11 PHASE2; PHASE3
NCT07389239 NOT_YET_RECRUITING
Ovarian Cancer; Advanced Malignant Solid Tumor
University of Chicago
 2026-06-23 PHASE1; PHASE2
NCT07710534 NOT_YET_RECRUITING
Relapsed / Refractory AML; High Risk Myelodysplastic Syndrome; High Risk Myeloproliferative Neoplasms
Virginia Commonwealth University
 2026-09-30 PHASE2
NCT07472322 NOT_YET_RECRUITING
Merkel Cell Carcinoma; Merkel Cell Carcinoma, Stage III; Merkel Cell Carcinoma, Stage IV
University of Wisconsin, Madison
 2026-09 PHASE1; PHASE2
NCT03418038 RECRUITING
Clonal Cytopenia of Undetermined Significance; High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Lymphoma; Chronic Myelomonocytic Leukemia
Mayo Clinic
 2018-03-23 PHASE2
NCT05983276 RECRUITING
Ovarian Cancer
Loyola University
 2023-11-16 PHASE2
NCT07238686 RECRUITING
Myelodysplastic Syndromes
Beijing 302 Hospital
 2025-06-20 PHASE2
NCT07153497 NOT_YET_RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndrome
National Cancer Institute (NCI)
 2026-05-27 PHASE2
NCT07435636 NOT_YET_RECRUITING
Clonal Cytopenia of Uncertain Significance; CCUS Clonal Cytopenia of Undetermined Significance; Clonal Hematopoiesis
Clinical Hub for Interventional Research (CHOIR)
 2026-04-13 PHASE2
NCT06972641 RECRUITING
AML; MDS
Ruijin Hospital
 2025-06-10 PHASE2; PHASE3
NCT07617363 NOT_YET_RECRUITING
Acute Myeloid Leukemia; High-risk Myelodysplastic Syndrome
Washington University School of Medicine
 2026-08-31 PHASE1
NCT06561074 RECRUITING
T-cell Acute Lymphoblastic Leukemia; T-Cell Lymphoblastic Lymphoma
M.D. Anderson Cancer Center
 2025-09-25 PHASE2
NCT07493330 NOT_YET_RECRUITING
PTCL; Refractory
Ruijin Hospital
 2026-03-23 PHASE1; PHASE2
NCT05766514 WITHDRAWN
Acute Myeloid Leukemia; Myelodysplastic Syndromes
University of Florida
 2025-04 PHASE2
NCT05740449 WITHDRAWN
Acute Lymphoblastic Leukemia, in Relapse; Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent; Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent; Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory; Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
Princess Maxima Center for Pediatric Oncology
 2023-10-01 PHASE1; PHASE2
NCT07511062 NOT_YET_RECRUITING
Acute Myeloid Leukemia; TP53 Gene Mutation
Northside Hospital, Inc.
 2026-08-01 PHASE1
NCT07762508 NOT_YET_RECRUITING
Leukemia, Myeloid, Acute(AML); Hematopoietic Stem Cell Transplantation (HSCT)
The First Affiliated Hospital of Soochow University
 2026-08
NCT07594899 NOT_YET_RECRUITING
Large B-Cell Lymphoma (LBCL)
Ruijin Hospital
 2026-05-06 PHASE2
NCT05564390 RECRUITING
Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm; Acute Myeloid Leukemia Post Cytotoxic Therapy; Acute Myeloid Leukemia, Myelodysplasia-Related; Myelodysplastic Syndrome
National Cancer Institute (NCI)
 2024-06-18 PHASE2
NCT07507760 RECRUITING
Acute Myeloid Leukemia With Gene Mutations
PETHEMA Foundation
 2026-06-12 PHASE2
NCT07148947 RECRUITING
Accelerated Phase Myeloproliferative Neoplasm; Blast Phase Myeloproliferative Neoplasm
University of Washington
 2026-03-02 PHASE2
NCT06802523 SUSPENDED
Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2026-11-18 PHASE1
NCT07177079 RECRUITING
Acute Myeloid Leukemia
Kittika Poonsombudlert
 2026-03-18 PHASE1
NCT06191978 RECRUITING
Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2024-03-07 PHASE1
NCT07060001 NOT_YET_RECRUITING
Acute Myeloid Leukemia (AML); Acute Myeloid Leukaemia (AML)
The Methodist Hospital Research Institute
 2026-04 PHASE2
NCT07555405 NOT_YET_RECRUITING
MAGT1 Deficiency
Children's Hospital of Fudan University
 2026-04 PHASE4
NCT00801489 RECRUITING
Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; de Novo Myelodysplastic Syndrome; High Risk Myelodysplastic Syndrome; Inv(16); Myelodysplastic Syndrome With Excess Blasts; t(16;16); t(8;21); Untreated Adult Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2007-04-04 PHASE2
NCT04655755 ACTIVE_NOT_RECRUITING
Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome
M.D. Anderson Cancer Center
 2021-01-19 PHASE1; PHASE2
NCT05960773 RECRUITING
Mesothelioma; Malignant Mesothelioma (MM); Early-stage Mesothelioma; Subclinical Mesothelioma; BRCA1-Associated Protein-1 (BAP1) Mutations; Early-stage BAP1-associated Malignancies
National Cancer Institute (NCI)
 2024-01-31 PHASE2
NCT06484062 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome/Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic Syndrome/Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic Syndrome/Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2025-08-15 PHASE1
NCT06930651 RECRUITING
Myeloid Malignancies
M.D. Anderson Cancer Center
 2025-09-03 PHASE1; PHASE2
NCT07283094 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Montefiore Medical Center
 2026-02-03 PHASE1
NCT06803693 RECRUITING
Diffuse Large B-Cell Lymphoma
Ruijin Hospital
 2025-04-01 PHASE2
NCT06928662 RECRUITING
Acute Myeloid Leukemia; Acute Undifferentiated Leukemia; Mixed Phenotype Acute Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Acute Undifferentiated Leukemia; Recurrent Chronic Myelomonocytic Leukemia; Recurrent Mixed Phenotype Acute Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Acute Undifferentiated Leukemia; Refractory Chronic Myelomonocytic Leukemia; Refractory Mixed Phenotype Acute Leukemia; Refractory Myelodysplastic Syndrome; Secondary Acute Myeloid Leukemia
Fred Hutchinson Cancer Center
 2025-09-23 PHASE1; PHASE2
NCT04245397 RECRUITING
Myelodysplastic Syndromes
Syntrix Biosystems, Inc.
 2020-06-30 PHASE1
NCT07505160 NOT_YET_RECRUITING
Acute Myeloid Leukemia (AML)
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2026-03 PHASE2
NCT05201066 ACTIVE_NOT_RECRUITING
Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic
Novartis Pharmaceuticals
 2023-02-28 PHASE2
NCT01515527 RECRUITING
Leukemia
M.D. Anderson Cancer Center
 2012-02-07 PHASE2
NCT05010122 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2021-07-08 PHASE1; PHASE2
NCT03661307 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2018-10-31 PHASE1; PHASE2
NCT07101588 RECRUITING
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Chinese PLA General Hospital
 2025-01-01 PHASE4
NCT07706959 NOT_YET_RECRUITING
Peripheral T-cell Lymphoma (PTCL)
Ruijin Hospital
 2026-07 PHASE1; PHASE2
NCT07052422 NOT_YET_RECRUITING
Older Patients; Myeloid Malignancies; Conditioning; Hematopoietic Stem Cell Transplantation (HSCT)
Nanfang Hospital, Southern Medical University
 2025-07-15 PHASE2; PHASE3
NCT03132454 ACTIVE_NOT_RECRUITING
Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2017-07-25 PHASE1
NCT06661915 RECRUITING
Accelerated Phase Myeloproliferative Neoplasm; Blast Phase Myeloproliferative Neoplasm; Essential Thrombocythemia; Myelodysplastic/Myeloproliferative Neoplasm; Myeloproliferative Neoplasm, Not Otherwise Specified; Polycythemia Vera; Primary Myelofibrosis; Secondary Myelofibrosis
National Cancer Institute (NCI)
 2025-08-14 PHASE2
NCT07691632 NOT_YET_RECRUITING
Locally Advanced Colorectal Cancer; Colorectal Adenocarcinoma
Tianjin Medical University Cancer Institute and Hospital
 2026-06-30 PHASE2
NCT06441097 NOT_YET_RECRUITING
Diffuse Large B-Cell Lymphoma
Ruijin Hospital
 2024-12-31 PHASE2
NCT03844815 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
University of Chicago
 2019-11-18 PHASE1
NCT02781883 RECRUITING
Acute Myeloid Leukemia (AML)
Bio-Path Holdings, Inc.
 2016-05 PHASE2
NCT05586074 RECRUITING
Leukemia, Acute Myeloid (AML)
Sunshine Lake Pharma Co., Ltd.
 2023-03-03 PHASE3
NCT04774393 RECRUITING
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2021-05-24 PHASE1; PHASE2
NCT06997094 RECRUITING
Human Papillomavirus-Negative Neck Squamous Cell Carcinoma; Resectable Head and Neck Squamous Cell Carcinoma; Resectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma; HPV-Negative Squamous Cell Carcinoma; Resectable Head and Neck Squamous-cell Carcinoma
Mayo Clinic
 2026-01-23 PHASE1
NCT06686108 RECRUITING
T-cell Acute Lymphoblastic Leukemia; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; Relapse
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
 2024-10-30 PHASE2
NCT07374029 RECRUITING
Acute Myeloid Leukemia; Acute Myeloid Leukemia, in Relapse
David Avigan
 2026-02-12 PHASE1
NCT06923488 RECRUITING
Myelodysplastic Syndromes
West Virginia University
 2025-07-15 PHASE1; PHASE2
NCT06511882 RECRUITING
Acute Myeloid Leukemia
H. Lee Moffitt Cancer Center and Research Institute
 2024-11-07 PHASE2
NCT05600894 ACTIVE_NOT_RECRUITING
Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Myelodysplastic/Myeloproliferative Neoplasm; Myeloproliferative Neoplasm
National Cancer Institute (NCI)
 2023-06-27 PHASE2
NCT06712121 RECRUITING
T Lymphoblastic Leukemia/Lymphoma
Seoul National University Hospital
 2025-01-30 PHASE2
NCT07216833 WITHDRAWN
Head and Neck Cancer; Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma
Case Comprehensive Cancer Center
 2026-01 PHASE1
NCT03969446 SUSPENDED
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
City of Hope Medical Center
 2020-05-04 PHASE1
NCT06429098 RECRUITING
Acute Myeloid Leukemia
The First Affiliated Hospital of Soochow University
 2024-01-01 PHASE2
NCT03041688 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2018-02-08 PHASE1
NCT06445959 RECRUITING
Mutant IDH1 Inhibitor Olutasidenib
M.D. Anderson Cancer Center
 2024-08-29 PHASE1; PHASE2
NCT03184935 SUSPENDED
Myelodysplastic Syndromes
Sclnow Biotechnology Co., Ltd.
 2026-12-31 PHASE1; PHASE2
NCT05272384 RECRUITING
Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Hodgkin Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Hodgkin Lymphoma
National Cancer Institute (NCI)
 2022-11-03 PHASE1
NCT06393361 RECRUITING
Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Chinese PLA General Hospital
 2024-06-01 PHASE2
NCT04975919 ACTIVE_NOT_RECRUITING
Recurrent Acute Biphenotypic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Biphenotypic Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2021-09-29 PHASE2
NCT06383572 RECRUITING
Lymphodepleting Chemotherapy; Myeloid Malignancies
M.D. Anderson Cancer Center
 2024-06-26 PHASE1; PHASE2
NCT06672146 RECRUITING
Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2025-05-16 PHASE2
NCT07012044 RECRUITING
Acute Myeloid Leukemia Post Cytotoxic Therapy; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2026-06-09 PHASE1
NCT05222984 ACTIVE_NOT_RECRUITING
Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
City of Hope Medical Center
 2022-07-29 PHASE1
NCT06577441 RECRUITING
Myelodysplastic Syndrome
National Cancer Institute (NCI)
 2025-06-12 PHASE2
NCT05190471 RECRUITING
Acute Myeloid Leukemia, in Relapse; Acute Myeloid Leukemia Refractory
Bio-Path Holdings, Inc.
 2022-08-16 PHASE1
NCT06327685 RECRUITING
Systemic Mastocytosis With an Associated Hematologic Neoplasm
H. Lee Moffitt Cancer Center and Research Institute
 2024-03-13 PHASE1
NCT05673200 SUSPENDED
Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Unresectable Triple-Negative Breast Carcinoma
National Cancer Institute (NCI)
 2023-09-25 PHASE1
NCT04874480 ACTIVE_NOT_RECRUITING
Recurrent Leukemia; Refractory Leukemia
M.D. Anderson Cancer Center
 2021-09-27 PHASE1
NCT05038592 ACTIVE_NOT_RECRUITING
Chronic Myelomonocytic Leukemia; Chronic Myelomonocytic Leukemia-1; Chronic Myelomonocytic Leukemia-2; Myelodysplastic/Myeloproliferative Neoplasm
M.D. Anderson Cancer Center
 2022-03-04 PHASE1; PHASE2
NCT06401603 RECRUITING
Advanced Chronic Myeloid Leukemia; Philadelphia Chromosome-Positive Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2024-08-06 PHASE1
NCT05010772 RECRUITING
Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2021-10-25 PHASE1
NCT06651866 RECRUITING
Acute Myeloid Leukemia
The First Affiliated Hospital of Xiamen University
 2024-12-12 PHASE1
NCT07007767 NOT_YET_RECRUITING
Colorectal Cancer Metastatic
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
 2025-06-15 PHASE2
NCT06499025 ENROLLING_BY_INVITATION
AML; t(8;21); Neoantigen
BGI, China
 2024-02-01 EARLY_PHASE1
NCT07006025 RECRUITING
MDS
Treebough Therapies
 2025-06-03 PHASE1
NCT06572631 WITHDRAWN
Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
City of Hope Medical Center
 2025-06-07 PHASE1
NCT06701357 RECRUITING
DLBCL
Ruijin Hospital
 2024-12-10 PHASE2
NCT05360160 RECRUITING
Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2022-10-14 PHASE1; PHASE2
NCT06750991 NOT_YET_RECRUITING
DLBCL
Ruijin Hospital
 2024-12-31 PHASE2
NCT07712848 RECRUITING
AML (Acute Myeloid Leukemia)
The Second Affiliated Hospital of Kunming Medical University
 2026-04-01 PHASE3
NCT06379360 RECRUITING
Acute Myeloid Leukemia
The First Affiliated Hospital of Soochow University
 2020-11-01 PHASE2
NCT04953910 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Taiho Oncology, Inc.
 2022-12-23 PHASE1
NCT07044544 RECRUITING
Myeloid Malignancy; Hematologic Malignancy; Acute Myeloid Leukemia; Myelodysplastic Syndromes
University of Alabama at Birmingham
 2025-07-17 PHASE1
NCT06129734 RECRUITING
Myeloid Malignancy; Acute Myeloid Leukemia
Benjamin Tomlinson
 2025-07-28 PHASE1; PHASE2
NCT04953897 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Taiho Oncology, Inc.
 2021-12-15 PHASE1
NCT04282187 RECRUITING
Acute Myeloid Leukemia; Essential Thrombocythemia; Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasm; Myeloproliferative Neoplasm; Myeloproliferative Neoplasm, Not Otherwise Specified; Polycythemia Vera; Primary Myelofibrosis; Secondary Myelofibrosis
University of Washington
 2020-03-24 PHASE2
NCT04187703 RECRUITING
Myelodysplastic Syndromes; MDS/MPN Crossover Syndromes
Benjamin Tomlinson
 2020-11-16 EARLY_PHASE1
NCT06741722 RECRUITING
AML; Relapsed Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
Beijing 302 Hospital
 2024-10-31 PHASE2
NCT04746235 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2021-02-22 PHASE2
NCT04055818 RECRUITING
Sickle Cell Disease
EpiDestiny, Inc.
 2020-01-24 PHASE1
NCT05007873 ACTIVE_NOT_RECRUITING
Chronic Phase Chronic Myelogenous Leukemia; Philadelphia Chromosome Positive; BCR-ABL1 Positive Chronic Myelogenous Leukemia; BCR-ABL1 Positive
M.D. Anderson Cancer Center
 2021-10-21 PHASE2
NCT07163793 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia in Remission
Northwell Health
 2024-10-07 PHASE2
NCT03875287 ACTIVE_NOT_RECRUITING
Solid Tumor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2019-04-17 PHASE1
NCT06563778 NOT_YET_RECRUITING
Ineligible Or Refused Transplant Patients With Classical Hodgkin Lymphoma
Chinese PLA General Hospital
 2024-09-01 PHASE2
NCT06156579 RECRUITING
AML; MDS
University Hospital Tuebingen
 2023-11-04 PHASE2
NCT02998567 ACTIVE_NOT_RECRUITING
Non Small Cell Lung Cancer
Royal Marsden NHS Foundation Trust
 2017-01-26 PHASE1
NCT06337331 WITHDRAWN
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Northside Hospital, Inc.
 2024-08-31 PHASE2
NCT05636514 RECRUITING
Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; Acute Myeloid Leukemia
Clinical Hub for Interventional Research (CHOIR)
 2022-12-14 PHASE1
NCT05796570 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndromes; Myeloid Malignancies; MDS; Inherited Bone Marrow Failure Syndrome; Myeloid Neoplasm; Aml
Franziska Wachter
 2023-04-19 PHASE2
NCT05089370 ACTIVE_NOT_RECRUITING
Malignant Melanoma
University of Colorado, Denver
 2022-06-20 PHASE1; PHASE2
NCT05669079 NOT_YET_RECRUITING
Poor Graft Function
The First Affiliated Hospital of Soochow University
 2023-08-01 PHASE3
NCT06536959 RECRUITING
Relapsed Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Myelodysplastic Syndromes; Minimal Residual Disease
Beijing 302 Hospital
 2024-07-18 PHASE2
NCT05907499 NOT_YET_RECRUITING
Poor Graft Function
The First Affiliated Hospital of Soochow University
 2023-07-01 PHASE3
NCT07348575 ENROLLING_BY_INVITATION
Lymphoma, Large-Cell, Diffuse
Second Affiliated Hospital of Nanchang University
 2024-07-01 PHASE3
NCT04482621 SUSPENDED
COVID-19
Johns Hopkins University
 2020-09-14 PHASE2
NCT06827899 RECRUITING
Acute Myeloid Leukemia
The First Affiliated Hospital of Xiamen University
 2022-07-01 PHASE2
NCT04188405 COMPLETED
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Myeloid Leukemia; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Acute Myeloid Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
M.D. Anderson Cancer Center
 2020-05-17 PHASE2
NCT05351346 UNKNOWN
Diffuse Large B Cell Lymphoma
Ruijin Hospital
 2022-06-01 PHASE3
NCT06091267 ACTIVE_NOT_RECRUITING
Myelodysplastic Syndromes
Otsuka Beijing Research Institute
 2023-10-16 PHASE1; PHASE2
NCT03613532 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia (AML); Myelodysplastic Syndrome (MDS); Chronic Myelomonocytic Leukemia (CMML); MDS/Myeloproliferative Neoplasm-unclassifiable (MDS/MPN-unclassifiable); Hematopoietic Stem Cell Transplant
Jacqueline Garcia, MD
 2018-10-24 PHASE1
NCT06683885 RECRUITING
Newly Diagnosed Diffuse Large B-cell Lymphoma
Mingzhi Zhang
 2024-11-20 PHASE1; PHASE2
NCT02961101 RECRUITING
Malignancies Multiple
Han weidong
 2016-05 PHASE1; PHASE2
NCT06393985 RECRUITING
B-cell Acute Lymphoblastic Leukemia
The First Affiliated Hospital of Soochow University
 2024-04-25 PHASE2
NCT03679650 ACTIVE_NOT_RECRUITING
Acute Myelogenous Leukemia
Beth Israel Deaconess Medical Center
 2018-10-11 PHASE1
NCT03009240 COMPLETED
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
City of Hope Medical Center
 2017-08-21 PHASE1
NCT03404193 TERMINATED
Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Blastic Plasmacytoid Dendritic Cell Neoplasm; Chronic Myelomonocytic Leukemia; Mixed Phenotype Acute Leukemia; Myelodysplastic Syndrome; Recurrent Acute Biphenotypic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm; Recurrent Chronic Myelomonocytic Leukemia; Recurrent Mixed Phenotype Acute Leukemia; Refractory Acute Myeloid Leukemia; Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm; Refractory Chronic Myelomonocytic Leukemia; Refractory Mixed Phenotype Acute Leukemia
M.D. Anderson Cancer Center
 2018-01-18 PHASE2
NCT06297772 NOT_YET_RECRUITING
AML, Adult
Ruijin Hospital
 2024-06-01 PHASE3
NCT06316960 RECRUITING
AML, Childhood; Relapse/Recurrence; Refractory AML; Core Binding Factor Acute Myeloid Leukemia; C-KIT Mutation
Children's Hospital of Soochow University
 2024-03-01 PHASE2
NCT07117422 RECRUITING
AML, Adult
The Second Hospital of Hebei Medical University
 2025-01-17
NCT03926624 TERMINATED
Leukemia, Myeloid, Acute
Delta-Fly Pharma, Inc.
 2019-11-22 PHASE3
NCT05829226 COMPLETED
AML, Adult Recurrent; MDS
PureTech
 2022-12-12 PHASE1
NCT05230368 COMPLETED
HIV-1-infection, Subtype b
ANRS, Emerging Infectious Diseases
 2022-12-14 PHASE1
NCT06284460 WITHDRAWN
Pathway Mutant Myelodysplastic Syndromes; Myelodysplastic Neoplasm; Myeloproliferative Neoplasm
M.D. Anderson Cancer Center
 2025-01-31 PHASE1; PHASE2
NCT04229979 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
Sellas Life Sciences Group
 2021-02-08 PHASE3
NCT06046313 RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndromes
First Affiliated Hospital of Zhejiang University
 2023-10-19 PHASE2
NCT03164057 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Myelodysplastic Syndromes
St. Jude Children's Research Hospital
 2017-06-15 PHASE2
NCT02204085 COMPLETED
Acute Myeloid Leukemia, in Relapse; Recurrent Adult Acute Myeloid Leukemia
Beth Israel Deaconess Medical Center
 2014-09 PHASE1; PHASE2
NCT04891757 ACTIVE_NOT_RECRUITING
Advanced Hematologic Malignancy; Relapsed Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Relapsed Myelodysplastic Syndromes; Refractory Myelodysplastic Syndromes; Relapsed Chronic Myelomonocytic Leukemia; Refractory Chronic Myelomonocytic Leukemia
Foghorn Therapeutics Inc.
 2021-06-14 PHASE1
NCT06474663 WITHDRAWN
Refractory Acute Leukemia; Relapsed Acute Leukemia
M.D. Anderson Cancer Center
 2025-07-31 PHASE1
NCT05405114 COMPLETED
Sickle Cell Disease
Novo Nordisk A/S
 2022-07-07 PHASE2
NCT03240211 ACTIVE_NOT_RECRUITING
PTCL; CTCL
University of Virginia
 2022-02-02 PHASE1
NCT04945096 UNKNOWN
Engraft Failure; Relapse; GVHD
The First Affiliated Hospital of Soochow University
 2021-07-01 PHASE3
NCT04817241 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2022-02-10 PHASE1; PHASE2
NCT05348213 RECRUITING
Diffuse Large B Cell Lymphoma
Ruijin Hospital
 2022-05-16 PHASE2
NCT06454448 RECRUITING
Adebrelimab (SHR-1316); Decitabine; Metastatic Pancreatic Cancer
Tianjin Medical University Cancer Institute and Hospital
 2024-06-15 PHASE1; PHASE2
NCT04697940 ACTIVE_NOT_RECRUITING
Relapsed and Refractory B-cell Non-Hodgkin's Lymphoma; Decitabine-primed Tandem CD19/CD20 CAR T Cells
Han weidong
 2021-04-15 PHASE1; PHASE2
NCT04905810 RECRUITING
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia
Brian Jonas
 2022-02-09 PHASE2
NCT03974217 ACTIVE_NOT_RECRUITING
Leukemia
Dana-Farber Cancer Institute
 2019-08-01 PHASE1
NCT05918055 TERMINATED
Myelodysplastic Syndromes
National Cancer Institute (NCI)
 2023-11-14 PHASE1; PHASE2
NCT05816746 UNKNOWN
Diffuse Large B Cell Lymphoma; Relapse/Recurrence; Extranodal Extension; Central Nervous System Lymphoma
Chinese PLA General Hospital
 2023-05-15 PHASE2
NCT06357858 WITHDRAWN
Recurrent Squamous Cell Carcinoma of the Head and Neck; Metastatic Squamous Cell Carcinoma; Head and Neck Squamous Cell Carcinoma
Case Comprehensive Cancer Center
 2024-06-01 PHASE1
NCT05717621 COMPLETED
Vulvar Intraepithelial Neoplasia Grade 2; Vulvar Intraepithelial Neoplasia Grade 3
ViMREX GmbH
 2023-03-28 PHASE1
NCT05841771 UNKNOWN
Hypomethylating Agent; Venetoclax; Myeloid Malignancy
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
 2023-01-01 PHASE2
NCT05376852 UNKNOWN
Chronic Myeloid Leukemia in Myeloid Blast Crisis; Chronic Myeloid Leukaemia Transformation; Chronic Myeloid Leukemia - Accelerated Phase; Chronic Myeloid Leukemia in Lymphoid Blast Crisis
Nanfang Hospital, Southern Medical University
 2021-12-01 PHASE2
NCT05037500 TERMINATED
Castration-Resistant Prostate Carcinoma; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
Roswell Park Cancer Institute
 2022-01-26 PHASE1
NCT05403450 TERMINATED
Relapsed/Refractory Peripheral T-cell Lymphoma
Taiho Oncology, Inc.
 2023-02-22 PHASE1
NCT05883956 ACTIVE_NOT_RECRUITING
Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Patient Preference
Otsuka Australia Pharmaceutical Pty Ltd
 2023-12-20 PHASE3
NCT06073730 UNKNOWN
Elderly AML Patients; Unfit, New-diagnosis AML; Acute Myeloid Leukemia; Venetoclax; Decitabine
The Second Affiliated Hospital of Kunming Medical University
 2023-11-01 PHASE3
NCT04763928 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto
 2021-12-03 PHASE2
NCT05360264 TERMINATED
Pancreatic Adenocarcinoma Metastatic; Pancreatic Adenocarcinoma Recurrent
Luca Cardone
 2022-01-15 PHASE2
NCT04657081 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
Taiho Oncology, Inc.
 2021-02-09 PHASE1; PHASE2
NCT03019003 COMPLETED
Head and Neck Cancer
Massachusetts General Hospital
 2017-03-20 PHASE1
NCT05799079 TERMINATED
Recurrent Acute Myeloid Leukemia
Sanjay Mohan
 2023-04-13 PHASE2
NCT06941688 TERMINATED
Peripheral T-cell Lymphoma (PTCL)
Seoul National University Hospital
 2020-11-13 PHASE2
NCT02269280 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2014-10-13 PHASE2
NCT06297629 WITHDRAWN
Allogeneic Stem Cell Transplantation
M.D. Anderson Cancer Center
 2024-07-01 PHASE2
NCT05805072 UNKNOWN
Relapsed/Refractory AML
The First Affiliated Hospital of Soochow University
 2023-05-01
NCT04485052 SUSPENDED
Acute Myeloid Leukemia
Innovent Biologics (Suzhou) Co. Ltd.
 2020-09-25 PHASE1; PHASE2
NCT06291285 COMPLETED
Healthy Volunteers
Novo Nordisk A/S
 2024-02-27 PHASE1
NCT05396859 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
OHSU Knight Cancer Institute
 2022-10-28 PHASE1
NCT02159820 UNKNOWN
Primary Malignant Neoplasm of Ovary; FIGO Stages II to IV
Chinese PLA General Hospital
 2014-06 PHASE2; PHASE3
NCT05564650 COMPLETED
Myelodysplastic Syndrome; Recurrent Myelodysplastic Syndrome; Refractory Myelodysplastic Syndrome
Thomas Jefferson University
 2023-01-12 PHASE1
NCT05455294 ACTIVE_NOT_RECRUITING
Myeloid Malignancy; Myelodysplastic Syndromes; Myelofibrosis; Acute Myeloid Leukemia; Myeloproliferative Neoplasm
Jacqueline Garcia, MD
 2022-07-18 PHASE1
NCT04283526 WITHDRAWN
Primary Myelofibrosis; Myelofibrosis; PMF; Post-Essential Thrombocythemia Myelofibrosis; Post-Polycythemia Vera Myelofibrosis
Novartis Pharmaceuticals
 2020-11-30 PHASE1
NCT05524857 TERMINATED
Myeloproliferative Neoplasm
Joseph Jurcic
 2022-01-28 PHASE1
NCT04337606 UNKNOWN
Non Hodgkin Lymphoma
Chinese PLA General Hospital
 2020-04-04 PHASE1; PHASE2
NCT05320640 UNKNOWN
Relapsed/Refractory Non-Hodgkin Lymphoma; Advanced Solid Tumors
Chinese PLA General Hospital
 2022-03-30 PHASE1; PHASE2
NCT06351306 WITHDRAWN
Acute Myeloid Leukemia
Columbia University
 2024-04-01 PHASE2
NCT03226418 COMPLETED
Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia
University of Nebraska
 2017-07-07 PHASE2
NCT05177731 ACTIVE_NOT_RECRUITING
AML, Adult; Chemotherapy Effect
Chen Suning
 2022-03-01 PHASE3
NCT04340843 ACTIVE_NOT_RECRUITING
Locally Advanced Unresectable Primary Central Chondrosarcoma; Metastatic Primary Central Chondrosarcoma; Unresectable Primary Central Chondrosarcoma
National Cancer Institute (NCI)
 2020-09-08 PHASE2
NCT04233294 UNKNOWN
Hodgkin Lymphoma
Chinese PLA General Hospital
 2020-02-02 PHASE2
NCT05143125 UNKNOWN
Malignancy
Shenzhen University General Hospital
 2021-02-05 PHASE1; PHASE2
NCT06291285 Not yet recruiting
Healthy Volunteers
Novo Nordisk A/S
 2024-02-27 Phase 1
NCT05382390 UNKNOWN
Acute Myeloid Leukemia
Huihan Wang
 2022-01-21 PHASE3
NCT03063944 COMPLETED
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2017-03-17 PHASE1
NCT04985656 WITHDRAWN
Myelodysplastic Syndromes (MDS)
Takeda
 2021-10-01 PHASE2
NCT05960773 Recruiting
Mesothelioma|Malignant Mesothelioma (MM)|Early-stage Mesothelioma|Subclinical Mesothelioma|BRCA1-Associated Protein-1 (BAP1) Mutations|Early-stage BAP1-associated Malignancies
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 2024-01-31 Phase 2
NCT05137886 UNKNOWN
Hodgkin Lymphoma, Adult; Relapse; Refractory Hodgkin Lymphoma
Institute of Hematology & Blood Diseases Hospital, China
 2022-01 PHASE2
NCT05638984 UNKNOWN
PFS
Fudan University
 2023-01-01 PHASE2
NCT05265962 UNKNOWN
Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
 2022-12-01 PHASE2
NCT05184842 RECRUITING
Myelodysplastic Syndromes; Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia
Montefiore Medical Center
 2022-03-23 PHASE2
NCT04655391 WITHDRAWN
Recurrent Acute Myeloid Leukemia
City of Hope Medical Center
 2022-06-25 PHASE1
NCT05453552 UNKNOWN
Myelodysplastic Syndrome; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning
Nanfang Hospital, Southern Medical University
 2022-07-01 PHASE2; PHASE3
NCT03026842 UNKNOWN
Acute Myeloid Leukemia
The First Hospital of Jilin University
 2017-01 PHASE4
NCT05449899 UNKNOWN
Secondary Acute Myeloid Leukemia Evolving From MDS; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning
Nanfang Hospital, Southern Medical University
 2022-07 PHASE2; PHASE3
NCT03445858 COMPLETED
Childhood Solid Tumor; Childhood Lymphoma; Relapsed Cancer; Refractory Cancer; Adult Solid Tumor; Adult Lymphoma
Children's Hospital Medical Center, Cincinnati
 2018-02-12 EARLY_PHASE1
NCT04878432 TERMINATED
Myelodysplastic Syndrome (MDS)
Novartis Pharmaceuticals
 2022-03-17 PHASE2
NCT03793517 RECRUITING
Stem Cell Transplant Complications; Leukemia, Myeloid, Acute; Leukemia Relapse
Peking University People's Hospital
 2018-09-01 PHASE2; PHASE3
NCT04113616 TERMINATED
Relapsed or Refractory Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia (AML), Secondary to Myeloproliferative Neoplasms (MPN)
Kartos Therapeutics, Inc.
 2019-09-25 PHASE1; PHASE2
NCT03066648 COMPLETED
Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Preleukemia; Bone Marrow Diseases; Hematologic Diseases; Chronic Myelomonocytic Leukemia
Novartis Pharmaceuticals
 2017-07-06 PHASE1
NCT04582604 UNKNOWN
Peripheral Blood Stem Cell Transplantation
Chinese PLA General Hospital
 2020-09-01 PHASE1; PHASE2
NCT05426798 UNKNOWN
Recurrent/Refractory Acute Myeloid Leukemia, Myelodysplastic Syndromes
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2022-04-29 PHASE1
NCT05456269 WITHDRAWN
Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Higher Risk Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia
Racura Oncology Ltd
 2022-07-29 PHASE1
NCT04980404 ACTIVE_NOT_RECRUITING
Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; Stem Cell Leukemia
Massachusetts General Hospital
 2021-09-17 PHASE1
NCT05835011 TERMINATED
Myelodysplastic Syndromes
Astex Pharmaceuticals, Inc.
 2023-06-27 PHASE2
NCT03092674 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome/Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2018-02-02 PHASE2; PHASE3
NCT04713956 UNKNOWN
Myelodysplastic Syndrome; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning
Nanfang Hospital, Southern Medical University
 2021-01-15 PHASE2; PHASE3
NCT04672473 UNKNOWN
Malignant Tumor
Shenzhen University General Hospital
 2020-10-30 PHASE1; PHASE2
NCT05835011 Terminated
Myelodysplastic Syndromes
Astex Pharmaceuticals Inc.
 2023-07-14 Phase 2
NCT03855371 UNKNOWN
P53 Mutation; Myeloid Malignancy; MDS; Aml
Ruijin Hospital
 2018-01-10 PHASE1
NCT05816356 COMPLETED
Healthy
EpiDestiny, Inc.
 2023-03-24 PHASE1
NCT05264883 UNKNOWN
Acute Myeloid Leukemia
The First Affiliated Hospital with Nanjing Medical University
 2021-03-01 PHASE3
NCT05362942 UNKNOWN
Relapsed Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Minimal Residual Disease
Beijing 302 Hospital
 2022-05-01 PHASE2
NCT03709550 WITHDRAWN
Castration Levels of Testosterone; Castration-Resistant Prostate Carcinoma; Metastatic Prostate Carcinoma in the Soft Tissue; Prostate Carcinoma Metastatic in the Bone; PSA Level Greater Than or Equal to Two; PSA Progression; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
Roswell Park Cancer Institute
 2021-04-15 PHASE1; PHASE2
NCT07773909 COMPLETED
Acute Myeloid Leukemia
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2022-06-01 PHASE4
NCT05816356 Recruiting
Healthy
EpiDestiny Inc.|Worldwide Clinical Trials
 2023-03-24 Phase 1
NCT04476199 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia
Gruppo Italiano Trapianto di Midollo Osseo
 2019-12-09 PHASE2
NCT05148234 TERMINATED
Myelodysplastic Syndromes
National Cancer Institute (NCI)
 2022-11-29 PHASE1; PHASE2
NCT04292769 UNKNOWN
Malignant Neoplasm
Li Yu
 2020-01-21 PHASE3
NCT02632721 COMPLETED
Leukemia, Myeloid, Acute
Boehringer Ingelheim
 2016-06-16 PHASE1; PHASE2
NCT00382200 COMPLETED
Myelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center
 2006-07 PHASE1; PHASE2
NCT04446130 UNKNOWN
Induction Chemotherapy; Acute T-Lymphocytic Leukemia; T-cell Lymphoblastic Lymphoma Leukemia; T-cell/Myeloid Mixed Phenotype Acute Leukemia
The First Affiliated Hospital of Soochow University
 2019-01-01 PHASE3
NCT04279379 UNKNOWN
Extranodal NK/T-cell Lymphoma
Beijing Tongren Hospital
 2020-04-01 PHASE2
NCT02073838 COMPLETED
Acute Myeloid Leukemia
Sarit Assouline
 2015-05 PHASE2
NCT01812252 COMPLETED
Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndrome; Myelodysplastic Syndrome; Secondary Myelodysplastic Syndrome
Fred Hutchinson Cancer Center
 2013-08-19 PHASE2
NCT02890329 ACTIVE_NOT_RECRUITING
Previously Treated Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia, Myelodysplasia-Related; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome
National Cancer Institute (NCI)
 2017-09-05 PHASE1
NCT04055844 COMPLETED
Acute Myeloid Leukemia; Myeloid and Monocytic Leukemia; Myelodysplastic Syndromes
Masonic Cancer Center, University of Minnesota
 2020-02-17 PHASE2
NCT04123392 UNKNOWN
TP53; Myeloid Tumors; Conditioning; Allogeneic Hematopoietic Stem Cell Transplantation
Nanfang Hospital, Southern Medical University
 2019-10 PHASE2; PHASE3
NCT02608268 TERMINATED
Advanced Malignancies
Novartis Pharmaceuticals
 2015-11-23 PHASE1; PHASE2
NCT02957968 ACTIVE_NOT_RECRUITING
Breast Adenocarcinoma; Estrogen Receptor- Negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; HER2/Neu Negative; Invasive Breast Carcinoma; Progesterone Receptor Negative; Progesterone Receptor Positive Tumor; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Triple-negative Breast Carcinoma
Virginia Commonwealth University
 2017-01-24 PHASE2
NCT04514081 UNKNOWN
Hodgkin Lymphoma; Anti-PD-1 Antibody Resistant
Chinese PLA General Hospital
 2020-08-01 PHASE2
NCT04098653 UNKNOWN
Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning; Myeloid Tumors
Nanfang Hospital, Southern Medical University
 2019-09 PHASE2; PHASE3
NCT04854889 TERMINATED
Refractory Aplastic Anemia
Institute of Hematology & Blood Diseases Hospital, China
 2021-04-22 PHASE2
NCT03250962 UNKNOWN
Hodgkin Lymphoma
Chinese PLA General Hospital
 2017-09-11 PHASE2
NCT02203773 TERMINATED
Acute Myelogenous Leukemia; Myelogenous Leukemia; Treatment Naive AML
AbbVie
 2014-10-06 PHASE1
NCT02488408 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndromes
BerGenBio ASA
 2014-10-22 PHASE1; PHASE2
NCT04850560 UNKNOWN
Objective Response Rate
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2021-05-18 PHASE1
NCT03941964 COMPLETED
Acute Myeloid Leukemia (AML); Cancer
AbbVie
 2019-08-15 PHASE3
NCT02172872 UNKNOWN
Acute Myeloid Leukemia (AML)
European Organisation for Research and Treatment of Cancer - EORTC
 2014-11-28 PHASE3
NCT03417427 UNKNOWN
Leukemia, Myeloid
Xuejie Jiang
 2018-02-01 PHASE2
NCT02109744 COMPLETED
Acute Myelogenous Leukemia
University of Rochester
 2014-03 PHASE1; PHASE2
NCT04510610 UNKNOWN
Hodgkin Lymphoma
Chinese PLA General Hospital
 2019-09-01 PHASE2; PHASE3
NCT03799224 UNKNOWN
Stem Cell Transplant Complications; Relapse Leukemia; Refractory Leukemia
Peking University People's Hospital
 2018-12-01 PHASE2; PHASE3
NCT04172844 TERMINATED
Acute Myelogenous Leukemia
Medical College of Wisconsin
 2020-01-13 PHASE1
NCT04752527 UNKNOWN
Acute Myeloid Leukemia, Adult
The First Affiliated Hospital of Soochow University
 2021-02-20 PHASE2
NCT03467178 UNKNOWN
Recurrent, Platinum-resistant Ovarian Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
 2018-07-30 PHASE2
NCT03021395 WITHDRAWN
AML
Institute of Hematology & Blood Diseases Hospital, China
 2017-02-08 PHASE1; PHASE2
NCT03303339 COMPLETED
Acute Myeloid Leukemia
Cardiff Oncology
 2017-11-17 PHASE1; PHASE2
NCT04097470 ACTIVE_NOT_RECRUITING
AML/MDS
Stichting Hemato-Oncologie voor Volwassenen Nederland
 2019-12-05 PHASE2
NCT04146038 COMPLETED
Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myeloblasts 10 Percent or More of Bone Marrow Nucleated Cells; Myelodysplastic Syndrome; Myeloproliferative Neoplasm; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
Rutgers, The State University of New Jersey
 2020-10-26 PHASE2
NCT03233724 TERMINATED
Carcinoma, Non-Small-Cell Lung; Lung Cancer; Non-Small Cell Lung Cancer; Carcinoma, Esophageal; Malignant Pleural Mesotheliomas
National Cancer Institute (NCI)
 2018-04-11 PHASE1; PHASE2
NCT03080766 UNKNOWN
Acute Myeloid Leukemia; Complex Karyotype
The University of Hong Kong
 2017-03-01 PHASE2
NCT03306264 COMPLETED
Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc.
 2018-02-15 PHASE3
NCT04553393 UNKNOWN
Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden
Chinese PLA General Hospital
 2020-09-09 PHASE1; PHASE2
NCT03593915 TERMINATED
Myelodysplastic Syndromes (MDS)
Sumitomo Pharma America, Inc.
 2018-08-29 PHASE1; PHASE2
NCT02214407 COMPLETED
MDS
Groupe Francophone des Myelodysplasies
 2014-10-14 PHASE3
NCT04025593 UNKNOWN
Diffuse Large B Cell Lymphoma
Ruijin Hospital
 2019-07-17 PHASE2
NCT03553537 UNKNOWN
Peripheral T-cell Lymphoma
Southwest Hospital, China
 2018-06 PHASE3
NCT04049344 UNKNOWN
Metastatic Renal Cell Carcinoma
Zhejiang Cancer Hospital
 2019-08-15 PHASE2
NCT04252248 TERMINATED
Head and Neck Cancer; Anogenital Cancer
University Hospital Heidelberg
 2019-10-11 PHASE1
NCT03295552 TERMINATED
Breast Neoplasm
Shanghai Jiao Tong University School of Medicine
 2017-11-15 PHASE2
NCT03596892 UNKNOWN
Allogeneic Hematopoietic Stem Cell Transplantation; Conditions; Mixed-lineage-leukemia (MLL)-Rearranged Acute Leukemia
Nanfang Hospital, Southern Medical University
 2018-07 PHASE2; PHASE3
NCT04087967 UNKNOWN
Acute Myeloid Leukemia; Induction Chemotherapy
The First Affiliated Hospital of Soochow University
 2019-04-01 PHASE3
NCT04083911 UNKNOWN
Acute Myeloid Leukemia; Induction Chemotherapy
The First Affiliated Hospital of Soochow University
 2019-04-01 PHASE3
NCT03530085 UNKNOWN
Acute Myeloid Leukemia; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning; Elderly
Nanfang Hospital, Southern Medical University
 2018-06-15 PHASE2; PHASE3
NCT04013880 WITHDRAWN
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
Vanderbilt-Ingram Cancer Center
 2019-08-27 PHASE1; PHASE2
NCT02257138 COMPLETED
Blasts More Than 20 Percent of Bone Marrow Nucleated Cells; Blasts More Than 20 Percent of Peripheral Blood White Cells; Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2015-02-12 PHASE1; PHASE2
NCT02650986 ACTIVE_NOT_RECRUITING
Advanced Fallopian Tube Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Melanoma; Advanced Ovarian Carcinoma; Advanced Primary Peritoneal Carcinoma; Advanced Synovial Sarcoma; Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Metastatic Fallopian Tube Carcinoma; Metastatic Melanoma; Metastatic Ovarian Carcinoma; Metastatic Primary Peritoneal Carcinoma; Metastatic Synovial Sarcoma; Pathologic Stage III Cutaneous Melanoma AJCC v8; Pathologic Stage IIIA Cutaneous Melanoma AJCC v8; Pathologic Stage IIIB Cutaneous Melanoma AJCC v8; Pathologic Stage IIIC Cutaneous Melanoma AJCC v8; Pathologic Stage IIID Cutaneous Melanoma AJCC v8; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Platinum-Resistant Fallopian Tube Carcinoma; Platinum-Resistant Ovarian Carcinoma; Platinum-Resistant Primary Peritoneal Carcinoma; Stage III Fallopian Tube Cancer AJCC v8; Stage III Ovarian Cancer AJCC v8; Stage III Primary Peritoneal Cancer AJCC v8; Stage IIIA Fallopian Tube Cancer AJCC v8; Stage IIIA Ovarian Cancer AJCC v8; Stage IIIA Primary Peritoneal Cancer AJCC v8; Stage IIIA1 Fallopian Tube Cancer AJCC v8; Stage IIIA1 Ovarian Cancer AJCC v8; Stage IIIA2 Fallopian Tube Cancer AJCC v8; Stage IIIA2 Ovarian Cancer AJCC v8; Stage IIIB Fallopian Tube Cancer AJCC v8; Stage IIIB Ovarian Cancer AJCC v8; Stage IIIB Primary Peritoneal Cancer AJCC v8; Stage IIIC Fallopian Tube Cancer AJCC v8; Stage IIIC Ovarian Cancer AJCC v8; Stage IIIC Primary Peritoneal Cancer AJCC v8; Stage IV Fallopian Tube Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Primary Peritoneal Cancer AJCC v8; Stage IVA Fallopian Tube Cancer AJCC v8; Stage IVA Ovarian Cancer AJCC v8; Stage IVA Primary Peritoneal Cancer AJCC v8; Stage IVB Fallopian Tube Cancer AJCC v8; Stage IVB Ovarian Cancer AJCC v8; Stage IVB Primary Peritoneal Cancer AJCC v8; Unresectable Melanoma; Unresectable Ovarian Carcinoma; Unresectable Synovial Sarcoma
Roswell Park Cancer Institute
 2017-07-14 PHASE1; PHASE2
NCT02085408 COMPLETED
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
ECOG-ACRIN Cancer Research Group
 2011-02-04 PHASE3
NCT03063203 TERMINATED
Acute Myeloid Leukemia; Acute Myeloid Leukemia, Relapsed, Adult
Washington University School of Medicine
 2017-07-14 PHASE2
NCT02272478 UNKNOWN
Acute Myeloid Leukaemia; Myelodysplastic Syndrome
Cardiff University
 2014-10-30 PHASE2; PHASE3
NCT01893320 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2013-07-18 PHASE1; PHASE2
NCT03752138 WITHDRAWN
Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2019-03-31 PHASE1
NCT04353479 UNKNOWN
Acute Myeloid Leukemia
Shanghai Jiao Tong University School of Medicine
 2020-04-25 PHASE2
NCT03985007 COMPLETED
Acute Myeloid Leukemia, Relapsed, Adult
The First Affiliated Hospital of Soochow University
 2018-01-01 PHASE2
NCT04026269 UNKNOWN
Hodgkin Lymphoma
Han weidong
 2019-07-30 PHASE1; PHASE2
NCT02446145 TERMINATED
Acute Myeloid Leukemia
Technische Universität Dresden
 2015-05 PHASE2
NCT03663751 COMPLETED
Response Rate
Shanghai Jiao Tong University School of Medicine
 2018-07-01 PHASE2
NCT04611711 UNKNOWN
Patients With Digestive System Tumors Resistant to PD-1 Inhibitors
Peking University
 2020-11-01 PHASE1; PHASE2
NCT03252457 UNKNOWN
Purpura, Thrombocytopenic, Idiopathic; Immune Thrombocytopenia
Shandong University
 2018-09-01 PHASE3
NCT03701451 UNKNOWN
Nasopharyngeal Carcinoma
Wei Jiang
 2018-02-28 PHASE1; PHASE2
NCT04493099 WITHDRAWN
Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
M.D. Anderson Cancer Center
 2020-10 PHASE1; PHASE2
NCT02441803 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2015-09-14 PHASE2
NCT03535753 UNKNOWN
NHL
Beijing Immunochina Medical Science & Technology Co., Ltd.
 2017-09-01 PHASE1
NCT03256071 UNKNOWN
Acute Myeloid Leukemia; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning
The First Affiliated Hospital of Soochow University
 2017-09 PHASE2; PHASE3
NCT03263936 COMPLETED
Acute Myelogenous Leukemia
Therapeutic Advances in Childhood Leukemia Consortium
 2017-07-11 PHASE1
NCT02564536 WITHDRAWN
Chronic Myelomonocytic Leukemia; Juvenile Myelomonocytic Leukemia; Atypical Chronic Myeloid Leukemia; Myeloproliferative Neoplasm; Myelodysplastic Syndromes; Myelofibrosis
Washington University School of Medicine
 2017-06 PHASE1
NCT01211457 UNKNOWN
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Cyclacel Pharmaceuticals, Inc.
 2010-06-17 PHASE1; PHASE2
NCT04051996 TERMINATED
ACUTE MYELOID LEUKEMIA
Yale University
 2019-12-06 PHASE2
NCT04277442 COMPLETED
Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2020-03-11 PHASE1
NCT04076137 UNKNOWN
Malignant Solid Tumor
Benhealth Biopharmaceutical (Shenzhen) Co., Ltd.
 2019-05-01 EARLY_PHASE1
NCT03017131 ACTIVE_NOT_RECRUITING
Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma
Roswell Park Cancer Institute
 2017-12-08 PHASE1
NCT03358719 COMPLETED
Acute Myeloid Leukemia; Blasts 30 Percent or Less of Bone Marrow Nucleated Cells; Chronic Myelomonocytic Leukemia; High Risk Myelodysplastic Syndrome; Myelodysplastic Syndrome; Refractory Anemia
Roswell Park Cancer Institute
 2018-03-27 PHASE1
NCT02920008 COMPLETED
Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc.
 2017-03-16 PHASE3
NCT01720225 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2012-11-06 PHASE2
NCT02878785 COMPLETED
Acute Myeloid Leukemia
University of Maryland, Baltimore
 2016-08 PHASE1; PHASE2
NCT03453255 UNKNOWN
Chemotherapy
Chinese PLA General Hospital
 2018-01-01 PHASE1; PHASE2
NCT03913312 UNKNOWN
Acute Myeloid Leukemia
Ruijin Hospital
 2018-09-01 PHASE1; PHASE2
NCT03558412 UNKNOWN
T-lymphoblastic Lymphoma
Mingzhi Zhang
 2018-06-01 PHASE4
NCT04086238 COMPLETED
Healthy
EpiDestiny, Inc.
 2019-10-08 PHASE1
NCT03381781 UNKNOWN
Acute Myeloid Leukemia; P53 Mutation
Li Junmin
 2018-03 PHASE2
NCT02744742 COMPLETED
Myelodysplastic Syndrome; Allogeneic Hematopoietic Stem Cell Transplantation; Conditioning
Nanfang Hospital, Southern Medical University
 2016-04-18 PHASE2; PHASE3
NCT02959164 COMPLETED
Pancreatic Ductal Adenocarcinoma; Sarcoma
Mohammed Milhem
 2016-12-05 PHASE1
NCT01498445 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2012-06-12 PHASE1; PHASE2
NCT03356080 UNKNOWN
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Shanghai Tong Ren Hospital
 2017-07-07 PHASE2
NCT02664181 COMPLETED
Lung Cancer; Non-small Cell Lung Cancer
Case Comprehensive Cancer Center
 2017-06-06 PHASE2
NCT02281084 COMPLETED
Myelodysplastic Syndromes
Celgene
 2015-07-06 PHASE2
NCT03813186 COMPLETED
Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc.
 2018-11-08 PHASE1
NCT03579082 UNKNOWN
Diffuse Large B Cell Lymphoma
Mingzhi Zhang
 2018-06-01 PHASE4
NCT03395873 TERMINATED
Acute Myeloid Leukemia
Milton S. Hershey Medical Center
 2018-01-29 PHASE1
NCT01786343 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2013-02-05 PHASE2
NCT03828084 COMPLETED
Healthy
EpiDestiny, Inc.
 2019-04-03 PHASE1
NCT02252107 COMPLETED
Acute Myeloid Leukemia (AML)
Radboud University Medical Center
 2014-10 PHASE2
NCT02951728 UNKNOWN
Diffuse Large B Cell Lymphoma
Ruijin Hospital
 2016-10 PHASE1; PHASE2
NCT02487563 COMPLETED
Thrombocytopenia; Hematologic Diseases
The First Affiliated Hospital of Soochow University
 2015-10 PHASE3
NCT02996474 COMPLETED
Relapsed Acute Myeloid Leukemia
National Heart, Lung, and Blood Institute (NHLBI)
 2016-12-16 PHASE1; PHASE2
NCT03146871 TERMINATED
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Previously Treated Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes; Recurrent Adult Acute Myeloid Leukemia
University of Southern California
 2017-04-20 PHASE2
NCT03346642 UNKNOWN
Primary Mediastinal Large B-cell Lymphoma
Chinese PLA General Hospital
 2017-05-01 PHASE1; PHASE2
NCT02779569 UNKNOWN
Myelodysplastic Syndromes (MDS)
The First Affiliated Hospital with Nanjing Medical University
 2016-03
NCT03113071 TERMINATED
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Fox Chase Cancer Center
 2017-06-02 PHASE1; PHASE2
NCT02010645 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2014-03 PHASE2
NCT03045510 UNKNOWN
Myelodysplastic Syndromes
Shandong University
 2016-12-01 PHASE2
NCT02985372 UNKNOWN
Acute Myeloid Leukemia, Adult
Chunyan Ji
 2016-12 PHASE3
NCT02802267 UNKNOWN
Acute Myelogenous Leukemia
Hybrigenics Corporation
 2016-06 PHASE2
NCT02921061 COMPLETED
Mixed Phenotype Acute Leukemia; Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Myeloid Leukemia; Recurrent High Risk Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory High Risk Myelodysplastic Syndrome; Untreated Adult Acute Myeloid Leukemia
Fred Hutchinson Cancer Center
 2016-11-17 PHASE1; PHASE2
NCT01593670 COMPLETED
Myelodysplastic Syndrome
Masonic Cancer Center, University of Minnesota
 2013-03 PHASE2
NCT01241500 COMPLETED
Myelodysplastic Syndromes; MDS; RAEB; Chronic Myelomonocytic Leukemia
Traws Pharma, Inc.
 2010-11 PHASE3
NCT02343939 TERMINATED
Acute Myeloid Leukemia
Gilead Sciences
 2015-07-01 PHASE1; PHASE2
NCT02076191 COMPLETED
Myeloproliferative Neoplasms
John Mascarenhas
 2014-02 PHASE1; PHASE2
NCT02323607 COMPLETED
Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Bhavana Bhatnagar
 2016-01-12 PHASE1
NCT02190695 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia
Fox Chase Cancer Center
 2013-04-01 PHASE2
NCT02103478 COMPLETED
Myelodysplastic Syndrome; MDS
Astex Pharmaceuticals, Inc.
 2014-10-28 PHASE1; PHASE2
NCT02662647 COMPLETED
AML
Chinese PLA General Hospital
 2015-04 PHASE2
NCT01876641 TERMINATED
Metastatic Melanoma; Melanoma; BRAF-mutated Metastatic Melanoma; V600EBRAF-mutated Metastatic Melanoma
Mohammed M Milhem
 2013-10 PHASE1
NCT01685515 COMPLETED
Sickle Cell Disease
Yogen Saunthararajah
 2012-08 PHASE1
NCT02348489 COMPLETED
Leukemia, Myeloid, Acute
Astex Pharmaceuticals, Inc.
 2015-03-19 PHASE3
NCT02723435 WITHDRAWN
Acute Myeloid Leukemia With Gene Mutations; Adult Acute Myeloid Leukemia in Remission
Stanford University
 PHASE2
NCT03377725 WITHDRAWN
Myelodysplastic Syndromes; P53 Mutation
Li Junmin
 2018-03-20 PHASE3
NCT03282825 UNKNOWN
Advanced Breast Cancer
Dong Wha Pharmaceutical Co. Ltd.
 2017-03-28 PHASE1
NCT02472145 COMPLETED
Leukemia, Myeloid, Acute
Janssen Research & Development, LLC
 2015-08-04 PHASE2; PHASE3
NCT02846935 COMPLETED
T-cell Lymphoma; Aggressive B-cell Lymphoma; Non-Hodgkin's Lymphomas; Indolent B-cell Lymphoma
Yogen Saunthararajah
 2017-04-25 EARLY_PHASE1
NCT01794702 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2013-02-20 PHASE1; PHASE2
NCT01882660 TERMINATED
Colon Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2013-07
NCT02316964 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
Sumithira Vasu
 2015-04-21 PHASE1
NCT02954653 TERMINATED
Acute Myeloid Leukemia
Pfizer
 2016-11-28 PHASE1
NCT02685228 UNKNOWN
Pancreatic Cancer
The First Hospital of Jilin University
 2016-03
NCT02847000 COMPLETED
Metastatic Pancreatic Adenocarcinoma
Yogen Saunthararajah
 2016-12-20 EARLY_PHASE1
NCT02499861 COMPLETED
Cancer
St. Justine's Hospital
 2015-07 PHASE1; PHASE2
NCT02785900 TERMINATED
Acute Myeloid Leukemia
Seagen Inc.
 2016-05 PHASE3
NCT01568333 COMPLETED
Immune Thrombocytopenia
Shandong University
 2015-08 PHASE2
NCT01853228 TERMINATED
Acute Myeloid Leukemia
Janssen Research & Development, LLC
 2013-10-22 PHASE1; PHASE2
NCT01707004 COMPLETED
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
University of Wisconsin, Madison
 2013-05-16 PHASE2
NCT01928537 COMPLETED
Myelodysplastic Syndromes; Refractory Anemia With Excess Blasts; Chronic Myelomonocytic Leukemia; Cytopenia
Traws Pharma, Inc.
 2013-08 PHASE3
NCT01687400 COMPLETED
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Washington University School of Medicine
 2013-02-12 PHASE2
NCT02141477 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2015-05-06 PHASE1
NCT02412475 TERMINATED
Leukemia, Acute Myeloid
Michael Burke
 2015-02-21 PHASE1
NCT02469415 TERMINATED
Leukemia
M.D. Anderson Cancer Center
 2015-09-30 PHASE2
NCT01758367 UNKNOWN
Recurrent Adult Acute Myeloid Leukemia
Chinese PLA General Hospital
 2012-12 PHASE1; PHASE2
NCT02839694 WITHDRAWN
Neoplasm Metastasis; Sarcoma; Neoplasms, Germ Cell and Embryonal; Melanoma
National Cancer Institute (NCI)
 2016-07-07 PHASE1
NCT02634827 TERMINATED
Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Gene Mutations; FLT3 Tyrosine Kinase Domain Point Mutation; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Mayo Clinic
 2015-12-30 PHASE2
NCT02121418 COMPLETED
Chronic Myelomonocytic Leukemia-2; Myelodysplastic Syndrome; Myeloproliferative Neoplasm; Untreated Adult Acute Myeloid Leukemia
University of Washington
 2014-06
NCT01546038 COMPLETED
Acute Myeloid Leukemia
Pfizer
 2012-06-27 PHASE2
NCT02129101 COMPLETED
Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndrome; Essential Thrombocythemia; Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasm; Polycythemia Vera; Previously Treated Myelodysplastic Syndrome; Primary Myelofibrosis; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Mayo Clinic
 2014-05 PHASE1
NCT01352650 COMPLETED
Acute Myeloid Leukemia
Weill Medical College of Cornell University
 2011-06-17 PHASE1
NCT01303796 COMPLETED
Acute Myeloid Leukemia
Cyclacel Pharmaceuticals, Inc.
 2011-10-01 PHASE3
NCT01799083 UNKNOWN
Solid Tumors; B Cell Lymphoma
Han weidong
 2012-12 PHASE1; PHASE2
NCT02316028 COMPLETED
Liver Metastasis; Colorectal Cancer
Universitair Ziekenhuis Brussel
 2014-03 PHASE1; PHASE2
NCT02093403 COMPLETED
Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Bhavana Bhatnagar
 2014-03 PHASE1
NCT02264873 COMPLETED
Leukemia, Lymphoblastic, Acute; Leukemia, Myeloid Acute; Hematopoetic Myelodysplasia
University of Florida
 2014-10 PHASE1
NCT01241162 COMPLETED
Neuroblastoma; Ewings Sarcoma; Osteogenic Sarcoma; Rhabdomyosarcoma; Synovial Sarcoma
University of Louisville
 2010-08 PHASE1
NCT01729845 COMPLETED
Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Myeloid Leukemia
Fred Hutchinson Cancer Center
 2012-12-20 PHASE1; PHASE2
NCT01846624 TERMINATED
Acute Myeloid Leukemia (AML) With Multilineage Dysplasia Following Myelodysplastic Syndrome, in Adults; AML (Adult) With 11q23 (MLL) Abnormalities; AML (Adult) With Del (5q); AML (Adult) With Inv (16) (p13; q22); AML (Adult) With t (16;16) (p13; q22); AML (Adult) With t (8; 21) (q22; q22); Secondary AML (Adult); Untreated AML (Adult)
David Iberri
 2013-06 PHASE2
NCT02332889 TERMINATED
Gliomas; Medulloblastoma; Neuroectodermal Tumors, Primitive
University of Louisville
 2015-04 PHASE1; PHASE2
NCT01420926 COMPLETED
Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Therapy-Related Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2011-11-16 PHASE2
NCT01627041 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Adult Acute Basophilic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Alkylating Agent-Related Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2011-09-16 PHASE2
NCT02532010 TERMINATED
Acute Myeloid Leukemia (AML)
Weill Medical College of Cornell University
 2015-06-15 PHASE2
NCT02197676 COMPLETED
MDS
Groupe Francophone des Myelodysplasies
 2014-08-04 PHASE2
NCT02234037 TERMINATED
Leukemia
Emory University
 2013-11 PHASE1
NCT01375608 COMPLETED
Neutropenia; Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2011-06 PHASE2
NCT02013102 UNKNOWN
Myelodysplastic Syndrome
Cttq
 2013-03 PHASE4
NCT01861314 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Acute Myeloid Leukemia Post Cytotoxic Therapy; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2013-07-03 PHASE1
NCT02029417 TERMINATED
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Roswell Park Cancer Institute
 2014-07 PHASE2
NCT01829503 COMPLETED
Acute Myeloid Leukemia
Annie Im, M.D.
 2013-02 PHASE2
NCT01483690 TERMINATED
Acute Lymphoblastic Leukemia; Precursor B-Cell Lymphoblastic Leukemia; Precursor T-Cell Lymphoblastic Leukemia
Therapeutic Advances in Childhood Leukemia Consortium
 2011-12 PHASE1; PHASE2
NCT01834248 COMPLETED
Acute Myeloid Leukemia; Alkylating Agent-Related Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Refractory Anemia With Excess Blasts in Transformation
Roswell Park Cancer Institute
 2013-07-30 PHASE1
NCT00903760 COMPLETED
Myelodysplastic Syndrome
M.D. Anderson Cancer Center
 2010-01 PHASE2
NCT00414310 COMPLETED
Myelodysplastic Syndrome; Acute Myelogenous Leukemia
M.D. Anderson Cancer Center
 2006-12 PHASE2
NCT00715793 COMPLETED
Malignant Melanoma
Hussein Tawbi
 2008-06 PHASE1; PHASE2
NCT00791271 TERMINATED
Melanoma
M.D. Anderson Cancer Center
 2008-09-02 PHASE1
NCT01690507 COMPLETED
MDS; AML
Chinese PLA General Hospital
 2012-11 PHASE1; PHASE2
NCT01628471 COMPLETED
Non Small Cell Lung Cancer
Uman Pharma
 2012-11 PHASE1; PHASE2
NCT01993641 COMPLETED
Myelodysplastic Syndrome; MDS
Helsinn Healthcare SA
 2013-12 PHASE2
NCT01798901 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Alison Walker
 2013-09-17 PHASE1
NCT00867672 COMPLETED
Acute Myeloid Leukemia
University Hospital Freiburg
 2011-08 PHASE2
NCT02003573 TERMINATED
Leukemia, Myeloid, Acute
Boehringer Ingelheim
 2014-01-29 PHASE1
NCT00778375 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome
M.D. Anderson Cancer Center
 2008-10 PHASE2
NCT02084563 COMPLETED
Acute Myeloid Leukemia; Myeloproliferative Neoplasms; Myelodysplastic Syndromes; Myeloproliferative/Myelodysplastic Neoplasm
Hospital Israelita Albert Einstein
 2012-10 PHASE2
NCT00925132 TERMINATED
Metastatic Melanoma
University of Iowa
 2009-12 PHASE1; PHASE2
NCT00349596 COMPLETED
Acute Lymphocytic Leukemia
M.D. Anderson Cancer Center
 2006-07 PHASE1
NCT01149408 COMPLETED
Acute Myeloid Leukemia; AML
University of Utah
 2011-02 PHASE1
NCT01277484 UNKNOWN
Myelodysplastic Syndrome; Acute Myeloid Leukemia
Seoul St. Mary's Hospital
 2011-01 PHASE1
NCT01633099 UNKNOWN
Untreated Adult Acute Myeloid Leukemia; Effect of Drugs; Drug Safety
Jianxiang Wang
 2012-05 PHASE3
NCT00986804 COMPLETED
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Washington University School of Medicine
 2009-12 PHASE1
NCT00085293 COMPLETED
Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer
National Cancer Institute (NCI)
 2004-05 PHASE2
NCT01194908 TERMINATED
Breast Cancer; Breast Tumors; Breast Neoplasms
Emory University
 2010-07 PHASE1; PHASE2
NCT01455506 COMPLETED
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Hackensack Meridian Health
 2009-05 PHASE1
NCT01809392 UNKNOWN
Acute Myelocytic Leukemia; Myelodysplastic Syndromes
The First Affiliated Hospital of Soochow University
 2013-01 PHASE2; PHASE3
NCT01674985 COMPLETED
Myelodysplastic Syndromes
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
 2009-09 PHASE1; PHASE2
NCT01417767 UNKNOWN
Myelodysplastic Syndromes
Xiao Li
 2011-09 PHASE2; PHASE3
NCT01333449 TERMINATED
Myelodysplastic Syndrome
Singapore General Hospital
 2010-07 PHASE2
NCT01177540 TERMINATED
Pediatric Acute Myelogenous Leukemia (AML)
Eisai Inc.
 2011-03-03 PHASE2
NCT01607645 TERMINATED
Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts
Fred Hutchinson Cancer Center
 2012-07 PHASE2
NCT00691938 COMPLETED
Leukemia, Myeloid, Acute; Myelodysplastic Syndromes
Washington University School of Medicine
 2008-06 PHASE1; PHASE2
NCT01567059 COMPLETED
Acute Myeloid Leukemia With Multilineage Dysplasia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Untreated Adult Acute Myeloid Leukemia
Fred Hutchinson Cancer Center
 2012-05 PHASE2
NCT01813838 TERMINATED
SMD
Groupe Francophone des Myelodysplasies
 2013-06 PHASE1; PHASE2
NCT01001143 COMPLETED
Leukemia, Myeloid, Acute
Washington University School of Medicine
 2010-05 PHASE1
NCT01806116 UNKNOWN
Higher-risk Myelodysplastic Syndrome; Relapsed /Refractory Acute Myeloid Leukemia
The First Affiliated Hospital of Soochow University
 2009-09 PHASE4
NCT00084981 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
 2004-04 PHASE1
NCT00879385 COMPLETED
Colorectal Cancer
University of Utah
 2009-12 PHASE1
NCT00882206 TERMINATED
Leukemia; Lymphoma
Masonic Cancer Center, University of Minnesota
 2009-04 PHASE2
NCT01130506 COMPLETED
Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2010-05-17 PHASE1
NCT01133886 UNKNOWN
Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome
King's College London
 2010-09 PHASE2
NCT00861874 COMPLETED
Acute Myeloid Leukemia
University of Rochester
 2010-01 PHASE1
NCT00968071 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
M.D. Anderson Cancer Center
 2008-02 PHASE2
NCT00828802 COMPLETED
Myelodysplastic Syndromes
Duke University
 2009-03 PHASE1
NCT00882102 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
M.D. Anderson Cancer Center
 2009-04 PHASE2
NCT00398983 COMPLETED
Acute Myelogenous Leukemia
M.D. Anderson Cancer Center
 2006-08 PHASE2; PHASE3
NCT00619099 COMPLETED
Myelodysplastic Syndrome
Eisai Inc.
 2008-05 PHASE2
NCT01165996 COMPLETED
Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Myelodysplastic Syndromes; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Ringed Sideroblasts; Refractory Cytopenia With Multilineage Dysplasia; Thrombocytopenia
Case Comprehensive Cancer Center
 2010-07 PHASE1; PHASE2
NCT01251627 COMPLETED
Chronic Myelomonocytic Leukemia
Fondazione Italiana Sindromi Mielodisplastiche-ETS
 2010-04 PHASE2
NCT01673217 COMPLETED
Recurrent Fallopian Tube Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Primary Peritoneal Cavity Cancer
Roswell Park Cancer Institute
 2009-04 PHASE1
NCT01130662 COMPLETED
Acute Myeloid Leukemia
University of Kansas
 2010-03 PHASE1
NCT00941109 COMPLETED
Myelodysplastic Syndrome
Eisai Inc.
 2009-12 PHASE1
NCT00943553 WITHDRAWN
Acute Myelogenous Leukemia (AML)
Eisai Inc.
 2010-06 PHASE2
NCT00477386 COMPLETED
Ovarian Cancer
Indiana University
 2007-07 PHASE1; PHASE2
NCT01751867 COMPLETED
Myelodysplastic Syndrome
Xian-Janssen Pharmaceutical Ltd.
 2009-08 PHASE3
NCT00079378 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2004-02 PHASE1
NCT00416598 COMPLETED
Acute Myeloid Leukemia; Acute Myeloid Leukemia With Myelodysplasia-Related Changes; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2006-11-15 PHASE2
NCT01011283 TERMINATED
Myelodysplastic Syndromes
Eisai Inc.
 2009-11 PHASE4
NCT00492401 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2007-05 PHASE2
NCT00796003 COMPLETED
Myelodysplastic Syndrome
Janssen Pharmaceutical K.K.
 2008-07 PHASE1
NCT00701298 TERMINATED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2009-04 PHASE1
NCT00744757 COMPLETED
Myelodysplastic Syndrome
Johnson & Johnson Taiwan Ltd
 2008-08 PHASE2
NCT00886457 TERMINATED
Cancer
Nevada Cancer Institute
 2009-04 PHASE1
NCT00049582 TERMINATED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; de Novo Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2002-09 PHASE1
NCT00661726 COMPLETED
Thalassemia
Carelon Research
 2008-01 PHASE2
NCT00621023 COMPLETED
Myelodysplastic Syndrome
Duke University
 2007-11 PHASE2
NCT00479232 COMPLETED
Leukemia, Myelocytic, Acute Myelodysplastic Syndromes; Myelodysplastic Syndromes
Merck Sharp & Dohme LLC
 2007-06 PHASE1
NCT00703300 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2008-06 PHASE1
NCT00740181 TERMINATED
Myelodysplasia; Leukemia
Brown University
 2008-08 PHASE2
NCT00671697 COMPLETED
Myelodysplastic Syndromes and Leukemia, Myeloid, Acute
Washington University School of Medicine
 2008-05 PHASE1
NCT00748527 TERMINATED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
Cancer Research UK
 2007-07 PHASE2
NCT00538876 COMPLETED
Acute Myeloid Leukemia
Weill Medical College of Cornell University
 2007-07 PHASE1
NCT00275080 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Secondary Acute Myeloid Leukemia; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2006-02 PHASE1
NCT00561912 TERMINATED
Renal Cell Carcinoma
M.D. Anderson Cancer Center
 2007-10 PHASE2
NCT00321711 COMPLETED
MDS; Myelodysplastic Syndromes; Thrombocytopenia
Amgen
 2006-10-01 PHASE2
NCT00357708 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Chronic Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Philadelphia Chromosome Negative Chronic Myelogenous Leukemia; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Relapsing Chronic Myelogenous Leukemia
National Cancer Institute (NCI)
 2006-06 PHASE1
NCT00260832 COMPLETED
Acute Myeloid Leukemia
Eisai Inc.
 2005-11 PHASE3
NCT00630994 TERMINATED
Chronic Myeloproliferative Disorders; Secondary Myelofibrosis
Mayo Clinic
 2008-03 PHASE2
NCT01098084 COMPLETED
Chronic Myelomonocytic Leukemia
Groupe Francophone des Myelodysplasies
 2008-11 PHASE2
NCT00067808 COMPLETED
Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia
M.D. Anderson Cancer Center
 2003-10 PHASE2
NCT00109824 COMPLETED
Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Mantle Cell Lymphoma
National Cancer Institute (NCI)
 2006-03 PHASE1
NCT00866073 COMPLETED
Acute Myeloid Leukemia
University Hospital Freiburg
 2003-04 PHASE2
NCT00113321 TERMINATED
Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia
M.D. Anderson Cancer Center
 2005-03 PHASE2
NCT00037817 COMPLETED
Advanced Esophageal Cancers; Primary Small Cell Lung Cancers; Non-Small-Cell Lung Carcinoma; Pleural Mesotheliomas; Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura
National Cancer Institute (NCI)
 2002-05-17 PHASE1
NCT00282399 TERMINATED
Myelodysplastic Syndrome
Eisai Inc.
 2006-10 PHASE1
NCT00030615 COMPLETED
Male Breast Cancer; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Melanoma; Stage III Melanoma; Stage IV Bladder Cancer; Stage IV Breast Cancer; Stage IV Melanoma; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2001-12 PHASE1
NCT00095784 ACTIVE_NOT_RECRUITING
Primary Myelofibrosis; Secondary Myelofibrosis
National Cancer Institute (NCI)
 2004-09-29 PHASE2
NCT00260065 COMPLETED
Myelodysplastic Syndrome
Eisai Inc.
 2005-05 PHASE2
NCT00043134 UNKNOWN
Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
European Organisation for Research and Treatment of Cancer - EORTC
 2002-05 PHASE3
NCT00089089 TERMINATED
Hematopoietic/Lymphoid Cancer; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2004-09 PHASE1
NCT00358644 COMPLETED
Acute Myeloid Leukemia
Eisai Inc.
 2005-03 PHASE2
NCT00075634 COMPLETED
Recurrent Neuroblastoma; Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2003-12 PHASE1
NCT00054431 COMPLETED
Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Childhood Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Relapsing Chronic Myelogenous Leukemia
National Cancer Institute (NCI)
 2003-01 PHASE2
NCT00075010 COMPLETED
Leukemia; Myelodysplastic Syndromes
M.D. Anderson Cancer Center
 2004-01-23 PHASE1; PHASE2
NCT00114257 COMPLETED
Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
National Cancer Institute (NCI)
 2005-05 PHASE1
NCT01378416 COMPLETED
Leukemia
Eisai Inc.
 2005-04 PHASE1
NCT00042796 TERMINATED
Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
National Cancer Institute (NCI)
 2002-12 PHASE1
NCT00760084 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
Eisai Inc.
 2005-07 PHASE2
NCT00042003 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2
NCT00003361 COMPLETED
Leukemia; Myelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center
 1998-04 PHASE2
NCT00002831 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 1995-08-01 PHASE1; PHASE2
NCT00043381 COMPLETED
Myelodysplastic Syndrome
Astex Pharmaceuticals, Inc.
 2001-04 PHASE3
NCT00002832 COMPLETED
Leukemia; Myelodysplastic Syndromes
M.D. Anderson Cancer Center
 1995-08 PHASE1; PHASE2
NCT00041990 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2
NCT00002980 COMPLETED
Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Precancerous Condition; Unspecified Adult Solid Tumor, Protocol Specific
California Cancer Consortium
 1997-05 PHASE1
NCT00019825 COMPLETED
Esophageal Cancer; Lung Cancer; Malignant Mesothelioma; Metastatic Cancer
National Cancer Institute (NCI)
 1999-10 PHASE1
NCT00042016 COMPLETED
Chronic Myelogenous Leukemia
Astex Pharmaceuticals, Inc.
 2002-07 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-09-03)

Check the Decitabine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Decitabine functions as a nucleoside analog that incorporates into DNA during replication and covalently binds DNA methyltransferases, thereby inhibiting catalytic DNA methylation and suppressing downstream gene silencing. This hypomethylation promotes reactivation of silenced tumor suppressor genes, leading to intra-S-phase cell cycle arrest and apoptosis that provides therapeutic efficacy in myelodysplastic syndromes and acute myeloid leukemia.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.