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Daraxonrasib (RMC-6236) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Daraxonrasib (RMC-6236)
  • Catalog Number: E1597
  • CAS Number: 2765081-21-6
  • IUPAC Name: Cyclopropanecarboxamide, N -[(2R ,14S ,18S )-1-ethyl-18,19,20,21- tetrahydro-2-[2-[(1S )-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3- pyridinyl]-25,25-dimethyl-15,22-dioxo-17H -5,3-([4,2]-endo -thiazolo propano[1,3]-endo -pyridazinomethanoxypropano)-1H -indol-14-yl]- 2-methyl-, (1S ,2S )

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS Classification:

  • Acute toxicity (Oral): Category 4
  • Skin irritation: Category 2

Signal Word: Warning

Pictogram: GHS07

Hazard Statements:

  • H302: Harmful if swallowed.
  • H315: Causes skin irritation.

Precautionary Statements:

  • Prevention: Wash skin thoroughly after handling. Do not eat, drink, or smoke when using this product. Wear protective gloves.
  • Response: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. IF ON SKIN: Wash with plenty of water. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash it before reuse.
  • Disposal: Dispose of contents/container to an approved waste disposal plant.

Other Hazards: None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance/Mixture: Substance

Components:

  • Chemical Name: RMC 6236
  • CAS-No.: 2765081-21-6
  • Concentration: >= 80 - <= 100%
  • Note: The actual concentration or concentration range is withheld as a trade secret. No chemical structural formula is provided in the source text.

4. FIRST AID MEASURES

  • General Advice: Show this safety data sheet to the doctor in attendance.
  • If Inhaled: Move to fresh air.
  • In Case of Skin Contact: Take off immediately all contaminated clothing. Rinse skin with water/shower.
  • In Case of Eye Contact: Rinse out with plenty of water. Remove contact lenses.
  • If Swallowed: Immediately make victim drink water (two glasses at most). Consult a physician.
  • Most Important Symptoms and Effects: The most important known symptoms and effects are described in the labelling (Section 2) and/or Section 11.
  • Protection of First-Aiders: Refer to Section 8 for personal protection.
  • Notes to Physician: N/A.

5. FIREFIGHTING MEASURES

  • Suitable Extinguishing Media: Water, Foam, Carbon dioxide (CO2), Dry powder.
  • Unsuitable Extinguishing Media: No limitations of extinguishing agents are given for this substance.
  • Specific Hazards: Combustible. Development of hazardous combustion gases or vapors is possible in the event of fire.
  • Hazardous Combustion Products: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides.
  • Specific Extinguishing Methods: N/A.
  • Further Information: Suppress gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
  • Special Protective Equipment: Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

6. ACCIDENTAL RELEASE MEASURES

  • Personal Precautions, Protective Equipment, and Emergency Procedures: Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, and consult an expert. For emergency responders, see Section 8.
  • Environmental Precautions: Do not let product enter drains.
  • Methods and Materials for Containment and Cleaning Up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions. Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

7. HANDLING AND STORAGE

  • Precautions for Safe Handling: For precautions, see Section 2.2.
  • Conditions for Safe Storage: Keep container tightly closed and dry.
  • Storage Class: 11, Combustible Solids.
  • Recommended Storage Temperature: -13 - 14 °F / -25 - -10 °C.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

  • Control Parameters: Contains no substances with occupational exposure limit values.
  • Engineering Measures: N/A.
  • Personal Protective Equipment:
    • Respiratory Protection: Required when dusts are generated. Recommended filter type: P2 (based on DIN EN 143, DIN 14387).
    • Hand Protection: Nitrile rubber gloves. Full and splash contact: 0.11 mm thickness, 480 min breakthrough time (e.g., KCL 741 Dermatril L).
    • Eye Protection: Safety glasses tested and approved under government standards such as NIOSH (US) or EN 166 (EU).
    • Skin and Body Protection: Protective clothing.
  • Hygiene Measures: Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with the substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

  • Appearance: powder
  • Color: N/A
  • Odor: N/A
  • Odor Threshold: N/A
  • pH: N/A
  • Melting Point: N/A
  • Boiling Point: N/A
  • Flash Point: Not applicable
  • Evaporation Rate: N/A
  • Flammability (solid, gas): N/A
  • Upper/Lower Explosion Limit: N/A
  • Vapor Pressure: N/A
  • Relative Vapor Density: N/A
  • Relative Density: N/A
  • Density: N/A
  • Solubility: Soluble in water (68 °F / 20 °C)
  • Partition Coefficient (n-octanol/water): N/A
  • Auto-ignition Temperature: N/A
  • Decomposition Temperature: N/A
  • Viscosity: N/A
  • Explosive Properties: Not classified as explosive.
  • Oxidizing Properties: None
  • Molecular Weight: 811 g/mol
  • Particle Size: N/A

10. STABILITY AND REACTIVITY

  • Reactivity: Flammable organic substance; in fine distribution, a dust explosion potential may generally be assumed when whirled up.
  • Chemical Stability: The product is chemically stable under standard ambient conditions (room temperature).
  • Possibility of Hazardous Reactions: Violent reactions possible with strong oxidizing agents.
  • Conditions to Avoid: No information available.
  • Incompatible Materials: N/A.
  • Hazardous Decomposition Products: In the event of fire, see Section 5.

11. TOXICOLOGICAL INFORMATION

  • Acute Toxicity: Acute toxicity estimate (Oral) - 500.1 mg/kg (Expert judgement based on QSAR approach). Inhalation and Dermal data not available.
  • Skin Corrosion/Irritation: Causes skin irritation (Statement based on QSAR approach).
  • Serious Eye Damage/Irritation: N/A.
  • Respiratory or Skin Sensitization: N/A.
  • Germ Cell Mutagenicity: N/A.
  • Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as a probable, possible, or confirmed human carcinogen by IARC, NTP, or OSHA.
  • Reproductive Toxicity: N/A.
  • STOT - Single Exposure: N/A.
  • STOT - Repeated Exposure: N/A.
  • Aspiration Hazard: N/A.
  • Additional Information: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

  • Ecotoxicity: N/A.
  • Persistence and Degradability: N/A.
  • Bioaccumulative Potential: N/A.
  • Mobility in Soil: N/A.
  • Other Adverse Effects: This product neither contains, nor was manufactured with a Class I or Class II ODS as defined by the U.S. Clean Air Act Section 602.

13. DISPOSAL CONSIDERATIONS

  • Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers. Do not mix with other waste. Handle uncleaned containers like the product itself.

14. TRANSPORT INFORMATION

  • DOT (49 CFR): Not regulated as a dangerous good.
  • IATA: Not regulated as a dangerous good.
  • IMDG: Not regulated as a dangerous good.
  • Transport in Bulk: Not applicable for product as supplied.
  • Special Precautions: Not classified as dangerous in the meaning of transport regulations. Poison Inhalation Hazard: No.

15. REGULATORY INFORMATION

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.

SARA 313
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

Clean Air Act
This product neither contains, nor was manufactured with a Class I or Class II ODS as defined by the U.S. Clean Air Act Section 602 (40 CFR 82, Subpt. A, App.A + B).
This product does not contain any hazardous air pollutants (HAP), as defined by the U.S. Clean Air Act Section 112 (40 CFR 61).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 112(r) for Accidental Release Prevention (40 CFR 68.130, Subpart F).
This product does not contain any chemicals listed under the U.S. Clean Air Act Section 111 SOCMI Intermediate or Final VOC's (40 CFR 60.489).

Clean Water Act
This product does not contain any Hazardous Substances listed under the U.S. CleanWater Act, Section 311, Table 116.4A.
This product does not contain any Hazardous Chemicals listed under the U.S. CleanWater Act, Section 311, Table 117.3.
This product does not contain any toxic pollutants listed under the U.S. Clean Water Act Section 307
This product does not contain any priority pollutants related to the U.S. Clean Water Act

US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.

Maine Chemicals of High Concern
Product does not contain any listed chemicals

Vermont Chemicals of High Concern
Product does not contain any listed chemicals

Washington Chemicals of High Concern
Product does not contain any listed chemicals

The components of this product are reported in the following inventories:
TSCA : Product contains substance(s) not listed on TSCA inventory.

TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.

16. OTHER INFORMATION

Revision Date: 2026/07/03
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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