For research use only. Not for use in humans.

Cabiralizumab (Anti-CSF1R / M-CSFR / CD115)

Synonyms: FPA 008 Cat.No.A2644 Purity:99%

Cabiralizumab (Anti-CSF1R / M-CSFR / CD115) is an monoclonal antibody (MAb) targeting CSF1R. It can be used in the research of rheumatoid arthritis (RA), melanoma, kidney cancer, or non-small cell lung cancer. MW :146.3 KD.

Quality Control

Batch: A264401 Purity: 99% Protein concentration: 5.74mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	CSF-1R	Others
Linifanib (ABT-869)	33	++++	VEGFR1/FLT1,FLT3,VEGFR2/KDR
ENMD-2076	9	+	FLT3,RET,Aurora A
OSI-930	7	++	FLT1,KDR,LCK
GW2580	17	+
Agerafenib (CEP-32496)	6	+++	RET,PDGFRβ,LCK
Vimseltinib	0	++	c-Kit
Edicotinib(JNJ-40346527)	2	+++
Chiauranib	0	+++	c-Kit,VEGFR2,Aurora B
ARRY-382	0	+++
Elzovantinib (TPX-0022)	0	++++	SRC,MET
Ki20227	1	++++	VEGFR2,PDGFRβ,c-Kit
Sulfatinib	1	+++	VEGFR3,VEGFR1,FGFR1
PLX5622	14	++	FLT3,KIT,AURKC
PRN1371	2	+++	FGFR1,FGFR2,FGFR3
Sotuletinib (BLZ945)	34	++++
Pimicotinib	0	✔
CSF1R-IN-1	1	✔
AZD7507	0	✔
PDGFR inhibitor 1	3	✔	PDGFR,Kit,VEGFR2

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Cabiralizumab (Anti-CSF1R / M-CSFR / CD115) is an monoclonal antibody (MAb) targeting CSF1R. It can be used in the research of rheumatoid arthritis (RA), melanoma, kidney cancer, or non-small cell lung cancer. MW :146.3 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/34140403/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1613144-80-1
Molecular Weight	146.3
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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