CAS No. 1937-19-5

Batch: Purity:98.19
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Aminoguanidine hydrochloride Chemical Structure
Chemical Structure
Check the Aminoguanidine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-aminoguanidine;hydrochloride
CAS Number 1937-19-5
Molecular Formula

CH6N4.HCl
Molecular Weight (MW) 110.55
SMILES C(=NN)(N)N.Cl
InChIKey UBDZFAGVPPMTIT-UHFFFAOYSA-N

Ordering Information

Biological Activity

Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor that prevents the accumulation of advanced glycation end products (AGEs). By nucleophilically trapping reactive dicarbonyl intermediates such as 3-deoxyglucosone and methylglyoxal, it blocks protein cross-linking and retards the progression of diabetic microvascular damage. Consequently, aminoguanidine mitigates vascular stiffness, oxidative stress, and inflammatory tissue injury associated with chronic hyperglycemia. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 22 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 22 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.