Cell-free Assays (IC50/Ki) for Dabrafenib (GSK2118436)

Key TargetIC50 (Cell-free)DescriptionReference
Unaltered EGFR 0.0004 µM Data from PubChem database PMC11199933
Altered EGFR (V774M) 0.69 µM Data from PubChem database PMC11199933

Cell-based Assay (IC50) for Dabrafenib (GSK2118436)

Cell TypeIC50 (Cell-based)DescriptionReference
A375 melanoma cells 0.7 ± 0.4 µM XTT cell viability assay, CalcuSyn software Download PDF
RPMI 7951 melanoma cells 0.9 ± 0.5 µM XTT cell viability assay, CalcuSyn software Download PDF
A549 40.17 µM RSV-GFP inhibition measured by fluorescence intensity; Cell viability determined using CyQUANT MTT Cell Proliferation Assay Kit. PMC12720153
ME4686DR ≥ 1µM Cell Titer-Glo Luminescent Cell Viability assay Download PDF
ME4686 4.11nM Cell Titer-Glo Luminescent Cell Viability assay Download PDF
Check the Dabrafenib (GSK2118436) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

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