Dabrafenib (GSK2118436): Selectivity & Specificity
Dabrafenib (GSK2118436) is a potent inhibitor of Unaltered EGFR (0.4 nM), Altered EGFR (V774M) (690 nM), BRAF, RIPK3. Dabrafenib (GSK2118436) exhibits the greatest inhibitory potency toward Unaltered EGFR (IC50 = 0.4 nM).