For research use only. Not for use in humans.

Anti-TLR3 / CD283 (CNTO5429)

Synonyms: null Cat.No.A2696

Anti-TLR3 / CD283 (CNTO5429) is a novel antibody that binds to the extracellular domain of TLR3 and inhibit poly(I:C)-induced inflammation. MW: 145.3 KD.

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Cited in Nature Medicine for its top-tier quality
SDS
Datasheet

Specificity

Name	Citation	TLR7	TLR8	TLR9	TLR4	TLR2	TLR3	TLR1	Others
Enpatoran Hydrochloride	0	++++	+++
CU-CPT-8m	1		+++
CU-CPT9a	2		++++
MD2-IN-1	3				+
CU-CPT22	9					++		++
Okanin	0				✔				NF-κB
AMG-9810	1					✔			hTRPV1,rTRPV1
TLR4-IN-C34	7				✔
E6446	5	✔							DNA-TLR9
TLR2-IN-C29	21					✔
MD2-TLR4-IN-1	0				✔				IL-6,TNF-α
IAXO-102	0				✔				NF-κB,MAPK
E6446 Dihydrochloride	4			✔
Resatorvid (TAK-242)	63				✔				IL-6,NO,TNF-α
Ginsenoside Rb1	4						✔		IFN-β,TNF-α,NF-κB

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-TLR3 / CD283 (CNTO5429) is a novel antibody that binds to the extracellular domain of TLR3 and inhibit poly(I:C)-induced inflammation. MW: 145.3 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/21092943/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	145.3
Isotype	Human IgG2SA
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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