CAS No. 1195765-45-7
Batch:
Purity:99.99
Chemical Structure
Check the
Dabrafenib (GSK2118436)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide | |
|---|---|---|
| CAS Number | 1195765-45-7 | |
| Molecular Formula |
C23H20F3N5O2S2 |
|
| Molecular Weight (MW) | 519.56 | |
| SMILES | CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F | |
| InChIKey | BFSMGDJOXZAERB-UHFFFAOYSA-N |
Dabrafenib (GSK2118436) is a selective inhibitor of mutant BRAF V600E (IC50 0.7 nM), displaying 7-fold less potency against wild-type BRAF and 9-fold less potency against C-RAF. By inhibiting oncogenic BRAF kinase activity, it suppresses downstream MAPK/ERK pathway signaling, thereby decreasing cancer cell proliferation and inducing cell cycle arrest and apoptosis in BRAF-mutant melanoma models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(192.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(192.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(192.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(192.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(192.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Dabrafenib (GSK2118436) Mechanism of Action: BRAF Inhibition in Melanocyte Research
- Dabrafenib (GSK2118436) Clinical Trials
- Dabrafenib (GSK2118436): Selectivity & Specificity
- Dabrafenib (GSK2118436) Working Concentration | Cell Culture | Treatment
- Dabrafenib (GSK2118436) Solubility in DMSO
- Dabrafenib (GSK2118436) Stock Solution
- Dabrafenib (GSK2118436) Storage
- Dabrafenib (GSK2118436) Stability
- Dabrafenib (GSK2118436) Combination Database
- Dabrafenib (GSK2118436) Molecular Weight
- Dabrafenib (GSK2118436) SMILES
- Dabrafenib (GSK2118436) Chemical Structure (2D and 3D)
- Dabrafenib (GSK2118436) IC50 for Cell-based and Cell-free Assays
- Dabrafenib (GSK2118436) Sigma (AMBH47A8ED73)? Try a better option.
- Dabrafenib (GSK2118436) MedChemExpress (HY-14660)? Try a better option.
- Dabrafenib (GSK2118436) Cayman (16989)? Try a better option.
- Dabrafenib (GSK2118436) Abmole (M1988)? Try a better option.
- Dabrafenib (GSK2118436) Cell Signaling Technology (91942)? Try a better option.
- Dabrafenib (GSK2118436) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.