CAS No. 15663-27-1
Batch:
Purity:99.84
Chemical Structure
Check the
Cisplatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | azane;dichloroplatinum | |
|---|---|---|
| CAS Number | 15663-27-1 | |
| Molecular Formula |
Cl2H6N2Pt |
|
| Molecular Weight (MW) | 300.05 | |
| SMILES | [NH2-].[NH2-].Cl[Pt+2]Cl | |
| InChIKey | LXZZYRPGZAFOLE-UHFFFAOYSA-L |
Biological Activity
Cisplatin is an inorganic platinum complex that functions as a DNA synthesis inhibitor by binding DNA and forming intra- and interstrand covalent adducts in tumor cells. These platinum-DNA crosslinks block normal DNA replication and transcription, ultimately triggering signaling cascades that lead to apoptosis. In addition to apoptotic signaling, cisplatin treatment activates ferroptosis and induces autophagy to modulate cancer cell survival and death responses. [1][2]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMF | 15 mg/mL |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMF | 2.5 mg/mL |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
| Water | 3 mg/mL |
| DMF | 10 mg/mL |
| Water | 1 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Cisplatin Mechanism of Action: ERCC1 Inhibition in Non-Small Cell Lung Cancer Cell Research
- Cisplatin Clinical Trials
- Cisplatin Working Concentration | Cell Culture | Treatment
- Cisplatin Solubility in DMSO
- Cisplatin Storage
- Cisplatin Stability
- Cisplatin Combination Database
- Cisplatin Molecular Weight
- Cisplatin SMILES
- Cisplatin Chemical Structure (2D and 3D)
- Cisplatin IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.