Target Selectivity of Alpelisib (BYL719)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| PIK3CA | 5 nM | Biochemical assay (Furet et al. 2013) | PMC6236629 |
| PIK3CG | 250 nM | Biochemical assay (Furet et al. 2013) | PMC6236629 |
| PIK3CD | 290 nM | Biochemical assay (Furet et al. 2013) | PMC6236629 |
| PIK3CB | 1200 nM | Biochemical assay (Furet et al. 2013) | PMC6236629 |
| mTOR | 10 μM | Biochemical assay | PMC5668434 |
| PI 4-kinase b | 0.5 mM | -- | PMC7550850 |
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Alpelisib (BYL719)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- Alpelisib (BYL719) Mechanism of Action: PI3Kα Inhibition in Breast Cancer Cell Research
- Alpelisib (BYL719) Clinical Trials
- Alpelisib (BYL719) Working Concentration | Cell Culture | Treatment
- Alpelisib (BYL719) Solubility in DMSO
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- Alpelisib (BYL719) Combination Database
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- Alpelisib (BYL719) Chemical Structure (2D and 3D)
- Alpelisib (BYL719) IC50 for Cell-based and Cell-free Assays
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- Alpelisib (BYL719) SDS｜MSDS