Home Endocrinology & Hormones Melanocortin Receptor Bremelanotide Acetate For research use only.

Bremelanotide Acetate

Synonyms:

Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

Bremelanotide Acetate Chemical Structure

Bremelanotide Acetate Chemical Structure

CAS: 1607799-13-2

Purity & Quality Control

Batch: P110801 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.97%
99.97

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Biological Activity

Description Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.
In Vivo
In vivo

Bremelanotide, an analogue of the naturally occurring peptide a-MSH, activates the medial preoptic area (mPOA) and other hypothalamic and limbic regions of the brain involved in sexual behavior, and may work by activating dopamine terminals in the mPOA.[2]
Animal Research Animal Models rat model of sexual desire
Dosages 5, 100, 200, 800 μg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 1085.22 Formula

C50H68N14O10.C2H4O2
CAS No. 1607799-13-2 SDF --
Density 95.0~105.0%
Smiles CCCCC(NC(C)=O)C(=O)NC1CC(=O)NCCCCC(NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=C[NH]5)NC1=O)C(O)=O.CC(O)=O
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (92.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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