CAS No. 179324-69-7
Batch:
Purity:99.97
Chemical Structure
Check the
Bortezomib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid | |
|---|---|---|
| CAS Number | 179324-69-7 | |
| Molecular Formula |
C19H25BN4O4 |
|
| Molecular Weight (MW) | 384.24 | |
| SMILES | B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O | |
| InChIKey | GXJABQQUPOEUTA-RDJZCZTQSA-N |
Bortezomib is a potent 20S proteasome inhibitor with a Ki of. It selectively inhibits proteasomal catalytic activity, disrupting protein degradation via the ubiquitin-proteasome pathway. This targeted inhibition downregulates NF-κB signaling, impairs the clearance of misfolded or regulatory proteins, and induces ERK phosphorylation, ultimately driving cell cycle arrest and apoptosis in tumor cells. [1][2]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
77 mg/mL
(200.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(197.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(197.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(197.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- Bortezomib Working Concentration | Cell Culture | Treatment
- Bortezomib Solubility in DMSO
- Bortezomib Storage
- Bortezomib Stability
- Bortezomib Combination Database
- Bortezomib Molecular Weight
- Bortezomib SMILES
- Bortezomib Chemical Structure (2D and 3D)
- Bortezomib IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.