Cilengitide is a potent, selective cyclic RGD peptide and integrin αvβ3/αvβ5 antagonist. It affects FAK/Src/AKT, TGF-β1/Smad, and Ras/ERK/AKT signaling pathways by blocking integrin-mediated signaling, effectively inhibiting tumor cell adhesion, migration, and proliferation, and promoting apoptosis.
Cilengitide (EMD 121974) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Cilengitide (EMD 121974) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.