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Bulevirtide (Myrcludex B)

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.

Bulevirtide (Myrcludex B) Chemical Structure

Bulevirtide (Myrcludex B) Chemical Structure

CAS: 2012558-47-1

Purity & Quality Control

Batch: Purity: 99.89%
99.89

Products often used together with Bulevirtide (Myrcludex B)

Tenofovir Disoproxil Fumarate

Bulevirtide (Myrcludex B) and Tenofovir Disoproxil Fumarate use show effectiveness in the treatment of HDV-related compensated cirrhosis.

Loglio A, et al. J Hepatol. 2019;71(4):834-839.

Lonafarnib (SCH66336)

Bulevirtide (Myrcludex B) and Lonafarib efficiently suppress hepatitis delta virus (HDV) RNA.

Winer BY, et al. Sci Transl Med. 2018;10(447):eaap9328.

FTI 277 HCl

Bulevirtide (Myrcludex B) and FTI 277 are used to treat hepatitis delta virus.

Abbas Z, et al. World J Gastroenterol. 2015;21(32):9461-9465.

Tenofovir

Bulevirtide (Myrcludex B) and Tenofovir are used to treat hepatitis B virus infections.

Lamivudine

Bulevirtide (Myrcludex B) and Lamivudine validate the use of HC3x-AA-HLC model, in antiviral drug studies.

Tricot T, et al. Biomedicines. 2022 Jan 26;10(2):268.

Bulevirtide (Myrcludex B) Related Products

Biological Activity

Description Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
Targets
NTCP [1]
∼80 pM
In vitro
In vitro

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt. transport.
Cell Research Cell lines U2OS cells
Concentrations 200 nM
Incubation Time 1 h
Method

Cells were treated with indicated concentration of drug for 1 h.

Chemical Information & Solubility

Molecular Weight 5398.86 Formula

C248H355N65O72
CAS No. 2012558-47-1 SDF --
Density 95.0~105.0%
Storage (From the date of receipt) 3 years-20°C powder Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 100 mg/mL ( (18.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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