CAS No. 95809-78-2
| IUPAC Name | 6,8-bis(benzylsulfanyl)octanoic acid | |
|---|---|---|
| CAS Number | 95809-78-2 | |
| Molecular Formula |
C22H28O2S2 |
|
| Molecular Weight (MW) | 388.59 | |
| SMILES | C1=CC=C(C=C1)CSCCC(CCCCC(=O)O)SCC2=CC=CC=C2 | |
| InChIKey | ZYRLHJIMTROTBO-UHFFFAOYSA-N |
CPI-613 (Devimistat) is a lipoic acid analog and inhibitor of mitochondrial energy metabolism that targets pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes. By suppressing pyruvate dehydrogenase activity, CPI-613 disrupts mitochondrial respiration and alters cancer cell metabolic flux. This metabolic impairment reduces mitochondrial membrane potential, increases reactive oxygen species production, and induces apoptosis across multiple tumor cell lines, while exhibiting potent antitumor activity in human tumor xenograft models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 78 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 78 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- CPI-613 (Devimistat) Mechanism of Action: PDH Inhibition in Pancreatic Adenocarcinoma Cell Research
- CPI-613 (Devimistat) Clinical Trials
- CPI-613 (Devimistat) Working Concentration | Cell Culture | Treatment
- CPI-613 (Devimistat) Solubility in DMSO
- CPI-613 (Devimistat) Stock Solution
- CPI-613 (Devimistat) Storage
- CPI-613 (Devimistat) Stability
- CPI-613 (Devimistat) Combination Database
- CPI-613 (Devimistat) Molecular Weight
- CPI-613 (Devimistat) SMILES
- CPI-613 (Devimistat) Chemical Structure (2D and 3D)
- CPI-613 (Devimistat) IC50 for Cell-based and Cell-free Assays
- CPI-613 (Devimistat) APExBIO (A4333)? Try a better option.
- CPI-613 (Devimistat) Sigma (SML0404)? Try a better option.
- CPI-613 (Devimistat) Cayman (16981)? Try a better option.
- CPI-613 (Devimistat) MedChemExpress (HY-15453)? Try a better option.
- CPI-613 (Devimistat) SDS｜MSDS