Creatine Clinical Trials

Size	Price	Qty
25mg	USD 147
1g	USD 970

Clinical Trials

Numerous clinical trials evaluate creatine across diverse physiological and therapeutic domains, investigating athletic and cognitive performance alongside conditions such as major depressive disorder, chronic obstructive pulmonary disease, myocardial ischemia, HIV, and C3 glomerulopathy. Spanning Early Phase 1 through Phase 4, these investigations are sponsored by academic medical centers, university hospitals, and government agencies. Recruitment statuses across these studies encompass completed, recruiting, not yet recruiting, and terminated trials.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07756060	NOT_YET_RECRUITING	Brain Injury; Traumatic Brain Injury; Stroke	Spaulding Rehabilitation Hospital	2026-10
NCT06018519	RECRUITING	Creatine Transporter Defect	Hospices Civils de Lyon	2023-03-13
NCT07463092	RECRUITING	Prostate Cancer; Sarcopenia	University of Sao Paulo	2026-05-01
NCT06112990	RECRUITING	Metastatic Prostate Cancer	University of Utah	2023-11-09	PHASE3
NCT07729930	RECRUITING	Cognition; Muscle Strength; Fatigue Symptom; Blood Pressure and Augmentation Index; Body Composition Changes; Sleep; Gastrointestinal Comfort; Quality of Life; Joint Pain; Inflammation Biomarkers; Bone Metabolism Biomarkers; Menopause Symptoms	Loughborough University	2026-05-01
NCT07310043	NOT_YET_RECRUITING	Neurocognitive Disorders; Postoperative Delirium	Massachusetts General Hospital	2026-09-01
NCT07372144	NOT_YET_RECRUITING	Breast Cancer	D'Or Institute for Research and Education	2026-08-01	PHASE3
NCT06395506	RECRUITING	Breast Cancer; Breast Cancer Female; Muscle Weakness	The University of Texas Medical Branch, Galveston	2024-10-29
NCT07177183	RECRUITING	Prolonged Mechanical Ventilation; Critical Illness	University Hospital Ostrava	2026-02-02
NCT06948149	RECRUITING	Creatine; Exercise; Mild Cognitive Impairment (MCI)	Western University, Canada	2026-01-01
NCT05895747	RECRUITING	Major Depressive Disorder	University of Utah	2023-09-28	PHASE2
NCT06208813	RECRUITING	Concussion, Brain	San Diego State University	2024-02-01
NCT06925880	RECRUITING	Sarcopenia in Elderly; Frailty at Older Adults; Functional Capacity; Creatine Supplementation; Arthroplasties, Knee Replacement; Physical Performance	Consorci Sanitari del Maresme	2025-06-10
NCT07625202	RECRUITING	Sarcopenia	University of Saskatchewan	2026-05-25
NCT07795853	NOT_YET_RECRUITING	Post-partum; Women	University of North Carolina, Chapel Hill	2026-09-08
NCT07593014	NOT_YET_RECRUITING	Heat Exposure; Exercise Performance; Hydration; Body Fluid Compartments; Creatine Supplementation; Placebo - Control; Plasma Volume	University of Windsor	2026-07-30
NCT07343999	NOT_YET_RECRUITING	Transthyretin Cardiac Amyloidosis	Universidad de Burgos	2026-06
NCT07472426	RECRUITING	Acute Kidney Injury; Exertional Heat Illness	University of Northern Iowa	2026-03-12
NCT06576466	RECRUITING	Stroke, Ischemic	Fundació d'investigació Sanitària de les Illes Balears	2024-09-27
NCT07275996	ACTIVE_NOT_RECRUITING	Frailty; Sarcopenia; Aging; Malnutrition Elderly	Universidad de Burgos	2026-03-10
NCT07756658	NOT_YET_RECRUITING	Tyrosol; Creatine; Endurance Performance; Cognition; Mood	Applied Science & Performance Institute	2026-08-17
NCT07029243	RECRUITING	Cirrhosis; Frailty; Sarcopenia	University of California, San Francisco	2026-04-15
NCT07579455	RECRUITING	Creatine Absorption in Healthy Adults	University of Oklahoma	2026-06
NCT07766395	RECRUITING	Lean Muscle Development; Muscular Endurance; Hormone-Related Wellness; Digestive Comfort; Dermatologic Health; Overall Wellness	Clean Nutraceuticals	2026-09
NCT07712653	NOT_YET_RECRUITING	Exercise Performance Recovery	California Polytechnic State University-San Luis Obispo	2026-07-15
NCT07285226	RECRUITING	Sarcopenia	Center for Health Sciences, Serbia	2025-12-01
NCT07666815	RECRUITING	Chronic Kidney Disease 5D	Pedro Julian Flores Moreno	2026-03-02	PHASE1; PHASE2
NCT06992414	NOT_YET_RECRUITING	Long COVID Fatigue	University of Calgary	2025-07-02
NCT05856916	SUSPENDED	Presbyphonia	NYU Langone Health	2026-05-01
NCT06675708	COMPLETED	Fibromyalgia	Camilo Jose Cela University	2025-02-12
NCT06920667	NOT_YET_RECRUITING	Type 2 Diabetes Mellitus	Héctor Iván Saldívar Cerón	2025-06-01
NCT07213063	RECRUITING	Down Syndrome (DS); Supplementation	Universidad de Burgos	2025-09-15
NCT06503016	RECRUITING	Hypotension; Consciousness, Level Altered; Airway Disease; Respiratory Failure; Tachypnea; Bradypnea; Tachycardia; Bradycardia; Cardiac Failure; Cardiac Arrest	Università Vita-Salute San Raffaele	2024-10-08	PHASE3
NCT07475676	NOT_YET_RECRUITING	Performance Enhancement	St. Mary's University, Twickenham	2026-03-01
NCT07451496	RECRUITING	Ageing	National University of Singapore	2025-09-29
NCT05823740	COMPLETED	Cancer; Malignant Neoplasm	UNC Lineberger Comprehensive Cancer Center	2023-05-01
NCT07534293	COMPLETED	Creatine Supplementation; Exercise Ergogenics	Universitas Negeri Malang	2026-02-07
NCT07735988	COMPLETED	Healthy Men Doing Resistance Training	Yakup Enes Çam	2026-01-05
NCT05431413	UNKNOWN	Depression	Nanfang Hospital, Southern Medical University	2020-01-07	PHASE2
NCT07225335	COMPLETED	Creatine Absorption in Healthy Adults	TSI Group LTD	2025-11-05
NCT07027800	COMPLETED	Perimenopause	University of North Carolina, Chapel Hill	2025-06-02
NCT04218786	Withdrawn	Myocardium; Injury\|Myocardial Infarction\|Myocardial Ischemia	Shifa Tameer-e-Millat University\|Rawalpindi Institute of Cardiology	2025-12	Phase 2
NCT02374112	ACTIVE_NOT_RECRUITING	Chronic Fatigue Syndrome	Center for Health Sciences, Serbia	2016-01
NCT07233707	ENROLLING_BY_INVITATION	Healthy	Harokopio University	2025-07-24
NCT06677359	RECRUITING	Functionality; Cognition; Strength Training Effects	Fundacion Miguel Servet	2024-11-30
NCT06420726	COMPLETED	Colorectal Cancer	University of South Carolina	2023-09-01
NCT06991426	NOT_YET_RECRUITING	Copd; Athletes	Federal University of São Paulo	2025-07	PHASE4
NCT05856500	UNKNOWN	Stage IV Gastric Cancer; Stage IIIA Gastric Cancer; Stage IIIB Gastric Cancer; Stage III Esophageal Cancer; Stage IV Esophageal Cancer	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	2023-06-01
NCT06883292	COMPLETED	Tyrosol; Creatine; Endurance Performance; Cognition	Applied Science & Performance Institute	2025-03-24
NCT06606704	RECRUITING	Aging	University of Regina	2024-08-20
NCT06495567	ACTIVE_NOT_RECRUITING	Homocystinuria	University of British Columbia	2024-08-19
NCT06606717	RECRUITING	Sarcopenia in Elderly	University of Regina	2024-08-18
NCT06489587	UNKNOWN	Exercise Performance	California Polytechnic State University-San Luis Obispo	2024-06-25
NCT05589064	RECRUITING	Brain Injury Traumatic Mild	Universite de Moncton	2022-10-01
NCT06594406	COMPLETED	Depression	Zhujiang Hospital	2024-10-10
NCT06660004	COMPLETED	Menopausal; Perimenopause	University of Novi Sad, Faculty of Sport and Physical Education	2024-11-15
NCT07548541	COMPLETED	Anaerobic Performance; Cognitive Performance; Healthy Volunteers	Inonu University	2025-04-01
NCT05681806	COMPLETED	Muscle Hypotrophy	Applied Science & Performance Institute	2023-02-23
NCT06937190	RECRUITING	Anaerobic Performance; Sports Nutrition; Exercise Recovery; Muscle Fatigue; Creatine Supplementation; Recreational Physical Activity; Female Athletes	Ankara Yildirim Beyazıt University	2025-04-01
NCT04498078	COMPLETED	Autism Spectrum Disorder	University of Novi Sad, Faculty of Sport and Physical Education	2022-01-15
NCT05878106	UNKNOWN	Breast Cancer; Supplementation; Resistance Training; Physical Performance; Quality of Life	University of Deusto	2024-04-08
NCT03597581	COMPLETED	Gastrointestinal Cancer; Gastrointestinal Neoplasms; Colorectal Cancer; Colorectal Neoplasms; Colorectal Carcinoma; Gastric Cancer; Gastric Neoplasm; KRAS Mutation-Related Tumors; CRC; Colorectal Cancer Metastatic	Inspirna, Inc.	2018-06-05	PHASE1
NCT06345612	COMPLETED	Type 1 Diabetes	Silesian Centre for Heart Diseases	2023-11-15
NCT03987217	COMPLETED	Fatigue; Metastatic Prostate Carcinoma; Sedentary Lifestyle; Stage IV Prostate Cancer AJCC (American Joint Committee on Cancer) v8; Stage IVA Prostate Cancer AJCC (American Joint Committee on Cancer) v8; Stage IVB Prostate Cancer AJCC (American Joint Committee on Cancer) v8	University of Utah	2019-06-17	EARLY_PHASE1
NCT05951439	COMPLETED	Aging; Sarcopenia; Nutrition, Healthy	Universidad de Burgos	2024-11-08
NCT06604793	RECRUITING	Improve Muscle Performance in Young Adults	University of Regina	2024-08-20
NCT06225570	Not yet recruiting	Acne Vulgaris	Medical University of South Carolina	2025-01	Early Phase 1
NCT06250556	UNKNOWN	Athletes	University of Sao Paulo	2024-02-10
NCT06438887	UNKNOWN	Strength; Muscle	University of Regina	2024-05-15
NCT05627479	Not yet recruiting	Femoral Shaft Fracture\|Tibial Shaft Fracture	NYU Langone Health	2024-12-01	Phase 2
NCT06644131	COMPLETED	Mild Traumatic Brain Injury; Concussion (Diagnosis)	University of Southern Denmark	2023-08-01
NCT05647811	Not yet recruiting	C3 Glomerulopathy	NovelMed Therapeutics	2024-11	Phase 1\|Phase 2
NCT05946772	Not yet recruiting	Takotsubo Cardiomyopathy	University Hospital Heidelberg\|German Centre of Cardiovascular Research (DZHK)\|Coordinating Centre for Clinical Studies (KKS) Heidelberg	2024-10	Phase 2
NCT05562232	UNKNOWN	Mild Traumatic Brain Injury; Concussion, Brain	Psychiatric Research Unit, Region Zealand, Denmark	2023-08-01
NCT06483321	COMPLETED	Deficiency; Diet	Universidad Francisco de Vitoria	2024-07-30
NCT07521059	COMPLETED	Safety of Short Term Creatine Hydrochloride Dosing	Vireo Systems, Inc.	2024-05-30
NCT03202095	WITHDRAWN	Major Depressive Disorder	University of Utah	2017-08-01	PHASE4
NCT05329480	UNKNOWN	Cardiac Function and Hemodynamics	Radford University	2022-02-09
NCT06202469	COMPLETED	Oligospermia; Sperm Count, Low	University of Novi Sad, Faculty of Sport and Physical Education	2023-12-15
NCT05383833	COMPLETED	Alzheimer's Disease	University of Kansas Medical Center	2022-12-12
NCT06371651	COMPLETED	Oxygen Deficiency	University of Novi Sad, Faculty of Sport and Physical Education	2024-03-01
NCT04286178	COMPLETED	Myositis, Juvenile	The Hospital for Sick Children	2021-04-06
NCT07033611	COMPLETED	Dialysis; Complications; Performance Enhancing Product Use	Carla Basualto Alarcón	2024-01-01
NCT06018480	COMPLETED	Endothelial Dysfunction	Florida State University	2023-08-29
NCT05877417	COMPLETED	Physical Inactivity	University of Central Florida	2023-05-17
NCT06059911	UNKNOWN	Sport Performance	Athanasios Z. Jamurtas	2022-06-15
NCT05994794	COMPLETED	Elevated S-adenosylhomocysteine	Standard Process Inc.	2022-12-09
NCT06482619	COMPLETED	Creatine; Patellar Tendinopathy	Universidad Pontificia Comillas	2021-01-01
NCT04504253	COMPLETED	Major Depressive Disorder	University of Utah	2020-08-03	PHASE3
NCT06172543	COMPLETED	Fatigue	Ward Dobbs	2023-03-01
NCT04395183	COMPLETED	Major Depressive Disorder	University of Utah	2021-03-01	PHASE2
NCT05745870	COMPLETED	Health Behavior	University of Idaho	2023-01-20	PHASE1
NCT04207359	COMPLETED	Breast Cancer; Chemotherapy Effect; Muscle Weakness; Muscle Loss; Exercise	The University of Texas Health Science Center at San Antonio	2020-09-30
NCT02463305	WITHDRAWN	Colitis, Ulcerative	University of Colorado, Denver	2022-08	EARLY_PHASE1
NCT02192931	COMPLETED	Depression; Dual Diagnosis; Drug Addiction	Perry Renshaw	2014-09	PHASE4
NCT05434845	UNKNOWN	Proteinuria in Pregnancy	Marshall University	2022-06-19
NCT04471792	COMPLETED	Peripheral Arterial Disease	Florida State University	2020-05-12	PHASE2
NCT05014659	COMPLETED	Endothelial Dysfunction; Oxidative Stress	Florida State University	2020-10-17
NCT05201651	UNKNOWN	Young Healthy Adults (no Medical Condition/Disease)	University of Regina	2022-02-10	EARLY_PHASE1
NCT07356193	COMPLETED	Muscle Damage; Plyometric Exercises; Creatine Kinase; Exercise Physiology	Batterjee Medical College	2022-02-13
NCT05981820	COMPLETED	Creatine; High Intensity Interval Training	Ankara University	2022-03-10
NCT05148208	UNKNOWN	Dialysis; Complications	University Medical Center Groningen	2022-01-01
NCT05451498	COMPLETED	Healthy	Rocky Mountain University of Health Professions	2022-02-09
NCT05697900	COMPLETED	Healthy Lifestyle	Dynamical Business and Science Society - DBSS International SAS	2021-06-01
NCT05109039	COMPLETED	Creatine	University of Idaho	2021-09-27
NCT04652921	COMPLETED	Sarcopenia	University of Novi Sad, Faculty of Sport and Physical Education	2020-09-15
NCT02757443	COMPLETED	Cardiac Surgical Procedures; Heart Valve Prosthesis Implantation	Meshalkin Research Institute of Pathology of Circulation	2016-06	PHASE3
NCT04298840	WITHDRAWN	Dihydrotestosterone; Testosterone; Hair Loss	Texas Tech University	2020-04
NCT02948244	COMPLETED	Facio-Scapulo-Humeral Dystrophy; FSHD2; FSHD1	Murdoch Childrens Research Institute	2017-10-31
NCT04665804	COMPLETED	Knee Osteoarthritis	Foundation University Islamabad	2020-06-10
NCT04423887	COMPLETED	Knee Osteoarthritis	Foundation University Islamabad	2020-06-10
NCT04423432	UNKNOWN	Knee Osteoarthritis	Foundation University Islamabad	2020-01-01
NCT03573583	COMPLETED	Sarcopenia	University of Florida	2019-02-01
NCT03678857	COMPLETED	Healthy	Brandon University	2018-09-15
NCT04290819	UNKNOWN	Performance Enhancing Product Use	University of Regina	2019-02-15
NCT02922725	TERMINATED	Major Depressive Disorder	Brent Michael Kious, MD, PhD	2016-11	PHASE4
NCT04058002	UNKNOWN	Knee Osteoarthritis	University of Sao Paulo General Hospital	2019-08-15
NCT04086381	COMPLETED	Diet-induced Thermogenesis; Brown Adipose Tissue Activation	Maastricht University	2018-05-01
NCT03941678	COMPLETED	Stroke	University of Saskatchewan	2019-05-30
NCT04007731	COMPLETED	Muscle Mass; Inflammation; Regeneration Muscle	Zala Jenko Praznikar	2019-07-01
NCT03138681	UNKNOWN	Major Depressive Disorder	Zhujiang Hospital	2017-05-03	PHASE2
NCT03352128	COMPLETED	Healthy; Creatine Supplementation	Vrije Universiteit Brussel	2018-09-10
NCT03698578	UNKNOWN	Healthy; Deficiency Diseases	São Paulo State University	2018-09-20
NCT02993874	UNKNOWN	Intermittent Claudication	State University of Maringá	2017-06-26
NCT03433651	WITHDRAWN	Depression	Mike O'Callaghan Military Hospital	2019-01-01	PHASE4
NCT02047864	COMPLETED	Osteoporosis; Sarcopenia	University of Saskatchewan	2014-01
NCT02062086	TERMINATED	Sarcopenia	University Hospital, Toulouse	2014-06
NCT01502813	COMPLETED	Cognitive Benefits	Deborah Yurgelun-Todd	2012-02-01
NCT03530202	UNKNOWN	Sarcopenia	University of Regina	2018-01-01	PHASE2
NCT03186053	UNKNOWN	Heart Valve Diseases	Chinese Academy of Medical Sciences, Fuwai Hospital	2017-06-15
NCT03350282	COMPLETED	Energy Metabolism	University of Novi Sad, Faculty of Sport and Physical Education	2016-12-01
NCT02661334	TERMINATED	Physical Fitness	David Grant U.S. Air Force Medical Center	2015-08-01
NCT01472393	UNKNOWN	Postmenopausal Women	University of Sao Paulo	2011-11
NCT01890382	COMPLETED	Frail Elderly Syndrome	University of Sao Paulo	2015-10-01
NCT02134808	COMPLETED	Major Depressive Disorder	Perry Renshaw	2014-11-21	PHASE4
NCT03411369	COMPLETED	Ischemic Heart Disease	University of Pavia	2016-06-01
NCT02961972	COMPLETED	Endothelial Dysfunction; Hyperhomocysteinemia	National Institute of Cardiology, Laranjeiras, Brazil	2015-01
NCT03006861	COMPLETED	Muscle Weakness	University of Saskatchewan	2016-12
NCT02267005	COMPLETED	Juvenile Dermatomyositis	The Hospital for Sick Children	2015-03
NCT02625779	WITHDRAWN	Depression, Bipolar	Ewha Womans University Mokdong Hospital	2016-03-01	PHASE2
NCT01543139	WITHDRAWN	Bipolar Depression	Ewha Womans University	2015-12-01	PHASE2
NCT05805540	COMPLETED	Cold-water Immersion; Protein-carbohydrates Supplementation; Active Recovery; Placebo	University of Cadiz	2017-02-01
NCT06832423	WITHDRAWN	Rock Climbing	Bangor University	2016-01
NCT02568878	RECRUITING	Depression; Anxiety; Methamphetamine Dependence	Montana State University	2015-11	PHASE3
NCT02356107	COMPLETED	Major Depressive Disorder	Perry Renshaw	2015-04	PHASE4
NCT03039829	COMPLETED	Nutritional Supplements	Texas A&M University	2016-01
NCT02290275	COMPLETED	Osteoarthritis, Knee	University of Manitoba	2015-01
NCT01655030	COMPLETED	Bipolar I Disorder; Current Episode Depressed	University of Sao Paulo	2012-07
NCT01381354	COMPLETED	Multiple Sclerosis	University of Iowa	2010-10	PHASE1
NCT02189915	TERMINATED	Depression; Dual Diagnosis; Substance Use	Perry Renshaw	2012-01
NCT02188849	COMPLETED	Muscle Weakness	University of Chile	2014-10	PHASE3
NCT02099357	COMPLETED	Spinal Cord Injuries	Universidade do Porto	2014-09
NCT02945241	COMPLETED	Methicillin-resistant Staphylococcus Aureus; Sepsis; Critical Illness	Mayo Clinic	2014-04	PHASE1
NCT02370212	COMPLETED	Healthy	University of British Columbia	2015-03
NCT01894737	COMPLETED	Muscle Loss	Maastricht University Medical Center	2013-10
NCT01803230	UNKNOWN	Healthy	University of Sao Paulo	2013-02
NCT01767844	UNKNOWN	Rheumatoid Arthritis	Bangor University	2013-01
NCT02519751	COMPLETED	Sports Nutritional Sciences	GlaxoSmithKline	2014-10
NCT00712426	TERMINATED	Huntington's Disease	Massachusetts General Hospital	2009-09	PHASE3
NCT01514630	COMPLETED	Depression; Substance Abuse; Substance Use; Neuroimaging; Dual Diagnosis	Perry Renshaw	2013-01	PHASE4
NCT03003988	COMPLETED	Dietary Supplementation	Texas A&M University	2014-09
NCT03000582	COMPLETED	Dietary Modification	Texas A&M University	2014-06
NCT02094781	COMPLETED	Nutritional Status	GlaxoSmithKline	2013-12	PHASE1
NCT02058654	COMPLETED	Nutritional Status	GlaxoSmithKline	2013-12-01	PHASE1
NCT01601210	COMPLETED	Major Depressive Disorder	Perry Renshaw	2012-06	EARLY_PHASE1
NCT01175616	WITHDRAWN	Major Depressive Disorder	University of Utah	2012-09	PHASE4
NCT01968577	UNKNOWN	Coronary Artery Disease	Kleber Bomfim Araujo Martins	2011-03	PHASE4
NCT00449865	TERMINATED	Parkinson's Disease	University of Rochester	2007-03	PHASE3
NCT03194334	COMPLETED	Dietary Modification	University Ghent	2012-12
NCT01725503	COMPLETED	Creatine Synthesis in Healthy Subjects	The Cleveland Clinic	2010-01
NCT01411163	COMPLETED	Huntington's Disease	Massachusetts General Hospital	2010-04	PHASE2
NCT01817673	COMPLETED	Healthy Persons	University of Sao Paulo	2011-07
NCT01257581	COMPLETED	Amyotrophic Lateral Sclerosis	Nazem Atassi	2011-03	PHASE2
NCT01164020	COMPLETED	Cognition; Aging	University of Sao Paulo	2010-08
NCT00851006	COMPLETED	Major Depressive Disorder	University of Utah	2009-04	PHASE2
NCT01411150	COMPLETED	Huntington's Disease	Massachusetts General Hospital	2009-05	PHASE2
NCT00592995	COMPLETED	Huntington Disease	Massachusetts General Hospital	2007-12	PHASE2
NCT01217320	UNKNOWN	Juvenile Systemic Lupus Erythematosus; Juvenile Dermatomyositis	University of Sao Paulo	2011-01
NCT00749983	COMPLETED	Knee Osteoarthritis; Fibromyalgia	University of Sao Paulo	2009-06
NCT00729755	COMPLETED	Major Depressive Disorder	Ewha Womans University	2008-08
NCT01057680	COMPLETED	Osteoporosis; Sarcopenia	University of Saskatchewan	2010-01	PHASE3
NCT01025518	COMPLETED	Head and Neck Neoplasms	Danish Head and Neck Cancer Group	2009-09
NCT01412151	COMPLETED	Huntington's Disease (HD)	Massachusetts General Hospital	2005-04	PHASE2
NCT01163370	COMPLETED	Osteopenia; Osteoporosis	University of Sao Paulo	2010-07
NCT01213719	COMPLETED	Healthy Subjects	University of Sao Paulo	2010-10
NCT01050556	COMPLETED	High Blood Arsenic Due to Chronic Arsenic Exposure	Columbia University	2010-09	PHASE4
NCT00313417	TERMINATED	Major Depressive Disorder	Herzog Hospital	2007-01	PHASE4
NCT00348933	COMPLETED	Angelman Syndrome; Nervous System Diseases	University of California, San Diego	2006-07
NCT00605930	COMPLETED	Progressive Supranuclear Palsy	University of Louisville	2004-04
NCT01367717	COMPLETED	Acute Kidney Injury	Beth Israel Medical Center	2009-05
NCT01147575	COMPLETED	Rett Syndrome	Medical University of Vienna	2005-01
NCT00081250	COMPLETED	Anorexia; Cachexia; Unspecified Adult Solid Tumor, Protocol Specific; Weight Changes	Alliance for Clinical Trials in Oncology	2004-12	PHASE3
NCT00797407	COMPLETED	Hypercholesterolemia; Aches; Cramps; Weakness	The Cleveland Clinic	2006-08
NCT00140192	COMPLETED	Schizophrenia	Beersheva Mental Health Center	2004-09	PHASE3
NCT00063193	COMPLETED	Parkinson's Disease	University of Rochester	2003-05	PHASE2
NCT00005766	COMPLETED	Amyotrophic Lateral Sclerosis	National Center for Research Resources (NCRR)		PHASE2
NCT00018109	COMPLETED	Muscular Dystrophy, Duchenne	National Center for Research Resources (NCRR)		PHASE3
NCT00016653	COMPLETED	Muscular Dystrophy, Duchenne	Cooperative International Neuromuscular Research Group	2000-06	PHASE2; PHASE3
NCT00551434	COMPLETED	Coronary Artery Disease	Boston University	2002-08
NCT00026988	COMPLETED	Huntington's Disease	National Center for Complementary and Integrative Health (NCCIH)	2001-10	PHASE1; PHASE2
NCT00992043	COMPLETED	Diabetes; Renal Function	University of Sao Paulo	2009-10
NCT00484627	COMPLETED	HIV Infections	National Center for Complementary and Integrative Health (NCCIH)	2001-08	PHASE2
NCT00005674	COMPLETED	Amyotrophic Lateral Sclerosis	National Center for Research Resources (NCRR)		PHASE2
NCT00070993	COMPLETED	Amyotrophic Lateral Sclerosis	National Center for Complementary and Integrative Health (NCCIH)	2002-12	PHASE2
NCT00069186	UNKNOWN	Amyotrophic Lateral Sclerosis (ALS)	The Avicena Group	2003-06	PHASE3
NCT00465140	COMPLETED	Renal Insufficiency	University of Sao Paulo	2004-01
NCT00355576	COMPLETED	Amyotrophic Lateral Sclerosis	Columbia University	2006-07	PHASE2
NCT00473902	COMPLETED	Sarcopenia	Hamilton Health Sciences Corporation	2003-08

(data from https://clinicaltrials.gov, updated on 2026-08-10)

Check the Creatine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Creatine facilitates rapid adenosine triphosphate recycling in muscle and neural tissues while directly inhibiting the interaction of interferon-gamma receptors with Janus kinase 2. By suppressing downstream signal transducer and activator of transcription 1-mediated pro-inflammatory gene expression and maintaining cellular bioenergetics, creatine mitigates energy failure and inflammation across clinical conditions such as major depressive disorder, chronic obstructive pulmonary disease, and myocardial ischemia.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).