CAS No. 83730-53-4
Batch:
Purity:98.904
Chemical Structure
Check the
L-Buthionine-(S,R)-sulfoximine (L-BSO)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid | |
|---|---|---|
| CAS Number | 83730-53-4 | |
| Molecular Formula |
C8H18N2O3S |
|
| Molecular Weight (MW) | 222.31 | |
| SMILES | CCCC[S](=N)(=O)CCC(N)C(O)=O | |
| InChIKey | KJQFBVYMGADDTQ-CVSPRKDYSA-N |
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, fast-acting, and irreversible inhibitor of γ-glutamylcysteine synthetase (γ-GCS). By inhibiting γ-GCS, it blocks de novo glutathione synthesis and rapidly depletes intracellular glutathione levels. This disruption of cellular redox homeostasis impairs antioxidant defense mechanisms, thereby increasing cellular susceptibility to oxidative stress and promoting apoptosis in various tumor cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 44 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 44 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 40 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Mechanism of Action: γ-GCS Inhibition in Cancer Cells Research
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Clinical Trials
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Working Concentration | Cell Culture | Treatment
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Solubility in DMSO
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Stock Solution
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Storage
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Stability
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Combination Database
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Molecular Weight
- L-Buthionine-(S,R)-sulfoximine (L-BSO) SMILES
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Chemical Structure (2D and 3D)
- L-Buthionine-(S,R)-sulfoximine (L-BSO) IC50 for Cell-based and Cell-free Assays
- L-Buthionine-(S,R)-sulfoximine (L-BSO) Sigma (B2515)? Try a better option.
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- L-Buthionine-(S,R)-sulfoximine (L-BSO) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.