CAS No. 1557267-42-1

Batch: Purity:99.35
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Avitinib (Abivertinib) Chemical Structure
Chemical Structure
Check the Avitinib (Abivertinib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
CAS Number 1557267-42-1
Molecular Formula

C26H26FN7O2
Molecular Weight (MW) 487.53
SMILES CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F
InChIKey UOFYSRZSLXWIQB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Avitinib (Abivertinib) is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) inhibitor of EGFR L858R/T790M (IC50 of 0.18 nM) and wild-type EGFR (IC50 of 7.68 nM), showing nearly 43-fold selectivity for the double mutant. By suppressing mutant EGFR phosphorylation, it blocks downstream AKT and MAPK signaling pathways, leading to inhibited cell proliferation and antitumor activity in EGFR-mutant non-small cell lung cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 97 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.