BI 2536: Mechanism of Action

BI 2536 MOA:Targeting PLK1/Cell Cycle Pathway for Oncology Research

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BI 2536 is a potent, ATP-competitive PLK1 inhibitor. It affects Wnt/β-catenin and MEK/ERK signaling by binding to the kinase ATP-binding site, effectively inducing G2/M cell cycle arrest and apoptosis, and inhibiting cancer cell proliferation.

Primary Applications and Mechanism of Action