CAS No. 850649-61-5
Batch:
Purity:99.93
Chemical Structure
Check the
Alogliptin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 850649-61-5 | |
|---|---|---|
| Molecular Formula |
C18H21N5O2 |
|
| Molecular Weight (MW) | 339.39 | |
| SMILES | CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N |
Alogliptin is a potent and selective dipeptidyl peptidase IV (DPP-4) inhibitor, exhibiting greater than 10,000-fold selectivity over related serine proteases DPP-8 and DPP-9. Inhibition of DPP-4 blocks the cleavage and inactivation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This activity preserves active incretin levels to enhance glucose-dependent insulin secretion and improve glycemic control in cellular and preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(197.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 67 mg/mL |
| Water | 18 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.