CAS No. 1360460-82-7
Batch:
Purity:99.93
Chemical Structure
Check the
Anlotinib (AL3818) Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxymethyl]cyclopropan-1-amine;dihydrochloride | |
|---|---|---|
| CAS Number | 1360460-82-7 | |
| Molecular Formula |
C23H22FN3O3.2HCl |
|
| Molecular Weight (MW) | 480.36 | |
| SMILES | CC1=CC2=C(N1)C=CC(=C2F)OC3=C4C=C(C(=CC4=NC=C3)OCC5(CC5)N)OC.Cl.Cl | |
| InChIKey | UUAKQNIPIXQZFN-UHFFFAOYSA-N |
Anlotinib (AL3818) Dihydrochloride is a receptor tyrosine kinase inhibitor targeting VEGFR2 with an IC50 of less than 1 nM. By suppressing VEGFR2 phosphorylation and downstream signaling through the AKT and ERK pathways, it inhibits vascular endothelial cell proliferation, migration, and tube formation. Consequently, this target blockade suppresses tumor angiogenesis and restricts tumor growth in multiple preclinical cancer models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 96 mg/mL |
| DMSO |
48 mg/mL
(99.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
| DMSO |
96 mg/mL
(199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 96 mg/mL |
| Ethanol | Insoluble |
| DMSO |
96 mg/mL
(199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 96 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Anlotinib (AL3818) Dihydrochloride Clinical Trials
- Anlotinib (AL3818) Dihydrochloride Solubility in DMSO
- Anlotinib (AL3818) Dihydrochloride Stock Solution
- Anlotinib (AL3818) Dihydrochloride Storage
- Anlotinib (AL3818) Dihydrochloride Stability
- Anlotinib (AL3818) Dihydrochloride Molecular Weight
- Anlotinib (AL3818) Dihydrochloride SMILES
- Anlotinib (AL3818) Dihydrochloride Chemical Structure (2D and 3D)
- Anlotinib (AL3818) Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.