CAS No. 4707-32-8
Batch:
Purity:99.98
Chemical Structure
Check the
Beta-Lapachone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione | |
|---|---|---|
| CAS Number | 4707-32-8 | |
| Molecular Formula |
C15H14O3 |
|
| Molecular Weight (MW) | 242.27 | |
| SMILES | CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C | |
| InChIKey | QZPQTZZNNJUOLS-UHFFFAOYSA-N |
Beta-Lapachone is a selective DNA topoisomerase I inhibitor that exhibits no inhibitory activity against DNA topoisomerase II or ligase. The compound interferes with DNA replication and induces topoisomerase I-mediated DNA cleavage. Bioactivation triggers intracellular reactive oxygen species accumulation, causing DNA damage, PARP1 hyperactivation, cellular energy depletion, and apoptotic cell death in various cancer cell lines.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
33 mg/mL
(136.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
| DMSO |
48 mg/mL
(198.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.