Bortezomib: Selectivity & Specificity

Bortezomib is a potent inhibitor of E. coli ClpP (40 nM), SARS-CoV-2 3CL Protease (277000 nM), Hc-PBS-5 (from H. contortus L3) (621.8 nM), Recombinant LonP1 monomer (1200 nM), PSMB5 (2.7 nM), PSMB6, PSMB7, and HTRA2. Bortezomib exhibits the greatest inhibitory potency toward PSMB5 (IC50 = 2.7 nM).