CAS No. 188968-51-6

Batch: Purity:99.63
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Cilengitide (EMD 121974) Chemical Structure
Chemical Structure
Check the Cilengitide (EMD 121974) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CAS Number 188968-51-6
Molecular Formula

C27H40N8O7
Molecular Weight (MW) 588.66
SMILES CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O
InChIKey AMLYAMJWYAIXIA-VWNVYAMZSA-N

Ordering Information

Biological Activity

Cilengitide (EMD 121974) is a selective cyclic peptide inhibitor targeting integrin αvβ3 and integrin αvβ5. By disrupting integrin-mediated cell adhesion and extracellular matrix interactions, it suppresses downstream focal adhesion kinase (FAK) signaling pathways. This inhibition impairs endothelial cell migration, blocks capillary-like tube formation, and induces apoptosis, thereby exerting potent anti-angiogenic and anti-tumor activity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (169.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 5 mg/mL (超声加热十分钟，60℃)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.