Clinical Trials

Numerous clinical trials, spanning Early Phase 1 through Phase 3, evaluate bortezomib across a broad range of oncological and immunological conditions, including multiple myeloma, mantle cell lymphoma, non-small cell lung cancer, and immune thrombocytopenia. Sponsored by major academic institutions and pharmaceutical organizations, these studies currently encompass active recruiting, completed, active not recruiting, and terminated cohorts.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07428369 WITHDRAWN
Multiple Myeloma (MM)
Regeneron Pharmaceuticals
2026-06-05 PHASE2; PHASE3
NCT07072585 NOT_YET_RECRUITING
Stage II T Lymphoblastic Leukemia/Lymphoma; Stage III T Lymphoblastic Leukemia/Lymphoma; Stage IV T Lymphoblastic Leukemia/Lymphoma; T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma
Children's Oncology Group
2026-08-28 PHASE2; PHASE3
NCT07793422 NOT_YET_RECRUITING
Amyloid Light Chain (AL) Amyloidosis
AbbVie
2026-11-29 PHASE3
NCT07624513 NOT_YET_RECRUITING
Multiple Myeloma
Dana-Farber Cancer Institute
2026-06-08 PHASE3
NCT05257083 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Stichting European Myeloma Network
2023-10-10 PHASE3
NCT07285239 RECRUITING
Multiple Myeloma
PrECOG, LLC.
2026-09 PHASE3
NCT05561387 RECRUITING
Plasma Cell Myeloma
SWOG Cancer Research Network
2023-10-12 PHASE3
NCT07247097 NOT_YET_RECRUITING
Multiple Myeloma; Newly Diagnosed Multiple Myeloma; Transplant Ineligible; Newly Diagnosed Multiple Myeloma (NDMM)
Massachusetts General Hospital
2026-08-01 PHASE2
NCT07665450 NOT_YET_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2026-09-22 PHASE3
NCT06577025 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2024-08-20 PHASE2
NCT06015750 WITHDRAWN
Hypophosphatasia
Alexion Pharmaceuticals, Inc.
2026-07-29 PHASE4
NCT04240054 RECRUITING
Multiple Myeloma
Medical College of Wisconsin
2021-11-02 PHASE2
NCT07464210 NOT_YET_RECRUITING
Waldenstrom Macroglobulinemia
Seoul National University Hospital
2026-06-01 PHASE2
NCT07601100 NOT_YET_RECRUITING
Newly Diagnosed Multiple Myeloma
Dana-Farber Cancer Institute
2026-09-03 PHASE1; PHASE2
NCT07623798 NOT_YET_RECRUITING
Relapsed or Refractory Multiple Myeloma
Innovent Biologics (Suzhou) Co. Ltd.
2026-06-05 PHASE3
NCT07614360 NOT_YET_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2026-08-03 PHASE2
NCT07764978 RECRUITING
Newly Diagnosed Multiple Myeloma
AstraZeneca
2026-06-26 PHASE3
NCT06636552 RECRUITING
Primary Plasma Cell Leukemia
Hellenic Society of Hematology
2021-11-19 PHASE2
NCT07709715 NOT_YET_RECRUITING
Light Chain (AL) Amyloidosis
Nexcella Inc.
2027-01 PHASE3
NCT05695508 RECRUITING
Multiple Myeloma
University of Heidelberg Medical Center
2022-12-01 PHASE2
NCT03643276 RECRUITING
Acute Lymphoblastic Leukemia, Pediatric
Martin Schrappe
2018-07-15 PHASE3
NCT07391657 RECRUITING
Relapsed Refractory Multiple Myeloma
AstraZeneca
2026-02-23 PHASE3
NCT07045909 RECRUITING
De Novo Multiple Myeloma; Anitocabtagene Autoleucel
PETHEMA Foundation
2025-06-30 PHASE2
NCT05137054 RECRUITING
Multiple Myeloma
Regeneron Pharmaceuticals
2022-08-17 PHASE1
NCT03850366 RECRUITING
Hematological Malignancy
Henry Ford Health System
2016-03-08 PHASE2
NCT04414475 RECRUITING
Multiple Myeloma, Refractory
Karyopharm Therapeutics Inc
2020-07-01 PHASE2
NCT03590171 RECRUITING
Acute Lymphoblastic Leukemia (ALL)
Charite University, Berlin, Germany
2017-09-01 PHASE2
NCT07008638 RECRUITING
Acute Myeloid Leukemia; TP53
Masonic Cancer Center, University of Minnesota
2025-07-07 PHASE1; PHASE2
NCT04775550 ACTIVE_NOT_RECRUITING
High-risk Smoldering Multiple Myeloma; Multiple Myeloma
Omar Nadeem, MD
2021-03-08 PHASE2
NCT07388602 RECRUITING
Amyloidosis
Sinocelltech Ltd.
2026-01-08 PHASE3
NCT06158841 ACTIVE_NOT_RECRUITING
Multiple Myeloma
AbbVie
2024-05-19 PHASE3
NCT06142396 RECRUITING
Multiple Myeloma; Renal Failure
Augusta University
2024-11-01 EARLY_PHASE1
NCT07018050 RECRUITING
Relapsed or Refractory Multiple Myeloma
Qilu Pharmaceutical Co., Ltd.
2025-09-12 PHASE2
NCT07789522 NOT_YET_RECRUITING
Multiple Myeloma (MM)
Institute of Hematology & Blood Diseases Hospital, China
2026-10-01 PHASE2
NCT06681922 RECRUITING
Graft Vs Host Disease
Northwell Health
2024-09-23 PHASE1; PHASE2
NCT04790474 ACTIVE_NOT_RECRUITING
Multiple Myeloma in Relapse; Refractory Multiple Myeloma
Tel-Aviv Sourasky Medical Center
2021-03-25 PHASE2
NCT03136146 RECRUITING
Recurrent Acute Lymphoblastic Leukemia; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Burkitt Leukemia; Recurrent Burkitt Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Refractory Acute Lymphoblastic Leukemia; Refractory Burkitt Leukemia; Refractory Burkitt Lymphoma; Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Refractory Lymphoblastic Lymphoma
M.D. Anderson Cancer Center
2017-08-09 PHASE2
NCT05665140 RECRUITING
Newly Diagnosed Multiple Myeloma
University Hopsital Schleswig Holstein Campus Lübeck
2023-02-03 PHASE2; PHASE3
NCT00572169 ACTIVE_NOT_RECRUITING
Multiple Myeloma
University of Arkansas
2006-11 PHASE3
NCT05470491 RECRUITING
HIV; Hematologic Malignancies
National Cancer Institute (NCI)
2023-01-26 PHASE1; PHASE2
NCT06348147 WITHDRAWN
Newly Diagnosed Multiple Myeloma; Multiple Myeloma; Autologous Stem Cell Transplantation
UNC Lineberger Comprehensive Cancer Center
2026-07 PHASE2
NCT03319667 ACTIVE_NOT_RECRUITING
Plasma Cell Myeloma
Sanofi
2017-12-07 PHASE3
NCT05558319 RECRUITING
Newly Diagnosed Multiple Myeloma
PETHEMA Foundation
2022-11-10 PHASE3
NCT04166565 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Extramedullary Plasmacytoma
Stichting European Myeloma Network
2019-10-31 PHASE2
NCT04133636 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2019-11-07 PHASE2
NCT05736419 RECRUITING
Sickle Cell Disease; Thalassemia, Beta; Thalassemia
Memorial Sloan Kettering Cancer Center
2023-02-09 PHASE2
NCT05519085 RECRUITING
Relapsed or Refractory Multiple Myeloma
Celgene
2022-09-20 PHASE3
NCT03829371 ACTIVE_NOT_RECRUITING
Multiple Myeloma
University of Turin, Italy
2019-01-03 PHASE4
NCT05681260 RECRUITING
T-cell Lymphoblastic Lymphoma
Children's Cancer Group, China
2023-02-06 PHASE3
NCT05514990 ACTIVE_NOT_RECRUITING
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
University of Southern California
2022-10-07 PHASE1; PHASE2
NCT02718833 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Massachusetts General Hospital
2016-06-21 PHASE2
NCT03989414 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Celgene
2019-09-30 PHASE1; PHASE2
NCT06505369 RECRUITING
Multiple Myeloma
North Estonia Medical Centre
2024-06-19 PHASE2
NCT06083922 RECRUITING
Multiple Myeloma; Monoclonal Gammopathy of Renal Significance
Memorial Sloan Kettering Cancer Center
2023-10-16 PHASE2
NCT03117751 ACTIVE_NOT_RECRUITING
Acute Lymphoblastic Leukemia; Acute Lymphoblastic Lymphoma
St. Jude Children's Research Hospital
2017-03-29 PHASE2; PHASE3
NCT05392946 ACTIVE_NOT_RECRUITING
Plasma Cell Myeloma
Mayo Clinic
2022-08-11 PHASE1; PHASE2
NCT06152575 RECRUITING
Multiple Myeloma
Pfizer
2024-02-08 PHASE3
NCT05289167 RECRUITING
Graft-versus-host Disease
Northwell Health
2022-03-13 PHASE1; PHASE2
NCT03589222 ACTIVE_NOT_RECRUITING
Refractory Multiple Myeloma
PETHEMA Foundation
2018-07-15 PHASE2
NCT03697356 UNKNOWN
Waldenström's Macroglobulinemia
Kosin University Gospel Hospital
2019-03-06 PHASE2
NCT02783625 COMPLETED
Lymphoma; Relapsed/Refractory T-cell Lymphomas
Memorial Sloan Kettering Cancer Center
2016-05-23 PHASE1
NCT05776940 UNKNOWN
Immunoglobulin Light-chain Amyloidosis
Air Force Military Medical University, China
2023-03-31 PHASE3
NCT05849610 ACTIVE_NOT_RECRUITING
High-Risk de Novo Multiple Myeloma
PETHEMA Foundation
2023-09-21 PHASE2
NCT02719613 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2016-07-15 PHASE2
NCT03844360 RECRUITING
Hematological Neoplasms
Wei Zhao
2016-01-31 PHASE4
NCT06771180 NOT_YET_RECRUITING
Monoclonal Gammopathy of Renal Significance (MGRS)
Peking University People's Hospital
2025-01-15 PHASE2
NCT06418477 RECRUITING
Monoclonal Gammopathy of Renal Significance
Peking University People's Hospital
2024-06-15 PHASE2
NCT03641456 UNKNOWN
Myeloma; Newly Diagnosed; High Risk
Sun Yat-sen University
2020-09-25 PHASE2
NCT05895201 WITHDRAWN
Bone Marrow Transplant Complications; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia, Adult; Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia
Indiana University
2023-11 PHASE1; PHASE2
NCT06203145 UNKNOWN
Multiple Myeloma; Renal Injury
Peking University First Hospital
2024-01-02
NCT05572515 ACTIVE_NOT_RECRUITING
Relapsed or Refractory Multiple Myeloma
Janssen Research & Development, LLC
2023-03-29 PHASE3
NCT04722146 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2021-03-12 PHASE1
NCT03188172 UNKNOWN
Multiple Myeloma
University of Leeds
2017-09-28 PHASE2
NCT05083169 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2021-10-14 PHASE3
NCT02211755 COMPLETED
Neoplasms; Myelodysplastic Syndromes; Lymphomas
National Cancer Institute (NCI)
2014-10-06 PHASE1
NCT04626791 ACTIVE_NOT_RECRUITING
Mantle Cell Lymphoma
Academic and Community Cancer Research United
2021-08-03 PHASE2
NCT04717700 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Ida Bruun Kristensen
2021-08-18 PHASE2
NCT03942224 UNKNOWN
Plasma Cell Myeloma
Emory University
2019-07-03 PHASE2
NCT05123131 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Cancer Trials Ireland
2022-04-01 PHASE2
NCT04091126 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2019-12-18 PHASE1
NCT04504825 ACTIVE_NOT_RECRUITING
AL Amyloidosis
Alexion Pharmaceuticals, Inc.
2020-08-25 PHASE3
NCT04570631 TERMINATED
Multiple Myeloma
AbbVie
2020-11-05 PHASE1
NCT04802356 ACTIVE_NOT_RECRUITING
Multiple Myeloma
PETHEMA Foundation
2021-04-07 PHASE2
NCT04131309 COMPLETED
Light Chain (AL) Amyloidosis, Stage 3B
Stichting European Myeloma Network
2019-09-23 PHASE2
NCT06189833 UNKNOWN
Multiple Myeloma
Stichting European Myeloma Network
2023-11-23 PHASE2
NCT05147493 UNKNOWN
Multiple Myeloma; Renal Impairment; Neoplasms, Plasma Cell; Neoplasms by Histologic Type; Neoplasms; Paraproteinemias; Blood Protein Disorders; Hematologic Diseases
Hellenic Society of Hematology
2022-04 PHASE2
NCT03129828 COMPLETED
Diffuse Large B Cell Lymphoma
Prof. Dr. Clemens Schmitt
2017-03-17 PHASE1; PHASE2
NCT04285268 WITHDRAWN
High Grade B-Cell Lymphoma, Not Otherwise Specified; Recurrent Burkitt Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements; Refractory Burkitt Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
Rutgers, The State University of New Jersey
2020-05-06 PHASE2
NCT04939844 COMPLETED
Multiple Myeloma
Oslo University Hospital
2021-06-29 PHASE2
NCT04423367 COMPLETED
Acquired Pure Red Cell Aplasia
Institute of Hematology & Blood Diseases Hospital, China
2020-09-13 PHASE2
NCT03737136 COMPLETED
Antibody-mediated Rejection
Shahid Beheshti University of Medical Sciences
2019-11-01
NCT01919086 COMPLETED
Multiple Myeloma (MM)
Memorial Sloan Kettering Cancer Center
2013-08-06 PHASE2
NCT04140162 ACTIVE_NOT_RECRUITING
Multiple Myeloma
University of Michigan Rogel Cancer Center
2020-10-05 PHASE2
NCT06868667 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2021-07-28 PHASE3
NCT04484623 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2020-10-01 PHASE3
NCT04352205 TERMINATED
Plasma Cell Myeloma; Renal Failure
Emory University
2020-05-07 PHASE2
NCT05383547 UNKNOWN
Bortezomib; Glomerulonephritis; MN; MPGN; FSGS; IgA Nephropathy
Ruijin Hospital
2022-08-02
NCT05564052 COMPLETED
Lymphoma, Mantle-Cell
Janssen Research & Development, LLC
2022-12-06 PHASE2
NCT04304144 COMPLETED
AL Amyloidosis
Alexion Pharmaceuticals, Inc.
2020-03-18 PHASE2
NCT04392648 WITHDRAWN
Relapsed and/or Refractory Multiple Myeloma
Teva Branded Pharmaceutical Products R&D LLC
2020-06-24 PHASE1
NCT04151667 COMPLETED
Multiple Myeloma
H. Lee Moffitt Cancer Center and Research Institute
2019-11-22 PHASE2
NCT04996160 COMPLETED
Acute Lymphoblastic Leukemia, Pediatric; Relapsed Acute Lymphoblastic Leukemia; Refractory Acute Lymphoblastic Leukemia
Tanja Andrea Gruber
2021-07-09 PHASE1
NCT05293509 WITHDRAWN
Stem Cell Transplantation
M.D. Anderson Cancer Center
2022-03-02 PHASE2
NCT05982756 UNKNOWN
Bortezomib; Acute Myeloid Leukemia
Zhongnan Hospital
2020-01-01 PHASE1
NCT03710603 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Stichting European Myeloma Network
2018-12-14 PHASE3
NCT03742297 ACTIVE_NOT_RECRUITING
Newly Diagnosed Multiple Myeloma
PETHEMA Foundation
2018-10-22 PHASE3
NCT05599880 Recruiting
Relapsed/Refractory Immune Thrombocytopenia
Seoul National University Hospital
2023-07-07 Phase 2
NCT05781425 Recruiting
Chemotherapy-induced Peripheral Neuropathy
Odense University Hospital|Aarhus University Hospital|Sygehus Lillebaelt|University of Southern Denmark
2023-05-12 --
NCT03544281 COMPLETED
Multiple Myeloma
GlaxoSmithKline
2018-09-20 PHASE1; PHASE2
NCT04612582 UNKNOWN
Immunoglobulin Light-Chain Amyloidosis
Guangdong Provincial People's Hospital
2020-01-01 PHASE4
NCT03617484 WITHDRAWN
Mantle Cell Lymphoma
University of Michigan Rogel Cancer Center
2020-07 PHASE2
NCT04776850 WITHDRAWN
Beta Thalassemia Major; Sickle Beta 0 Thalassemia; Sickle Beta Plus Thalassemia; Sickle Beta Thalassemia; Sickle Cell Disease; Sickle Cell-SS Disease
M.D. Anderson Cancer Center
2020-12-29 EARLY_PHASE1
NCT03620903 ACTIVE_NOT_RECRUITING
Waldenstrom Macroglobulinemia
Christian Buske
2019-09-11 PHASE2
NCT04258683 WITHDRAWN
Multiple Myeloma
Canadian Myeloma Research Group
2021-02-17 PHASE2
NCT05383547 Unknown status
Bortezomib|Glomerulonephritis|MN|MPGN|FSGS|IgA Nephropathy
Ruijin Hospital
2022-08-02 Not Applicable
NCT04915248 Recruiting
Plasmablastic Lymphoma
Fondazione Italiana Linfomi - ETS|Janssen-Cilag S.p.A.
2022-07-11 Phase 2
NCT04956302 TERMINATED
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Abdullah Khan
2021-09-27 PHASE1
NCT02553460 ACTIVE_NOT_RECRUITING
Acute Lymphoblastic Leukemia
St. Jude Children's Research Hospital
2016-01-29 PHASE1; PHASE2
NCT02844322 COMPLETED
Waldenström Macroglobulinemia
Institute of Hematology & Blood Diseases Hospital, China
2016-05 PHASE4
NCT02514382 COMPLETED
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
University of Southern California
2015-08-21 PHASE1
NCT02461888 COMPLETED
Multiple Myeloma
University of Leeds
2015-12 PHASE2
NCT03130348 WITHDRAWN
Amyloidosis; Immunoglobulin Light Chain Deposition
Mayo Clinic
2018-03-15 PHASE2
NCT04277845 UNKNOWN
Multiple Myeloma
Samsung Medical Center
2020-08-06 PHASE2
NCT01208662 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Paul Richardson, MD
2010-09 PHASE3
NCT02513186 COMPLETED
Plasma Cell Myeloma
Sanofi
2015-09-30 PHASE1
NCT01554852 UNKNOWN
Multiple Myeloma
University of Leeds
2010-05 PHASE3
NCT04065789 COMPLETED
Myeloma Multiple; Myeloma, Plasma-Cell; Myeloma-Multiple; Plasma Cell Myeloma
Tel-Aviv Sourasky Medical Center
2018-05-02 PHASE2
NCT01038388 COMPLETED
Multiple Myeloma
Emory University
2010-01-15 PHASE1
NCT04656951 Recruiting
Multiple Myeloma
University of Cologne|Janssen-Cilag G.m.b.H
2021-06-01 Phase 2
NCT03416374 COMPLETED
Relapsed and/or Refractory Multiple Myeloma
Takeda
2018-02-18 PHASE4
NCT00720785 COMPLETED
Chronic Myeloid Leukemia (CML); Pancreatic Ca; Colon/Rectal Ca; Multiple Myeloma; Carcinoma, Non-Small -Cell Lung
National Heart, Lung, and Blood Institute (NHLBI)
2008-08-01 PHASE1
NCT03051841 UNKNOWN
Myeloma, Multiple
Chong Kun Dang Pharmaceutical
2017-01 PHASE1
NCT01913730 COMPLETED
Multiple Myeloma
European Myeloma Network B.V.
2013-11 PHASE2
NCT02755597 COMPLETED
Relapsed/Refractory Multiple Myeloma
AbbVie
2016-07-11 PHASE3
NCT00492050 ACTIVE_NOT_RECRUITING
Waldenstrom's Macroglobulinemia
M.D. Anderson Cancer Center
2006-08-02 PHASE2
NCT03401372 COMPLETED
Amyloidosis; Systemic
Jian Li
2018-04-21
NCT01208766 COMPLETED
Multiple Myeloma
Stichting Hemato-Oncologie voor Volwassenen Nederland
2011-01 PHASE3
NCT03345303 UNKNOWN
Intrahepatic Cholangiocarcinoma
Zhengang Yuan
2017-01 PHASE3
NCT01267812 COMPLETED
Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma
City of Hope Medical Center
2011-10-03 PHASE2
NCT00477412 COMPLETED
Mantle Cell Lymphoma
M.D. Anderson Cancer Center
2007-04-03 PHASE1; PHASE2
NCT03136653 COMPLETED
Multiple Myeloma in Relapse
Molecular Partners AG
2017-05-23 PHASE1; PHASE2
NCT02440464 COMPLETED
Multiple Myeloma
National Heart, Lung, and Blood Institute (NHLBI)
2015-08 PHASE2
NCT01849783 COMPLETED
Extramedullary Plasmacytoma; Isolated Plasmacytoma of Bone; Light Chain Deposition Disease; Primary Systemic Amyloidosis; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma
Margarida Magalhaes-Silverman
2013-04-04 PHASE2
NCT03487133 COMPLETED
Relapsed and/or Refractory Cutaneous T-cell Lymphoma
Samsung Medical Center
2017-09-19 PHASE2
NCT02541383 COMPLETED
Multiple Myeloma
Intergroupe Francophone du Myelome
2015-09 PHASE3
NCT03412565 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2018-04-26 PHASE2
NCT03515200 TERMINATED
Acute Lymphoblastic Leukemia, in Relapse; Acute Lymphoblastic Leukemia With Failed Remission
St. Jude Children's Research Hospital
2018-04-20 PHASE1
NCT03217812 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2017-11-23 PHASE3
NCT02525172 UNKNOWN
Pompe Disease
National Taiwan University Hospital
2015-08 PHASE4
NCT01453101 COMPLETED
Multiple Myeloma
Hackensack Meridian Health
2010-06-09 PHASE2
NCT03701321 WITHDRAWN
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
National Cancer Institute (NCI)
2019-01-25 PHASE1; PHASE2
NCT02626481 COMPLETED
Multiple Myeloma
University Hospital, Lille
2015-12-28 PHASE2
NCT03110562 COMPLETED
Multiple Myeloma
Karyopharm Therapeutics Inc
2017-05-24 PHASE3
NCT03201965 COMPLETED
Amyloidosis
Janssen Research & Development, LLC
2017-10-05 PHASE3
NCT01668719 COMPLETED
DS Stage I Plasma Cell Myeloma; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma
SWOG Cancer Research Network
2012-11 PHASE1; PHASE2
NCT01216683 COMPLETED
Lymphoma
ECOG-ACRIN Cancer Research Group
2011-02-09 PHASE2
NCT02605356 WITHDRAWN
Multiple Myeloma
Bayer
2016-10 PHASE1; PHASE2
NCT02219178 COMPLETED
Multiple Myeloma
Cancer Trials Ireland
2014-11 PHASE2
NCT02654990 COMPLETED
Multiple Myeloma
pharmaand GmbH
2016-04-27 PHASE2
NCT03700229 UNKNOWN
Acquired Hemophilia A
Peking Union Medical College Hospital
2018-10-10 PHASE2
NCT03234972 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2017-11-30 PHASE3
NCT02703779 COMPLETED
Multiple Myeloma
Siddhartha Ganguly
2016-03 PHASE2
NCT01833143 COMPLETED
Non-Small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
2013-04-11 PHASE2
NCT02336815 COMPLETED
Multiple Myeloma
Karyopharm Therapeutics Inc
2015-05-26 PHASE2
NCT01497093 COMPLETED
Multiple Myeloma
Celgene
2012-02-15 PHASE1
NCT01163357 COMPLETED
Autologous Hematopoietic Stem Cell Transplant Recipient; Loss of Chromosome 17p; Plasma Cell Leukemia; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
City of Hope Medical Center
2011-01-28 PHASE1
NCT01794507 COMPLETED
Relapsed/Refractory Multiple Myeloma
AbbVie
2012-11-19 PHASE1
NCT02658396 WITHDRAWN
Multiple Myeloma; Multiple Myeloma in Relapse; Refractory Multiple Myeloma
Dana-Farber Cancer Institute
PHASE1
NCT03242460 COMPLETED
Relapsed and/or refractorY Multiple Myeloma
Kosin University Gospel Hospital
2015-05-12 PHASE2
NCT02928029 TERMINATED
Multiple Myeloma
Bayer
2017-02-10 PHASE1; PHASE2
NCT01805557 COMPLETED
Diffuse Large B-cell Lymphoma Refractory; Diffuse Large B-cell Lymphoma Recurrent
Fondazione Italiana Linfomi - ETS
2013-02-04 PHASE2; PHASE3
NCT01965353 COMPLETED
Multiple Myeloma in Relapse
Dana-Farber Cancer Institute
2013-10 PHASE1
NCT01440582 COMPLETED
Myeloma
M.D. Anderson Cancer Center
2013-02-18 PHASE1
NCT02197221 COMPLETED
Multiple Myeloma
University Hospital, Toulouse
2015-01 PHASE3
NCT01788020 COMPLETED
Waldenström's Macroglobulinemia
University of Ulm
2013-11 PHASE3
NCT01965977 UNKNOWN
Diffuse Large B Cell Lymphoma
Samsung Medical Center
2015-04-08 PHASE2
NCT02559154 UNKNOWN
Multiple Myeloma
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
2010-07 PHASE4
NCT02237261 COMPLETED
Multiple Myeloma
University Hospital Heidelberg
2014-11 PHASE2
NCT02308280 COMPLETED
Multiple Myeloma; High-Risk Cancer
Maisonneuve-Rosemont Hospital
2014-11 PHASE2
NCT02955810 UNKNOWN
Multiple Myeloma
National University of Ireland, Galway, Ireland
2016-11 PHASE1
NCT02500251 COMPLETED
Renal Transplant Rejection
E. Steve Woodle
2015-06 PHASE1; PHASE2
NCT01695941 ACTIVE_NOT_RECRUITING
Recurrent B-Cell Non-Hodgkin Lymphoma; Recurrent Mantle Cell Lymphoma; Refractory B-Cell Non-Hodgkin Lymphoma; Refractory Mantle Cell Lymphoma
National Cancer Institute (NCI)
2012-08-31 PHASE1
NCT02811978 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2016-09-27 PHASE3
NCT00967369 COMPLETED
Recurrent Classic Hodgkin Lymphoma; Refractory Classic Hodgkin Lymphoma
M.D. Anderson Cancer Center
2009-08-24 PHASE2
NCT02951819 COMPLETED
Multiple Myeloma
Janssen Scientific Affairs, LLC
2016-11-09 PHASE2
NCT02497378 COMPLETED
Multiple Myeloma
Janssen Pharmaceutical K.K.
2015-07-10 PHASE1
NCT01926899 COMPLETED
Hematopoetic Stem Cell Transplant
Indiana University
2013-08-01 PHASE1
NCT02158702 UNKNOWN
Multiple Myeloma; Relapse After Use of Lenalidomide and Bortezomib
National University Hospital, Singapore
2014-11 PHASE2
NCT02206425 COMPLETED
Multiple Myeloma
Oncotherapeutics
2014-09 PHASE1; PHASE2
NCT02290431 COMPLETED
Relapse/Refractory Multiple Myeloma
Novartis Pharmaceuticals
2014-12-16 PHASE2
NCT02195479 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2014-12-09 PHASE3
NCT02208037 COMPLETED
Acute Leukemia; Chronic Myelogenous Leukemia; Myelodysplasia; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Hodgkin's Lymphoma
National Heart, Lung, and Blood Institute (NHLBI)
2014-08 PHASE2
NCT02563340 UNKNOWN
Kidney Transplantation
First Affiliated Hospital, Sun Yat-Sen University
2015-11 PHASE1; PHASE2
NCT01212952 COMPLETED
Refractory Multiple Myeloma
Mayo Clinic
2011-09 PHASE1; PHASE2
NCT01460420 COMPLETED
Hematologic Malignancies; Multiple Myeloma
European Myeloma Network B.V.
2011-11 PHASE1; PHASE2
NCT02489500 TERMINATED
AL Amyloidosis
Boston Medical Center
2015-06 PHASE3
NCT01103778 COMPLETED
Chronic Kidney Disease; IgA Nephropathy
The Rogosin Institute
2010-07 PHASE4
NCT03000634 WITHDRAWN
Multiple Myeloma
University of Arkansas
2017-04-01 PHASE2
NCT01672736 TERMINATED
Multiple Myeloma
University Health Network, Toronto
2012-09 PHASE1; PHASE2
NCT01696474 COMPLETED
Refractory Cold Agglutinin Disease
Gruppo Italiano Malattie EMatologiche dell'Adulto
2012-12 PHASE2
NCT01842074 UNKNOWN
Patients Awaiting a Living Kidney Donation
Assistance Publique - Hôpitaux de Paris
2013-03 PHASE4
NCT01592981 COMPLETED
Waldenstrom's Macroglobulinaemia
University College, London
2013-01 PHASE2
NCT01109004 COMPLETED
Multiple Myeloma
National Heart, Lung, and Blood Institute (NHLBI)
2010-05 PHASE3
NCT01470131 TERMINATED
Multiple Myeloma
AB Science
2011-05 PHASE3
NCT02893111 COMPLETED
Neuromyelitis Optica Spectrum Disorder
Tianjin Medical University General Hospital
2015-12 PHASE2
NCT01827137 COMPLETED
Multiple Myeloma
Sellas Life Sciences Group
2013-04 PHASE1; PHASE2
NCT02336386 UNKNOWN
Extramedullary Plasmacytoma
Beijing Chao Yang Hospital
2014-12 PHASE3
NCT01522872 UNKNOWN
Multiple Myeloma
Threshold Pharmaceuticals
2012-02 PHASE1; PHASE2
NCT01534260 COMPLETED
Acute Myeloid Leukemia
Hamid Sayar
2012-02-10 PHASE1; PHASE2
NCT02082405 WITHDRAWN
Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma
Case Comprehensive Cancer Center
2015-04 PHASE2
NCT02220608 COMPLETED
Multiple Myeloma
Washington University School of Medicine
2015-02-20 PHASE1
NCT02188537 COMPLETED
Myeloma
Swiss Cancer Institute
2014-12-02 PHASE2
NCT02481934 COMPLETED
Multiple Myeloma
Joaquín Martínez López, MD, PhD
2013-03 PHASE1
NCT01420926 COMPLETED
Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Therapy-Related Acute Myeloid Leukemia
National Cancer Institute (NCI)
2011-11-16 PHASE2
NCT01273844 COMPLETED
Amyloidosis
Zhi-Hong Liu, M.D.
2011-03-01
NCT00737529 COMPLETED
Mantle Cell Lymphoma
Celgene
2008-12-22 PHASE2
NCT00923247 TERMINATED
Medullary Thyroid Carcinoma
National Cancer Institute (NCI)
2009-02-19 PHASE1; PHASE2
NCT01435395 COMPLETED
Glioblastoma Multiforme
Emory University
2011-12 PHASE1
NCT01860170 COMPLETED
Hematological Malignancy
Corewell Health West
2012-04 PHASE1; PHASE2
NCT01359657 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2011-09 PHASE1
NCT01936090 COMPLETED
DS Stage I Plasma Cell Myeloma; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Mayo Clinic
2013-08 PHASE1
NCT01277016 COMPLETED
AL Amyloidosis
European Myeloma Network B.V.
2011-01 PHASE3
NCT00644228 ACTIVE_NOT_RECRUITING
DS Stage I Multiple Myeloma; DS Stage II Multiple Myeloma; DS Stage III Multiple Myeloma
National Cancer Institute (NCI)
2008-07-28 PHASE3
NCT00634179 COMPLETED
Lymphoma, B-Cell; Follicular Lymphoma
Emory University
2008-02 PHASE1; PHASE2
NCT00422799 COMPLETED
Waldenstrom's Macroglobulinemia
Dana-Farber Cancer Institute
2006-08-30 PHASE2
NCT01695330 TERMINATED
Multiple Myeloma
Oncotherapeutics
2012-05 PHASE2
NCT01485835 COMPLETED
Multiple Myeloma
Emory University
2012-01 PHASE1
NCT01208818 COMPLETED
Chronic Renal Failure With Uremic Nephropathy
Assistance Publique - Hôpitaux de Paris
2011-06 PHASE3
NCT01971658 COMPLETED
Multiple Myeloma
Nantes University Hospital
2013-10 PHASE3
NCT00931918 COMPLETED
Non-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL)
Millennium Pharmaceuticals, Inc.
2009-10 PHASE2
NCT01023308 COMPLETED
Multiple Myeloma
Novartis Pharmaceuticals
2009-12-21 PHASE3
NCT01142401 COMPLETED
Metastatic Breast Carcinoma; Stage IIIB Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7; Stage IV Breast Cancer AJCC v6 and v7
National Cancer Institute (NCI)
2010-05-26 PHASE2
NCT02268890 COMPLETED
Multiple Myeloma
Johnson & Johnson Taiwan Ltd
2014-12 PHASE4
NCT00903734 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
2009-04 PHASE1
NCT01647165 WITHDRAWN
Multiple Myeloma
National Cancer Institute (NCI)
2012-07-11 PHASE2
NCT01594242 COMPLETED
Multiple Myeloma
Abramson Cancer Center at Penn Medicine
2012-07-10 EARLY_PHASE1
NCT01349595 TERMINATED
Disorder of Transplanted Kidney
Mark Stegall
2011-12 PHASE2
NCT01090921 COMPLETED
Multiple Myeloma
Boston VA Research Institute, Inc.
2007-05 PHASE2
NCT01873157 COMPLETED
Late Rejection of Renal Transplant; Antibody-mediated Rejection
Medical University of Vienna
2013-12 PHASE2
NCT01075425 COMPLETED
Acute Lymphocytic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome; Chronic Myelogenous Leukemia
Virginia Commonwealth University
2010-05 PHASE1
NCT01495351 COMPLETED
Multiple Myeloma
AHS Cancer Control Alberta
2011-10 PHASE1
NCT02037256 COMPLETED
Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage I Small Lymphocytic Lymphoma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia
Barbara Ann Karmanos Cancer Institute
2011-07
NCT01492881 WITHDRAWN
Multiple Myeloma
UNC Lineberger Comprehensive Cancer Center
2012-04 PHASE2
NCT01255514 COMPLETED
Multiple Myeloma
Yonsei University
2008-10-30 PHASE2
NCT01381692 COMPLETED
Recurrent Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Non-Hodgkin Lymphoma; Recurrent Small Lymphocytic Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Refractory Follicular Lymphoma; Refractory Mantle Cell Lymphoma; Refractory Marginal Zone Lymphoma; Refractory Non-Hodgkin Lymphoma; Refractory Small Lymphocytic Lymphoma
National Cancer Institute (NCI)
2011-07-20 PHASE1; PHASE2
NCT01255527 UNKNOWN
Multiple Myeloma Patients Who Candidate for Autologous Peripheral Blood Stem Cell Transplantation
Yonsei University
2010-10 PHASE1; PHASE2
NCT00861250 COMPLETED
Multiple Myeloma
Tampere University Hospital
2009-03 PHASE2; PHASE3
NCT01568866 COMPLETED
Multiple Myeloma
Amgen
2012-06-20 PHASE3
NCT01226849 COMPLETED
Diffuse Large B-Cell Lymphoma
Singapore General Hospital
2010-11 PHASE1
NCT01460602 WITHDRAWN
Follicular Lymphoma; Marginal Zone Lymphoma; Mantle Cell Lymphoma
Louisiana State University Health Sciences Center Shreveport
2010-05 PHASE1; PHASE2
NCT00598169 COMPLETED
Lymphoma
AIDS Malignancy Consortium
2007-11 PHASE1
NCT01029730 COMPLETED
Lymphoma
SCRI Development Innovations, LLC
2010-03 PHASE2
NCT00081939 COMPLETED
Multiple Myeloma
University of Arkansas
2004-01 PHASE2
NCT01521533 COMPLETED
Multiple Myeloma
TME Pharma AG
2012-03 PHASE2
NCT01034553 COMPLETED
Refractory Multiple Myeloma
Mayo Clinic
2010-02 PHASE1; PHASE2
NCT00983346 TERMINATED
Cancer; Myeloma; Multiple Myeloma
University of Utah
2009-10 PHASE2
NCT01504776 COMPLETED
Mantle Cell Lymphoma
Anand Jillella
2011-04 PHASE1
NCT01602224 COMPLETED
Multiple Myeloma
Eli Lilly and Company
2012-07 PHASE2
NCT00564200 COMPLETED
Multiple Myeloma
PETHEMA Foundation
2007-11 PHASE2
NCT01484626 TERMINATED
Multiple Myeloma
Loyola University
2011-05-05 PHASE1; PHASE2
NCT03402295 COMPLETED
Multiple Myeloma; Effects of Chemotherapy
Grupo de Estudos Multicentricos em Onco-Hematologia
2009-06-15 PHASE3
NCT01365559 COMPLETED
Multiple Myeloma
Oncotherapeutics
2011-05-02 PHASE1; PHASE2
NCT01376401 COMPLETED
Multiple Myeloma
PETHEMA Foundation
2011-07 PHASE2
NCT01478048 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2011-11-30 PHASE2
NCT01000285 COMPLETED
Leukemia-Lymphoma, Adult T-Cell
Washington University School of Medicine
2010-09 PHASE1; PHASE2
NCT01127009 COMPLETED
Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia
Case Comprehensive Cancer Center
2010-07 PHASE1
NCT01053949 COMPLETED
Multiple Myeloma
University Hospital, Lille
2009-10 PHASE2
NCT01536067 TERMINATED
Waldenström Macroglobulinemia
Roswell Park Cancer Institute
2012-04 PHASE2
NCT01315873 TERMINATED
Multiple Myeloma
NYU Langone Health
2011-09 PHASE2
NCT01537861 TERMINATED
Multiple Myeloma
Washington University School of Medicine
2012-06 EARLY_PHASE1
NCT01078441 TERMINATED
Refractory Multiple Myeloma
National Cancer Institute (NCI)
2010-09 PHASE2
NCT01083602 COMPLETED
Relapsed and Bortezomib Refractory Multiple Myeloma; Refractory Multiple Myeloma; Multiple Myeloma in Relapse
Novartis Pharmaceuticals
2010-06 PHASE2
NCT01125293 TERMINATED
Waldenstrom's Macroglobulinemia
Dana-Farber Cancer Institute
2010-04 PHASE1; PHASE2
NCT00784823 COMPLETED
Multiple Myeloma
Hackensack Meridian Health
2007-01 PHASE1; PHASE2
NCT02808091 TERMINATED
Extranodal NK-T-CELL LYMPHOMA
National Cancer Centre, Singapore
2011-03 PHASE2
NCT01063907 COMPLETED
Multiple Myeloma
Kyowa Kirin Co., Ltd.
2010-03 PHASE1; PHASE2
NCT01783522 TERMINATED
Chemotherapeutic Agent Toxicity; Multiple Myeloma; Peripheral Neuropathy
Beth Faiman
2013-02 PHASE2
NCT00711828 COMPLETED
Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Nodal Marginal Zone Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia
Mayo Clinic
2008-08 PHASE2
NCT00532389 COMPLETED
Multiple Myeloma
Novartis Pharmaceuticals
2007-10 PHASE1
NCT01322776 UNKNOWN
Mantle Cell Lymphoma Recurrent
Sun Yat-sen University
2011-03 PHASE1; PHASE2
NCT01328236 UNKNOWN
Plasma Cell Leukemia; Multiple Myeloma
Clinical Service, China
2010-09 PHASE2
NCT00548717 TERMINATED
Graft-vs-Host Disease
Dana-Farber Cancer Institute
2007-10 PHASE2
NCT02467010 COMPLETED
Multiple Myeloma
University Medical Center Groningen
2008-09 PHASE2
NCT00714246 TERMINATED
Non Small Cell Lung Cancer
Milton S. Hershey Medical Center
2008-10 PHASE1
NCT00972959 COMPLETED
Multiple Myeloma
University of Athens
2009-07 PHASE2
NCT01397591 TERMINATED
Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma
OHSU Knight Cancer Institute
2011-10 PHASE2
NCT00410423 COMPLETED
Relapsed Acute Leukemia; Refractory Acute Leukemia
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2006-01 PHASE1; PHASE2
NCT01633645 COMPLETED
Non Small Cell Lung Cancer; Metastatic
University Hospital of Crete
2009-06 PHASE2
NCT00108069 COMPLETED
Glioma
National Cancer Institute (NCI)
2005-04 PHASE2
NCT00507416 COMPLETED
Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2007-06 PHASE3
NCT00869323 TERMINATED
Lymphoproliferative Disorder
Masonic Cancer Center, University of Minnesota
2009-03 PHASE2
NCT01078961 COMPLETED
Melanoma
Massachusetts General Hospital
2010-09 PHASE1
NCT01323920 COMPLETED
Leukemia; Lymphoma; Myelodysplastic Syndrome
Dana-Farber Cancer Institute
2011-05 PHASE2
NCT01312818 TERMINATED
Acute Lymphoblastic Leukemia
Masonic Cancer Center, University of Minnesota
2011-06 PHASE2
NCT00689507 COMPLETED
Multiple Myeloma
Applied Molecular Evolution
2008-03 PHASE1
NCT00813150 COMPLETED
Multiple Myeloma
Janssen-Cilag G.m.b.H
2009-01 PHASE3
NCT01171092 COMPLETED
Malignant Lymphoma, Stem Cell Type; Autologous Transplant
University of Kansas Medical Center
2010-09 EARLY_PHASE1
NCT00084747 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Jonsson Comprehensive Cancer Center
2004-06 PHASE1; PHASE2
NCT00376961 COMPLETED
Lymphoma
SWOG Cancer Research Network
2006-08 PHASE2
NCT00771875 COMPLETED
Graft Rejection
University of Cincinnati
2008-09 PHASE2
NCT00691704 COMPLETED
Multiple Myeloma
Cristina Gasparetto
2008-08 PHASE2
NCT00750815 COMPLETED
Multiple Myeloma
H. Lee Moffitt Cancer Center and Research Institute
2008-09 PHASE1; PHASE2
NCT00590603 TERMINATED
Multiple Myeloma
Duke University
2008-07 PHASE1
NCT01078454 COMPLETED
Light Chain Deposition Disease; Primary Systemic Amyloidosis
National Cancer Institute (NCI)
2010-11 PHASE3
NCT00581776 COMPLETED
Mantle Cell Lymphoma
University of Wisconsin, Madison
2005-05 PHASE2
NCT00510887 TERMINATED
Lymphoma, Follicular
Duke University
2007-01 PHASE2
NCT00428545 COMPLETED
Advanced Malignancy; Lymphoma; Myeloma; Solid Tumors
M.D. Anderson Cancer Center
2007-01 PHASE1
NCT00798720 COMPLETED
Carcinoma, Non Small Cell Lung
University of Wisconsin, Madison
2008-12 PHASE2
NCT00082784 COMPLETED
Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Nodal Marginal Zone Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Refractory Plasma Cell Myeloma; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia
National Cancer Institute (NCI)
2004-03 PHASE1
NCT00378209 COMPLETED
Multiple Myeloma
Dana-Farber Cancer Institute
2006-08 PHASE2
NCT00839956 COMPLETED
DS Stage I Plasma Cell Myeloma; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma
Fred Hutchinson Cancer Center
2009-02 PHASE2
NCT01164709 COMPLETED
Leukemia; Lymphoma; Mature T-cell and Nk-cell Neoplasms; Multiple Myeloma and Plasma Cell Neoplasm
Swiss Cancer Institute
2010-07 PHASE1
NCT00644696 COMPLETED
Neuroblastoma
University of Michigan Rogel Cancer Center
2008-04 PHASE1
NCT00439361 COMPLETED
Hodgkin Lymphoma; Lymphoma
M.D. Anderson Cancer Center
2007-02 PHASE1
NCT01249690 UNKNOWN
Multiple Myeloma
Second Military Medical University
2010-06 PHASE4
NCT00383474 COMPLETED
Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Adult Erythroleukemia; Adult Pure Erythroid Leukemia; Blastic Phase; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Disease; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI)
2006-08 PHASE1
NCT00884546 COMPLETED
Advanced Cancer, Various, NOS
Bristol-Myers Squibb
2009-07 PHASE1
NCT00307086 COMPLETED
Multiple Myeloma; Plasma Cell Leukemia
H. Lee Moffitt Cancer Center and Research Institute
2005-06 PHASE2
NCT00815919 COMPLETED
Chronic Graft Versus Host Disease
Dana-Farber Cancer Institute
2008-12 PHASE2
NCT00544284 COMPLETED
Brain and Central Nervous System Tumors; Lymphoma; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
City of Hope Medical Center
2005-01 PHASE1
NCT00744354 TERMINATED
Multiple Myeloma and Plasma Cell Neoplasm
UNC Lineberger Comprehensive Cancer Center
2008-10 PHASE1
NCT00515138 TERMINATED
Lymphoma, B-Cell
University of California, San Francisco
2007-05 EARLY_PHASE1
NCT00103259 COMPLETED
Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer
National Cancer Institute (NCI)
2005-07 PHASE2
NCT02353468 TERMINATED
Refractory Plasma Cell Myeloma
University of Colorado, Denver
2009-12 PHASE2
NCT00718601 COMPLETED
Multiple Myeloma
Geron Corporation
2008-07 PHASE1
NCT00773747 COMPLETED
Multiple Myeloma
Merck Sharp & Dohme LLC
2008-12-01 PHASE3
NCT01055301 WITHDRAWN
Multiple Myeloma; Plasma Cell Myeloma
SWOG Cancer Research Network
2011-07 PHASE2
NCT01300793 TERMINATED
Non-Hodgkin's Lymphoma; B-cell Lymphoma
University of California, San Francisco
2007-05 PHASE1
NCT00920855 COMPLETED
Multiple Myeloma
Cephalon
2009-06 PHASE1; PHASE2
NCT00538187 TERMINATED
Adult Non-Hodgkin Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma
National Cancer Institute (NCI)
2007-12 PHASE1
NCT00458705 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Memorial Sloan Kettering Cancer Center
2006-11 PHASE2
NCT01072773 COMPLETED
Primary Systemic Amyloidosis
Mayo Clinic
2010-03 PHASE2
NCT00872521 COMPLETED
Multiple Myeloma
Janssen-Cilag Pty Ltd
2009-01 PHASE2
NCT00366106 TERMINATED
Multiple Myeloma
Accelerated Community Oncology Research Network
2006-07 PHASE2
NCT00440726 COMPLETED
Acute Lymphoblastic Leukemia
Therapeutic Advances in Childhood Leukemia Consortium
2006-08-04 PHASE1; PHASE2
NCT00290706 TERMINATED
Lymphoma
Northwestern University
2006-04-07 PHASE1; PHASE2
NCT00560352 TERMINATED
Multiple Myeloma
Bristol-Myers Squibb
2008-02 PHASE1
NCT00148317 COMPLETED
Multiple Myeloma
Weill Medical College of Cornell University
2005-06 PHASE2
NCT00483262 COMPLETED
Multiple Myeloma
Dana-Farber Cancer Institute
2007-05 PHASE1; PHASE2
NCT00581919 COMPLETED
Multiple Myeloma
University of Wisconsin, Madison
2004-02 PHASE2
NCT00772668 TERMINATED
Lymphoma; Follicular Lymphoma; Marginal Zone Lymphoma
University of Miami
2009-09-25
NCT00288028 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Barbara Ann Karmanos Cancer Institute
2005-07 PHASE1
NCT00287872 COMPLETED
Multiple Myeloma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2004-09 PHASE2
NCT00262873 COMPLETED
Myelodysplastic Syndromes
University of Rochester
2005-05 PHASE2
NCT00315757 COMPLETED
Multiple Myeloma
Human Genome Sciences Inc.
2006-05 PHASE2
NCT01462773 COMPLETED
Melanoma
Ohio State University Comprehensive Cancer Center
2006-01 PHASE1
NCT00507442 COMPLETED
Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2007-08 PHASE1; PHASE2
NCT00520767 COMPLETED
Primary Systemic Amyloidosis; Light Chain Deposition Disease
Barbara Ann Karmanos Cancer Institute
2007-09 PHASE2
NCT01445405 COMPLETED
Carcinoma, Squamous; Head and Neck Cancer; Oral Cancer; Laryngeal Cancer; Pharyngeal Cancer
National Cancer Institute (NCI)
2008-02-05 PHASE1
NCT00411905 COMPLETED
Myelodysplastic Syndromes
Groupe Francophone des Myelodysplasies
2006-06-01 PHASE1; PHASE2
NCT00369226 COMPLETED
Hematologic Malignancies
Dana-Farber Cancer Institute
2006-08 PHASE1; PHASE2
NCT00742404 UNKNOWN
Multiple Myeloma and Plasma Cell Neoplasm
Oncotherapeutics
2008-07 PHASE2
NCT00641706 COMPLETED
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
2008-07 PHASE2
NCT00791011 COMPLETED
Hodgkin's Lymphoma; Low Grade Lymphoma; Lymphoma; Mantle Cell Lymphoma; Non-Hodgkin's Lymphoma; Diffuse Large Cell Lymphoma
Amgen
2008-02 PHASE1
NCT00093704 TERMINATED
Lymphoma; Lymphoproliferative Disorder
Jonsson Comprehensive Cancer Center
2005-03 PHASE1
NCT00362882 COMPLETED
Non-small Cell Lung Cancer; Recurrent Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2006-07 PHASE2
NCT00720148 COMPLETED
Solid Tumors
Emory University
2008-02 PHASE1
NCT00372905 TERMINATED
Lymphoma
Northwestern University
2007-07-24 PHASE1; PHASE2
NCT00329589 COMPLETED
Brain Cancer; Head and Neck Cancer; Cervix Cancer; Central Nervous System Neoplasms
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2005-09 PHASE1
NCT00312845 COMPLETED
Non-Hodgkin's Lymphoma
Millennium Pharmaceuticals, Inc.
2006-03 PHASE3
NCT00104871 COMPLETED
Insular Thyroid Cancer; Recurrent Thyroid Cancer; Stage II Follicular Thyroid Cancer; Stage II Papillary Thyroid Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Papillary Thyroid Cancer
National Cancer Institute (NCI)
2004-12 PHASE2
NCT00303797 COMPLETED
Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Stage III Multiple Myeloma; Stage IV Chronic Lymphocytic Leukemia; Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
2005-12 PHASE1
NCT00723658 WITHDRAWN
Lymphoma
SWOG Cancer Research Network
2008-09 PHASE2
NCT00458913 COMPLETED
Malignant Mesothelioma
European Organisation for Research and Treatment of Cancer - EORTC
2007-02 PHASE2
NCT00151320 COMPLETED
Non-Hodgkin's Lymphoma
Weill Medical College of Cornell University
2004-01 PHASE1; PHASE2
NCT00546780 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2008-02 PHASE3
NCT00608907 COMPLETED
Multiple Myeloma; Non-Hodgkin's Lymphoma
Millennium Pharmaceuticals, Inc.
2007-09 PHASE1
NCT00096005 TERMINATED
Adult Grade III Lymphomatoid Granulomatosis; AIDS-related Peripheral/Systemic Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
National Cancer Institute (NCI)
2004-11 PHASE1
NCT00536575 COMPLETED
Multiple Myeloma
SCRI Development Innovations, LLC
2007-11 PHASE1; PHASE2
NCT00348985 COMPLETED
Adult Grade III Lymphomatoid Granulomatosis; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
National Cancer Institute (NCI)
2006-03 PHASE1
NCT00023712 COMPLETED
Primary Peritoneal Cavity Cancer; Recurrent Ovarian Epithelial Cancer
National Cancer Institute (NCI)
2001-11-05 PHASE2
NCT00061932 COMPLETED
Adenocarcinoma of the Gastroesophageal Junction; Diffuse Adenocarcinoma of the Stomach; Intestinal Adenocarcinoma of the Stomach; Mixed Adenocarcinoma of the Stomach; Recurrent Gastric Cancer; Stage IIIB Gastric Cancer; Stage IIIC Gastric Cancer; Stage IV Gastric Cancer
National Cancer Institute (NCI)
2003-04 PHASE2
NCT00389701 UNKNOWN
Multiple Myeloma and Plasma Cell Neoplasm
Sparrow Regional Cancer Center
2006-03 PHASE2
NCT00513877 COMPLETED
Malignant Mesothelioma
Cancer Trials Ireland
2006-05 PHASE2
NCT00718640 TERMINATED
Multiple Myeloma
Janssen-Ortho Inc., Canada
2007-10 PHASE2
NCT00473590 COMPLETED
Multiple Myeloma
Genentech, Inc.
2007-06 PHASE2
NCT00793650 TERMINATED
Cancer; Multiple Myeloma
Emory University
2005-05 PHASE1; PHASE2
NCT00054483 COMPLETED
Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
National Cancer Institute (NCI)
2003-01 PHASE1
NCT00611325 COMPLETED
Glioblastoma; Gliosarcoma
Duke University
2008-05 PHASE2
NCT00374699 COMPLETED
Peripheral T-Cell Lymphomas; Non-Hodgkin Lymphoma
Samsung Medical Center
2006-04 PHASE1; PHASE2
NCT00622674 COMPLETED
Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Kidney Cancer; Lung Cancer; Pancreatic Cancer; Sarcoma; Unspecified Adult Solid Tumor, Protocol Specific
Masonic Cancer Center, University of Minnesota
2005-11 PHASE1
NCT00276614 COMPLETED
Kidney Cancer
Jonsson Comprehensive Cancer Center
2006-04 PHASE2
NCT00547534 COMPLETED
Non-Hodgkin's Lymphoma
University of Rochester
2007-10 PHASE2
NCT00833560 COMPLETED
Multiple Myeloma
Janssen-Cilag G.m.b.H
2006-03 PHASE2
NCT00814541 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Cancer Trials Ireland
2005-12 PHASE2
NCT00508209 UNKNOWN
Multiple Myeloma
Nordic Myeloma Study Group
2007-07 PHASE2
NCT00201877 COMPLETED
Non-Hodgkin's Lymphoma; Mantle Cell Lymphoma
Ohio State University Comprehensive Cancer Center
2004-12 PHASE2
NCT00417911 COMPLETED
Multiple Myeloma
Nordic Myeloma Study Group
2005-12 PHASE3
NCT00609817 TERMINATED
Multiple Myeloma
La Jolla Pharmaceutical Company
2008-05 PHASE1
NCT00577668 WITHDRAWN
Multiple Myeloma
University of Arkansas
2007-04 PHASE2
NCT00531453 COMPLETED
Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2007-10 PHASE2
NCT00407303 COMPLETED
Mantle-Cell Lymphoma
Gemin X
2006-10 PHASE1; PHASE2
NCT00514371 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2007-08 PHASE2; PHASE3
NCT00426855 COMPLETED
Lymphoma, Non-Hodgkin
Peter Moosmann
2007-01 PHASE1; PHASE2
NCT00030368 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
2001-11 PHASE1
NCT00464178 TERMINATED
Multiple Myeloma
Hackensack Meridian Health
2007-04 PHASE2
NCT00657553 TERMINATED
Multiple Myeloma
University of Arkansas
2008-02 PHASE3
NCT00609167 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Mayo Clinic
2006-12 PHASE2
NCT00789256 COMPLETED
Acute Myelogenous Leukemia; Myelodysplastic Syndromes
Dartmouth-Hitchcock Medical Center
2004-09
NCT00437086 COMPLETED
Chronic Myeloproliferative Disorders; Leukemia
Mayo Clinic
2005-09 EARLY_PHASE1
NCT00280176 COMPLETED
Colorectal Cancer
UNC Lineberger Comprehensive Cancer Center
2003-04 PHASE1
NCT00985907 TERMINATED
Multiple Myeloma; Patient Participation
University of California, San Francisco
2004-10-28 PHASE1; PHASE2
NCT00382954 COMPLETED
Acute Myelogenous Leukemia
University of Kentucky
2004-02 PHASE1
NCT00352742 TERMINATED
Multiple Myeloma
Attenuon
2006-06 PHASE1; PHASE2
NCT00408928 COMPLETED
Graft-versus-Host Disease
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
2005-11 PHASE2
NCT00479167 TERMINATED
Follicular Lymphoma
Rush University Medical Center
2007-05 PHASE2
NCT00085410 TERMINATED
Adenocarcinoma of the Extrahepatic Bile Duct; Adenocarcinoma of the Gallbladder; Advanced Adult Primary Liver Cancer; Gastrointestinal Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
National Cancer Institute (NCI)
2004-01 PHASE2
NCT00573391 TERMINATED
Multiple Myeloma
University of Arkansas
2006-08 PHASE3
NCT00316940 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Oncotherapeutics
2005-12 PHASE1
NCT00124579 TERMINATED
Multiple Myeloma
SWOG Cancer Research Network
2005-08 PHASE2
NCT00636311 COMPLETED
Hodgkin Disease
Istituto Clinico Humanitas
2008-02 PHASE2
NCT01801436 COMPLETED
Multiple Myeloma
Johnson & Johnson Taiwan Ltd
2006-12 PHASE3
NCT00511069 COMPLETED
Leukemia
University of Bologna
2006-07 PHASE2
NCT00734149 COMPLETED
Multiple Myeloma
Duke University
2004-07 PHASE2
NCT00478075 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Mayo Clinic
2005-09 PHASE1; PHASE2
NCT00388089 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
2004-12 PHASE1
NCT00509379 COMPLETED
Lymphoma; Non-Hodgkin Lymphoma
Gruppo Italiano Multiregionale per lo studio dei Linfomi e delle Leucemie
2006-09 PHASE2
NCT00052689 COMPLETED
Duct Cell Adenocarcinoma of the Pancreas; Stage IV Pancreatic Cancer
National Cancer Institute (NCI)
2002-12 PHASE2
NCT01902862 TERMINATED
Lymphoma, Follicular
Janssen-Cilag G.m.b.H
2006-02 PHASE2
NCT00504634 COMPLETED
Multiple Myeloma
M.D. Anderson Cancer Center
2004-01 PHASE2
NCT00075751 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2004-01 PHASE2
NCT00291538 COMPLETED
Multiple Myeloma
Nantes University Hospital
2006-02 PHASE1
NCT00117351 TERMINATED
Carcinoma, Non-Small-Cell Lung; Adenocarcinoma, Bronchiolo-Alveolar
Millennium Pharmaceuticals, Inc.
2005-04 PHASE2
NCT00006773 TERMINATED
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
National Cancer Institute (NCI)
2001-05 PHASE1
NCT00346645 TERMINATED
STAGE IIIB OR IV NON-SMALL CELL LUNG CANCER
Gustave Roussy, Cancer Campus, Grand Paris
2006-06 PHASE2
NCT00411593 WITHDRAWN
Lung Cancer
M.D. Anderson Cancer Center
2006-11 PHASE1; PHASE2
NCT00561743 COMPLETED
Multiple Myeloma
Janssen-Ortho Inc., Canada
2005-11 PHASE2
NCT00059618 COMPLETED
Ovarian Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer
M.D. Anderson Cancer Center
2003-04 PHASE1
NCT00082966 COMPLETED
Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma
National Cancer Institute (NCI)
2004-03 PHASE2
NCT00250926 COMPLETED
Waldenstrom's Macroglobulinemia
Dana-Farber Cancer Institute
2005-10 PHASE2
NCT00257114 COMPLETED
Multiple Myeloma
Millennium Pharmaceuticals, Inc.
PHASE4
NCT00098982 COMPLETED
Colorectal Cancer
European Organisation for Research and Treatment of Cancer - EORTC
2004-09 PHASE1
NCT00389805 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
2005-03 PHASE1; PHASE2
NCT00129207 COMPLETED
Tumors
Millennium Pharmaceuticals, Inc.
PHASE1
NCT00085696 COMPLETED
B-Cell Lymphoma; Follicular Lymphoma; Marginal Lymphoma
Millennium Pharmaceuticals, Inc.
2004-05 PHASE2
NCT00028587 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
2001-12 PHASE1
NCT00040768 TERMINATED
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2002-04 PHASE2
NCT00077467 COMPLETED
Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Promyelocytic Leukemia (M3); Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia
National Cancer Institute (NCI)
2004-01 PHASE1
NCT00045695 COMPLETED
Lymphoma
NCIC Clinical Trials Group
2002-08 PHASE2
NCT00068484 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
2003-07 PHASE1
NCT00093028 COMPLETED
Multiple Myeloma
University of Arkansas
2004-01 PHASE3
NCT00021216 COMPLETED
Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
2001-11 PHASE1
NCT00193232 COMPLETED
Prostate Cancer
SCRI Development Innovations, LLC
2004-05 PHASE2
NCT00103103 TERMINATED
Gastric Cancer
California Cancer Consortium
2005-03 PHASE2
NCT00030875 COMPLETED
Lymphoma
NCIC Clinical Trials Group
2002-11-19 PHASE2
NCT00066508 COMPLETED
Lymphoma
Jonsson Comprehensive Cancer Center
2003-05 PHASE2
NCT00063726 COMPLETED
Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2002-04 PHASE3
NCT00023881 TERMINATED
Leukemia
M.D. Anderson Cancer Center
2001-07-02 PHASE2
NCT00064610 COMPLETED
Prostatic Neoplasms
Millennium Pharmaceuticals, Inc.
2002-12 PHASE1; PHASE2
NCT00051974 COMPLETED
Non-Small Cell Lung Cancer
Millennium Pharmaceuticals, Inc.
2002-12 PHASE2
NCT00025584 COMPLETED
Recurrent Breast Cancer; Stage IV Breast Cancer
National Cancer Institute (NCI)
2001-08 PHASE2
NCT00064012 COMPLETED
Lung Cancer
University of Wisconsin, Madison
2003-05 PHASE2
NCT00027716 COMPLETED
Sarcoma
Memorial Sloan Kettering Cancer Center
2001-10 PHASE2
NCT00052338 COMPLETED
Malignant Pleural Effusion; Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
National Cancer Institute (NCI)
2002-09 PHASE1
NCT00017329 COMPLETED
Kidney Cancer
Memorial Sloan Kettering Cancer Center
2001-04 PHASE2
NCT00023855 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
University of Wisconsin, Madison
2001-06 PHASE1
NCT00006098 COMPLETED
Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center
2000-04 PHASE1
NCT00004002 COMPLETED
Lymphoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
NYU Langone Health
1999-07 PHASE1
NCT00261612 UNKNOWN
Lymphoma, Mantle-Cell
Medical University of Vienna
2005-01 PHASE2
NCT00358020 COMPLETED
Multiple Myeloma
University of Turin, Italy
2004-11 PHASE2
NCT00265928 TERMINATED
Lymphoma
University of Virginia
PHASE2
NCT00095680 COMPLETED
Multiple Myeloma
Scios, Inc.
2004-11 PHASE2
NCT00148018 TERMINATED
Hodgkin Disease
University of Cologne
2005-03 PHASE2
NCT00068289 COMPLETED
Lung Cancer
SWOG Cancer Research Network
2003-09 PHASE2
NCT00373906 COMPLETED
MALT Lymphoma
Medical University of Vienna
PHASE2
NCT00216697 COMPLETED
Multiple Myeloma
Janssen Pharmaceutical K.K.
2005-03 PHASE2
NCT00217503 COMPLETED
Lymphoma
National Cancer Institute (NCI)
2005-07 PHASE2
NCT00995059 WITHDRAWN
Multiple Myeloma; Refractory Multiple Myeloma
Mayo Clinic
PHASE1; PHASE2
NCT00028912 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Memorial Sloan Kettering Cancer Center
2001-11 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-06-18)

Check the Bortezomib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Bortezomib selectively binds and inhibits the 20S subunit of the cellular proteasome, thereby blocking the ubiquitin-proteasome pathway and suppressing downstream NF-κB signaling. This proteasomal blockade induces cell-cycle arrest and triggers apoptotic cascades, driving clinical responses and tumor suppression in trial-evaluated indications such as multiple myeloma and mantle cell lymphoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.