BI 2536 is a potent, ATP-competitive PLK1 inhibitor. It affects Wnt/β-catenin and MEK/ERK signaling by binding to the kinase ATP-binding site, effectively inducing G2/M cell cycle arrest and apoptosis, and inhibiting cancer cell proliferation.
Comprehensive IC50 Values for BI 2536 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
BI 2536 is a potent, ATP-competitive PLK1 inhibitor. It affects Wnt/β-catenin and MEK/ERK signaling by binding to the kinase ATP-binding site, effectively inducing G2/M cell cycle arrest and apoptosis, and inhibiting cancer cell proliferation.