CAS No. 301326-22-7
Batch:
Purity:99.75
Chemical Structure
Check the
CH-223191
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide | |
|---|---|---|
| CAS Number | 301326-22-7 | |
| Molecular Formula |
C19H19N5O |
|
| Molecular Weight (MW) | 333.39 | |
| SMILES | CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C | |
| InChIKey | LKTNEXPODAWWFM-UHFFFAOYSA-N |
CH-223191 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist with an IC50 of. It blocks ligand binding to AhR, preventing receptor nuclear translocation and activation of AhR-driven transcription. By inhibiting AhR signaling, CH-223191 suppresses downstream expression of cytochrome P450 enzymes, such as CYP1A1, thereby mitigating AhR-mediated immune modulation, inflammatory responses, and xenobiotic toxicity in various cell types. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
67 mg/mL
(200.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
67 mg/mL
(200.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | ˂1 mg/mL |
| DMSO |
67 mg/mL
(200.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
33.5 mg/mL
(100.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- CH-223191 Mechanism of Action: AhR Inhibition in T Cell Research
- CH-223191 Working Concentration | Cell Culture | Treatment
- CH-223191 Solubility in DMSO
- CH-223191 Stock Solution
- CH-223191 Storage
- CH-223191 Stability
- CH-223191 Combination Database
- CH-223191 Molecular Weight
- CH-223191 SMILES
- CH-223191 Chemical Structure (2D and 3D)
- CH-223191 IC50 for Cell-based and Cell-free Assays
- CH-223191 Sigma (C8124)? Try a better option.
- CH-223191 MedChemExpress (HY-12684)? Try a better option.
- CH-223191 Cayman (16154)? Try a better option.
- CH-223191 STEMCELL (72732)? Try a better option.
- CH-223191 Tocris (3858)? Try a better option.
- CH-223191 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.