ART558 is a potent, specific DNA polymerase theta (Pol θ) inhibitor. It affects DNA damage repair signaling by increasing Pol θ residence time at damage sites and blocking theta-mediated end joining, effectively radiosensitizing tumor cells and promoting apoptosis in BRCA-deficient cells.
ART558: Mechanism of Action
ART558 MOA：Targeting Polθ/Theta-Mediated End Joining for HR-Deficient Cancer Therapy