CAS No. 755038-02-9
Batch:
Purity:99.87
Chemical Structure
Check the
BI 2536
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | |
|---|---|---|
| CAS Number | 755038-02-9 | |
| Molecular Formula |
C28H39N7O3 |
|
| Molecular Weight (MW) | 521.66 | |
| SMILES | CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C | |
| InChIKey | XQVVPGYIWAGRNI-JOCHJYFZSA-N |
Biological Activity
BI 2536 is a small-molecule inhibitor of Polo-like kinase 1 (Plk1) with an IC50 of, while also targeting Plk2 and Plk3. Selective Plk1 inhibition disrupts cell cycle progression during mitosis, leading to mitotic arrest, failure of cytokinesis, and induction of apoptosis in diverse tumor cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(191.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| Ethanol | 100 mg/mL |
| DMSO |
21 mg/mL
(40.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
100 mg/mL
(191.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(191.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- BI 2536 Mechanism of Action: PLK1 Inhibition in Cancer Cell Research
- BI 2536 Clinical Trials
- BI 2536 Working Concentration | Cell Culture | Treatment
- BI 2536 Solubility in DMSO
- BI 2536 Stock Solution
- BI 2536 Storage
- BI 2536 Stability
- BI 2536 Combination Database
- BI 2536 Molecular Weight
- BI 2536 SMILES
- BI 2536 Chemical Structure (2D and 3D)
- BI 2536 IC50 for Cell-based and Cell-free Assays
- BI 2536 Sigma (SML4229)? Try a better option.
- BI 2536 MedChemExpress (HY-50698)? Try a better option.
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- BI 2536 CST (26744)? Try a better option.
- BI 2536 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.