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Alisertib (MLN8237) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Alisertib (MLN8237)
  • Catalog Number: S1133
  • CAS Number: 1028486-01-2
  • IUPAC Name: Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

The substance is not classified as hazardous according to the Globally Harmonized System (GHS).

  • GHS Label Elements: None
  • Hazard Pictograms: None
  • Signal Word: None
  • Hazard Statements: None
  • NFPA Ratings (Scale 0-4): Health = 0, Fire = 0, Reactivity = 0.
  • HMIS Ratings (Scale 0-4): Health = 0, Fire = 0, Physical Hazard = 0.
  • Other Hazards: The results of PBT and vPvB assessment indicate these are not applicable. There are no known adverse physical or health effects under the Hazard Communications Standard.

3. Composition/information on ingredients

  • Chemical Characterization: Substances
  • CAS No. Description: 1028486-01-2
  • Name: Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-

4. First-aid measures

  • General Information: No special measures required.
  • After Inhalation: Supply fresh air; consult a doctor in case of complaints.
  • After Skin Contact: Generally, the product does not irritate the skin.
  • After Eye Contact: Rinse the opened eye for several minutes under running water.
  • After Swallowing: If symptoms persist, consult a doctor.
  • Most Important Symptoms and Effects: No further relevant information available.
  • Indication of Immediate Medical Attention: No further relevant information available.

5. Fire-fighting measures

  • Extinguishing Media: Use fire-extinguishing measures that suit the environment. A solid water stream may be inefficient.
  • Special Hazards: No further relevant information available.
  • Advice for Firefighters: No special protective equipment measures required.

6. Accidental release measures

  • Personal Precautions: Not required.
  • Environmental Precautions: Do not allow to enter sewers, surface water, or ground water.
  • Methods for Containment and Cleaning Up: Pick up mechanically.
  • Reference to Other Sections: See Section 7 for safe handling, Section 8 for personal protection equipment, and Section 13 for disposal information.
  • Protective Action Criteria (PAC): The substance is not listed for PAC-1, PAC-2, or PAC-3.

7. Handling and storage

  • Precautions for Safe Handling: No special measures required.
  • Information About Protection Against Explosions and Fires: No special measures required.
  • Conditions for Safe Storage: Store in accordance with the information listed on the product insert.
  • Requirements for Storerooms and Receptacles: No special requirements.
  • Information About Storage in One Common Storage Facility: Not required.
  • Further Information: None.

8. Exposure controls/personal protection

  • Control Parameters: No components with limit values require monitoring at the workplace.
  • Engineering Controls: No further data; see Section 7.
  • Personal Protective Equipment:
    • General Hygiene: Follow usual precautionary measures for handling chemicals.
    • Breathing Equipment: Not required.
    • Protection of Hands: Use impermeable and resistant gloves. Due to missing tests, no specific glove material recommendation can be provided. Selection should consider penetration times, rates of diffusion, and degradation.
    • Eye Protection: Not required.

9. Physical and chemical properties

  • Physical State: powder
  • Appearance (Form): powder
  • Color: Not determined.
  • Odor: Characteristic.
  • Structural Formula: C27H20ClFN4O4
  • Molecular Weight: 518.9 g/mol
  • Melting Point/Melting Range: Undetermined.
  • Boiling Point/Boiling Range: Undetermined.
  • Flammability: Product is not flammable.
  • Explosion Limits: Lower and Upper not determined.
  • Flash Point: Not applicable.
  • Decomposition Temperature: Not determined.
  • pH-value: Not applicable.
  • Viscosity (Kinematic/Dynamic): Not applicable.
  • Solubility: DMF: 2 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 1 mg/mL.
  • Water Solubility: Not determined.
  • Partition Coefficient (n-octanol/water): Not determined.
  • Vapor Pressure: Not applicable.
  • Density/Relative Density: Not determined.
  • Vapor Density: Not applicable.
  • Particle Characteristics: Not determined.
  • Ignition Temperature: Not determined.
  • Danger of Explosion: Product does not present an explosion hazard.

10. Stability and reactivity

  • Reactivity: No further relevant information available.
  • Chemical Stability: Stable under recommended storage conditions. No decomposition if used according to specifications.
  • Possibility of Hazardous Reactions: No dangerous reactions known.
  • Conditions to Avoid: No further relevant information available.
  • Incompatible Materials: No further relevant information available.
  • Hazardous Decomposition Products: Carbon oxides, hydrogen chloride, hydrogen fluoride, nitrogen oxides.

11. Toxicological information

  • Acute Toxicity: No specific data provided.
  • Primary Irritant Effect:
    • Skin: No irritant effect.
    • Eye: No irritating effect.
  • Sensitization: No sensitizing effects known.
  • Additional Toxicological Information: When used and handled according to specifications, the product does not have any harmful effects according to experience and provided information. The substance is not subject to classification.
  • Carcinogenic Categories:
    • IARC: Substance is not listed.
    • NTP: Substance is not listed.
    • OSHA-Ca: Substance is not listed.

12. Ecological information

  • Toxicity: No further relevant information available regarding aquatic toxicity.
  • Persistence and Degradability: No further relevant information available.
  • Bioaccumulative Potential: No further relevant information available.
  • Mobility in Soil: No further relevant information available.
  • PBT and vPvB Assessment: Not applicable.
  • General Notes: Water hazard class 1 (Self-assessment): slightly hazardous for water. Do not allow undiluted product or large quantities to reach ground water, water courses, or sewage systems.

13. Disposal considerations

  • Waste Treatment Methods: Smaller quantities can be disposed of with household waste.
  • Uncleaned Packagings: Disposal must be made according to official regulations.

14. Transport information

  • UN-Number (DOT, IMDG, IATA): Not regulated.
  • UN Proper Shipping Name (DOT, IMDG, IATA): Not regulated.
  • Transport Hazard Class(es) (DOT, ADN, IMDG, IATA): Not regulated.
  • Packing Group (DOT, IMDG, IATA): Not regulated.
  • Environmental Hazards: Not applicable.
  • Special Precautions for User: Not applicable.
  • Transport in Bulk (MARPOL73/78 and IBC Code): Not applicable.
  • UN "Model Regulation": Not regulated.

15. Regulatory information

· Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
· Sara
· Section 355 (extremely hazardous substances):Substance is not listed.
· Section 313 (Specific toxic chemical listings):Substance is not listed.
· TSCA (Toxic Substances Control Act):Substance is not listed.
· Hazardous Air PollutantsSubstance is not listed.
· Chemicals known to cause cancer:Substance is not listed.
· Chemicals known to cause reproductive toxicity for females:Substance is not listed.
· Chemicals known to cause reproductive toxicity for males:Substance is not listed.
· Chemicals known to cause developmental toxicity:Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency)Substance is not listed.
· TLV (Threshold Limit Value)Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)Substance is not listed.
· Chemical safety assessment:A Chemical Safety Assessment has not been carried out.

16. OTHER INFORMATION

Revision Date: 2026/06/30
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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