CH-223191 is a potent, selective aryl hydrocarbon receptor (AhR) antagonist. It blocks AhR signaling by preventing ligand-induced nuclear translocation and DNA binding, effectively inhibiting TCDD-induced CYP1A1 expression and Th17 cell differentiation.
CH-223191 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for CH-223191 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.