ART558 is a potent, specific DNA polymerase theta (Pol θ) inhibitor. It affects DNA damage repair signaling by increasing Pol θ residence time at damage sites and blocking theta-mediated end joining, effectively radiosensitizing tumor cells and promoting apoptosis in BRCA-deficient cells.
ART558 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for ART558 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.