L-BSO is a potent γ-GCS inhibitor. It affects AKT and MAPK pathways by depleting GSH to increase ROS, promoting apoptosis.
Comprehensive IC50 Values for L-Buthionine-(S,R)-sulfoximine (L-BSO) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
L-BSO is a potent γ-GCS inhibitor. It affects AKT and MAPK pathways by depleting GSH to increase ROS, promoting apoptosis.