CAS No. 1365888-06-7

Batch: Purity:99.98
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Brilanestrant (GDC-0810) Chemical Structure
Chemical Structure
Check the Brilanestrant (GDC-0810) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1365888-06-7
Molecular Formula

C26H20ClFN2O2
Molecular Weight (MW) 446.90
SMILES CCC(=C(C1=CC=C(C=C1)C=CC(=O)O)C2=CC3=C(C=C2)NN=C3)C4=C(C=C(C=C4)F)Cl

Ordering Information

Biological Activity

Brilanestrant (GDC-0810) is a potent, nonsteroidal selective estrogen receptor degrader and full transcriptional antagonist that targets ER-α and ER-β. It induces the targeted degradation of ER-α without displaying intrinsic agonism, thereby inhibiting downstream estrogen receptor signaling pathways. Consequently, Brilanestrant blocks transcriptional activation, suppresses cell proliferation, and reduces cell viability in estrogen receptor-positive breast cancer models, including MCF-7 cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 89 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.